Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
142 Cards in this Set
- Front
- Back
|
Retroperitoneal mass
|
Malignant fibrous histiocytoma
|
|
|
MC tumor postirridation
|
Malignant fibrous histiocytoma
|
|
|
Aponeurosis of ant abdominal wall
|
Desmoid tumor (deep seated fibromatosis)
|
|
|
Rhabdomyosarcomas occur in?
|
Children
|
|
|
Tumor of uterus or GI tract?
|
Leiomyosarcoma
|
|
|
needle shape crystals + negative bifiringence + warm, painful joint
|
Gout
|
|
|
Chemo drugs precipitate?
|
Secondary gout
|
|
|
Osteoclasts in fracture do what?
|
Accelerated resorption because of blast stimulation
|
|
|
Sclerotic, thick bone + HIGH ALP
|
Paget
|
|
|
Two phases of Paget's
|
Lytic; Burnt out phase
|
|
|
Vitamin D deficiency (severe)
|
Osteomalacia
|
|
|
Primary hyperparathyroidism causes?
|
Osteitis fibrosa cystica
|
|
|
Tumor projection capped by cartilage
|
Osteochondroma
|
|
|
symmetric arthritis + hands/feet + swollen,warm joints + swan neck + ulnar deviation
|
RA
|
|
|
Chronic arthritis + cartilage destruction + large joints
|
Lyme
|
|
|
Calcium pyrophosphate crystal deposition
|
Pseudogout
|
|
|
Larger hat + joint pain + narrow joint spaces + sclerosis + mosaic pattern
|
Pagets
|
|
|
Pagets increased risk for?
|
Osteosarcoma
|
|
|
Young age + focal developmental defect of bone
|
Fibrous dysplasia
|
|
|
Mass in lateral neck in kid + no pain
|
Rhabdomyosarcoma
|
|
|
Vimentin marker?
|
Rhabdomyosarcoma
|
|
|
Solid soft tissue mass + trauma
|
Nodular fasciitis\
|
|
|
Location/ age of nodular faciitis?
|
Young adults, trunk and UE's
|
|
|
Malignant fibrous histiocytoma found in?
|
Older adults
|
|
|
Contusion leads to?
|
Abscess formation
|
|
|
Deforming lesion of fascial planes + long time period
|
Superficial fibromatosis
|
|
|
Common benign soft-tissue tumor
|
Lipoma
|
|
|
Urethritis + knee pain + warm + diplococci in aspirate
|
Gonorrhea (acute suppurative arthrits)
|
|
|
Mimiks RA?
|
Lyme
|
|
|
Chancre + arthrits years later
|
Syphillis
|
|
|
MCC of osteomylitis
|
Aureus
|
|
|
Cause of osteomyelitis in children
|
H. Influenzae (gram neg rod)
|
|
|
Dexa -2.5 + femoral neck fracture
|
Osteoporosis
|
|
|
Decoy receptor for RANK?
|
Osteoprotegrin (OPG)
|
|
|
Estrogen deficiency causes what?
|
Increased IL-1, IL-6, and TNFa
|
|
|
Alderonate
|
Reduces bone resorption
|
|
|
Pain in thigh + soft tissue mass + adult male
|
Liposarcoma
|
|
|
FGF3 mutations
|
Dwarfism syndromes
|
|
|
Age of osteosarcoma
|
<20yrs males
|
|
|
Location of origin of osteosarcoma?
|
Metaphysis
|
|
|
Reactive fibroblastic lesion of young adults
|
Nodular fasciitis\
|
|
|
Tumor of head, neck, GU tract, retoroperitoneum in children
|
Rhabdomyosarcoma
|
|
|
Small, circumscribed lesions on skin in extremities + adults
|
Hemangiomas
|
|
|
man + pain in knee + mass superior & inferior to patella + biphasic spindle cells + epithelial glands + X;18 translocation
|
Synovial sarcoma
|
|
|
Origin of synovial sarcoma
|
Mesenchymal cells
|
|
|
Fibromatosis of fibroblast + collagen
|
Desmoid tumor (deep seated fibromatosis)
|
|
|
ONLY EPIPHSYEAL TUMOR
|
Giant cell tumor
|
|
|
R femoral intertronchanteric fracture
|
Osteoporosis in postmenopausal woman
|
|
|
MC form of monoclonal gammopathy
|
Multiple Myeloma
|
|
|
Lytic lesions in vertebrae that cause compression fractuers
|
Multiple Myeloma
|
|
|
man + pain in knee/back/5th finger/neck + stiffness in AM + pain worse at END of day
|
Osteoarthritis
|
|
|
Shigella + gastroenteritis + low back pain + red eye/blurred vision
|
Enteropathic arthritis
|
|
|
HLA-B27
|
Anky; Reiter; Psoriatic; enteropathic
|
|
|
Reiter syndrome caused by?
|
Chlamydia
|
|
|
draning sinus tract after fracture
|
Chronic osteomyelitis
|
|
|
Dead piece of bone
|
Sequestrum
|
|
|
Shell of reactive new bone
|
Involcrum
|
|
|
MC lesion to develop in a sinus tract from osteomyelitis
|
Squamous cell carcinoma
|
|
|
Nidus + surrounding sclerosis
|
Osteoid Osteoma
|
|
|
upper femoral mass + older male + metaphyseal origin
|
Chondrosarcoma
|
|
|
Gray-blue glistening mass in medullary cavity
|
Chondrosarcoma
|
|
|
Location of most chondrosarcomas
|
Central portions of skeleton
|
|
|
Derivation of osteosarcoma
|
Osteoblasts
|
|
|
Large, red-brown cystic tumors + 3-5th decades
|
Giant cell tumor
|
|
|
Derivation of Giant Cell Tumor
|
Osteoclasts
|
|
|
Tumor of primitive neuroectodermal cells
|
Location
|
|
|
Multiple dark red, round, lytic lesions
|
Multiple Myeloma
|
|
|
Small, round blue cells
|
Ewing sarcoma
|
|
|
Developmental arrest of bone + irregular woven bone spicules + fibroblastic stroma
|
Fibrous dysplasia
|
|
|
young male + knee pain + metaphysea origin + elevated periosteum + spindle cells forming osteoid matrix
|
Osteosarcoma
|
|
|
pain below patella + cystic area at tibial diaphysis + inc osteoblasts
|
PTH adenoma
|
|
|
Brown tumor of bone
|
PTH adenoma
|
|
|
PTH adenoma vs giant cell
|
PTH = fibroblasts; Giant cell = epiphysis + plump stromal cells
|
|
|
male child + hip pain + swelling + osteolysis + cortical erosion + metaphysis + adjacent soft tussue swelling + abscess
|
Pyogenic osteomyelitis = staph
|
|
|
Neonatal osteomyelitis
|
GBS; H influenzae
|
|
|
Sickle cell osteomyelitis
|
Salmonella
|
|
|
Sexually active + osteomyelitis
|
Gonorrhea
|
|
|
female + contracture of 3rd digit + firm, hard area under palm
|
Dupuytren (superficial fibromatosis)
|
|
|
RA is a?
|
Synovitis
|
|
|
ASA relieves pain + young girl + knee pain at night + rim of bony sclerosis at proximal tibia + cortex
|
Osteoid osteoma
|
|
|
ASA does not releive pain in?
|
Osteoblastoma (>2cm)
|
|
|
young male + knee pain + broad-based excrescense from metaphyseal region
|
Osteochondroma
|
|
|
teen male + mass in diaphyseal region + extends to soft tissue + reactive bone cover + close packed primitive cells with scant cytoplasm + 11;22 translocation
|
Ewing sarcoma
|
|
|
Subcutaneous RA nodules found over?
|
Extensor surfaces
|
|
|
RA treatment?
|
Adalimumab
|
|
|
Gummatous necrosis in joints
|
Syphillis
|
|
|
Benign tumor of hyaline cartilage in medullary space + young males
|
Enchondroma
|
|
|
Location of Ewing?
|
Diaphysis
|
|
|
Mimiks osteomyelitis
|
Ewing sarcoma
|
|
|
Soap bubble X-ray
|
Giant cell
|
|
|
Exostosis
|
Osteochondroma
|
|
|
MC malignant bone tumors in kids
|
Osteosarcoma & Ewing
|
|
|
PNET related to
|
Ewing sarcoma
|
|
|
MC bone tumor in adults
|
Metastatic carcinoma
|
|
|
EWS-FLI1 fusion gene
|
Ewing sarcoma
|
|
|
Focal lytic lesion + plasma cells
|
Plasmacytoma
|
|
|
Associated with alcohol
|
Gout
|
|
|
Chalky white deposits beneath ulcerated skin
|
Tophi
|
|
|
Mechanism of gout
|
Neutrophils phagocytize urate crystals
|
|
|
Hypercholesterolemia causes?
|
Xanthomas in tendons
|
|
|
Granulomatous inflammation + arthritis + skin lesions
|
TB
|
|
|
Best way to reduce fractures after menopause?
|
Excersize regimen
|
|
|
Pathological fracture + femoral diaphysis + central lucency + thin sclerotic rim + intramedullary + trabeculae of woven bone in fiborblastic proliferaiton
|
Single focus of fibrous dysplasia
|
|
|
Arthritis + bony erosion + lymphoplasmacytic infiltrate + arteritis w endothelial proliferation
|
Lyme (stage 3)
|
|
|
sliver skin lesions + arthritis
|
Psoriasis
|
|
|
Cause of psoriatic arthritis?
|
Epidermal hyperkeratosis, parakeratosis, elongation of rete ridges, microabscesses
|
|
|
Soft tissue mass with yellow cut surface
|
Lipoma
|
|
|
Sex in giant cell?
|
Female
|
|
|
Osteoblastoma involves?
|
Spine
|
|
|
Small tumors of small bones of hands and feet?
|
Endochondromas
|
|
|
Compression fractures of spine + abscess of muscle
|
TB
|
|
|
Rash across nose & hands + arthritis + inc lymphs
|
Juvenile Rheumatoid Arthritis
|
|
|
Charcot joint
|
Syphillis
|
|
|
inc neutrophils + arthritis + swollen + CHF/DBM/Hepatic cirrhosis
|
Hemachromatosis causing a pseudogout
|
|
|
Tender/swollen DIP joints
|
Osteoarthritis
|
|
|
soft tissue mass that calcifies into bone (within muscle)
|
Myositis ossificans
|
|
|
Stillborn + osteopenia + fractures
|
Osteogeneisis Imperfecta
|
|
|
What variant of OI is lethal
|
Type II
|
|
|
ANA + dsDNA positive + proliferative glomerulonephirtis + steorid therapy
|
Patient has SLE steroids can cause avascular necrosis
|
|
|
Radiolucency + density of femoral head with flattening of bone
|
Avascular necrosis
|
|
|
Avascular necrosis associations
|
Steroids, sickle cell, fracure, barotrauma, hypercoaguable states, hyperlipidemia
|
|
|
Bump on dorsum of wrist + pain + mucoid fluid
|
Ganglion cyst
|
|
|
Diffuse form of giant-cell tumor of tendon sheath
|
Villonodular synovitis
|
|
|
BL hearing loss + yellow-brown teeth + bell shaped teeth + steel-gray (blue) sclera + fractures
|
Osteogenesis imperfecta type I
|
|
|
Short + bow-legged child
|
Acondroplasia
|
|
|
Homozygous form of acrondroplasia?
|
Thanatrophoric dysplasia (lethal dwarfism)
|
|
|
Growth retardation + mental retardation + hepatosplenomegaly + joint stiffness
|
Mucopolysaccharidosis I (Hurler syndrome)
|
|
|
fractures + hepatosplenomegaly + CN palsies + pancytopenia + sclerotic bones
|
Osteopetrosis (Albers-Schonberg disease)
|
|
|
MC sites for firbrous dysplasia?
|
Ribs, femur, tibia, mandible, calvaria
|
|
|
Garner polyposis associated with?
|
Osteoma
|
|
|
Fibrious dysplasia + cafe-au-lait spots + endocrinopathies
|
McCune-Albright syndrome
|
|
|
Locations for polyostotic fibrous dysplasias?
|
Craniofacial, pelvic, shoulder girdle
|
|
|
McCune-Albright syndrome occurs in?
|
young girls
|
|
|
Defect in collagen 1 formation
|
Osteogenesis imperfecta
|
|
|
EXT mutations seen in?
|
Osteochondromas
|
|
|
HGPRT in?
|
X-linked Lesch-Nyhan syndrome
|
|
|
RB mutation
|
Osteosarcoma
|
|
|
No vitamin D
|
Rickets
|
|
|
No vitamin C
|
Scurvy
|
|
|
Mutation in carbonic anyhydrase?
|
Osteopetrosis (Albers-Schonberg disease)
|
|
|
Why are people deaf in osteopetrosis?
|
Ossicles deformed
|
|
|
Erlenmeyer flask deformitiy - bone in bone
|
Osteopetrosis (Albers-Schonberg disease)
|
