• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/64

Click to flip

64 Cards in this Set

  • Front
  • Back
Cytokines released by T-cells leading to further joint inflammation in RA
TNF, interleukins
Disadvantage of using NSAIDs
Don't alter the disease course
Flector Patch
Diclofenac
RA
q12h
Pennsaid
Diclofenac solution
For knees only
Lidone (XL)
Etodolac
600mg-1200mg/d in bid or qid
Indocin (SR)
Indomethacin
PO IV Supp
100-200mg/d
Can cause more headaches
Felafen
Nabumetone
NSAID
Tolectin
Tolmetin
NSAID
Clinoril
Sulindac
NSAID
Ibuprofen
Max 3200mg/d in tid-qid
Orudis
Ketoprofen
Max 300mg/d in tid-qid
Oruvail
Ketoprofen SR
100-200mg/d qd
Naprosyn
Naproxen
500-1500mg/d in bid tid
Feldene
Piroxicam
10-20mg/d qd bid
Celebrex
Celecoxib
200-400mg/d qd bid
Mobic
Meloxicam
If pt is on high dose of NSAIDs think about giving this medication
PPI, H2RA, misoprostol
NSAIDS with high ulcer risk
Piroxicam
NSAID ADR
Ulcers
Hepatic failure
Renal blood flow decrease
What allergies must Celebrex be avoided in?
Sulfa
Advantages of using DMARD
Preserve joint integrity and function
Monotherapy for all categories of RA
Methotrexate, Leflunomide
Plaquenil
Hydroxycloroquine
Decreases interleukin-1 from monocytes
200mg bid
Myochrisine
Gold sodium thimalate
Minocin
Minocycline
MTX sig DDI
Bactrim (can cause added hematologic abnormalities)
NSAID and ASA can increase concentration
Folic Acid recommended doses for pt on MTX
max 3mg/day
All pts on DMARDs should recieve ___ prior to DMARD initiation
vaccines
MTX dose
7.5-25.0mg po qwk
Avara
Pregnancy category X
If wish to get pregnany must follow drug elmination protocol
Avara ADR
Diarrhea, LFT, alopecia, hypertension and rash.
Avara DDI
Increased liver tox when used in conjunction with MTX
Avara elimination protocol
8g of Questran tid for 11 days;
plasma levels of M1 > 0.02mg/L verified on 2 occasion 2 weeks apart.
Avara dosing
100mg qd x3days, 20mg qday
Cuprimine
D-penicillamine
Thrombocytopenia
Proteinuria
Rash
Stomatitis
Cuprimine administration
TAKE ON EMPTY STOMACH
Gold ADR
RASH
sun sensitivity
Protein/hema-uria
Leukopenia
anti-TNF therapy for RA
Enbrel
Remicade
Adalimumab
Anti-TNF ADR
INFECTIONS (no live vaccines)
Rash
Nausea
Cough
Enbrel
Kineret
100mg sc qd
Orencia
CI with other DMARDs
CI Live vaccines
Rituxan
Last line therapy
Pre-medicate with glucocorticoid
1000mg q 2wk
Imuran
Azothiaprine
50-150mg/d po qd bid
CBC, creatinine, lft
DDI with allopurinol
Hypertension
Nephrotoxicity
Glucose intolerance
Hepatoxicity
Hypertension
Nephrotoxicity
Glucose intolerance
Hepatoxicity
Pt on chronic glucocorticoid should recieve
1500mg elemental calcium and 400-800IU of vitamin D/day
Lifestyle modification in RA
increase protein intake
DOA for OA
APAP
Ultram (ER)
400mg/day
Don't take with MAOI
Constipation/ n/v, sz, and withdrawal sx
Chondroitin and Glucosamine DDI
Warfain
May increase risk of bleeding
Colchicine for RA dose
1.2mg po then 0.6mg 1hr later. Max 1.8mg over 1 hr.
IV PO

Dose renally

Most effective when given within 12-36 hours of attack
Colchicine indication
chronic suppressive therapy for gout
Colchicine ADR
NVD, bloating.
Bone marrow suppresion
Extravasation

Don't give in PUD
Benemid
Probenecid
Blocks uric acid uptake in proximal tubule
Benemid counseling
Drink plenty of water to prevent stones

Don't use in gouty attack b/c it may exacerbate it.
Benemid DDI
NTF decreased efficacy
Penicillin increased efficacy
May increase [sulfonylurea]
During gouty attack what meds to give and which to avoid
give: NSAIDs, Colchicine
avoid: probenecid
Benemid dose
250-500 mg po bid
Zyloprim
Allopurinol
300mg po qd
Rash
Uloric
Febuxostat (Zyloprim like agent)
Elitek
Rasburicase (don't use in pt with G6PD)
antiphosphoslid antibody (from SLE) increases the risk of ___
Stroke
Treatment of SLE
Hydroxychloroquine
Glucocorticoid
cyclophosphamide
NSAIDs