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4 Cards in this Set
- Front
- Back
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How does a mutation in Factor V (Factor V Leiden) cause thrombophilia.
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mutation in Factor V makes it resistant to breakdown by protein C (increased coagulation)
also decreases activity of protein C in breaking down other parts of the clotting cascade (decreased anticoagulation) |
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What is the risk of VTE in pregancy with the following mutations:
Factor V Homozygote Factor V Heterozygote Prothrombin gene homozygote Prothrombin gene heterozygote Factor V + Prothrombin gene double heterozygote ATIII Prot C Prot S |
Factor V hetero: <0.3%
Factor V homo 1.5% PT gene mut hetero <0.5% PT gene homo 2.8% Factor V + PT hetero 4.7% AT III 3-7% Prot C 0.1-0.8% Prot S 0.1% |
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Which thrombophilias are most common?
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Factor V and PT gene mutation
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Most common cause of VTE in pregnancy?
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Factor V Leiden (40% VTE) hetero
PT Gene mutation (17%) Prot C (14%) Prot S AT III (1%) |
