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8 Cards in this Set
- Front
- Back
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Histamine Receptors |
4 Subtypes, All GPCR's. Utilize cAMP or Ca++ second messengers. H1-endo H2-gastric H3-neurons H4-WBC's. |
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Nitric Oxide |
Paracrine molecule, made by NOS from arginine. Binds to heme in Guanylyl Cyclase, ^cGMP, activates cGMP dependent kinases that phosphorylate proteins for smooth muscle relaxation. Drugs for ED stimulate guanylyl cyclase, inhibit phosphodiesterase that breaks down cGMP. NO produced by macrophages contributes to killing of microbes via reaction w/ O2 producing radicals. |
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eNOS |
Constitutively produced by endothelial cells and some neurons |
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nNOS |
Constitutively produced by autonomic nerves, skeletal muscle, and epithelial cells. Associated with Dystrophin in skeletal muscle, lost in muscular dystrophy. |
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iNOS |
Produced in times of stress |
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Carbon Monoxide |
Mediates vessel dilation, produced during breakdown of heme. Reacts only with Fe containing compounds, stimulates Guanylyl cyclase to increase cGMP but with lower potency than NO. |
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Eicosanoids |
Family of PUFA's that includes PG's PGI's TX's LT's LX's. Short 1/2life limited to autocrine and paracrine signaling. All made from arachidonic acid. Exert affects via GPCR's |
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NT Receptors |
2 Types: Ion channels and GPCR's. Fast synaptic transmission via ion channels. Slow transmission via GPCR's. Ach and Glutamine excitatory, cation channel, depolarize. GABA and Glycine, inhibitory, anion channels, hyperpolarize. |
