Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
226 Cards in this Set
- Front
- Back
- 3rd side (hint)
What do most OTC analgesics act on?
|
Cox Enzymes which are necessary for prostaglandin formation
|
|
|
Does Cox 1 act peripherally or centrally?
|
peripherally
|
|
|
when Cox 1 is inhibited, what effects are caused?
|
gastric ulceration
acute renal failure bleeding tendencies relaxes uterine muscles |
|
|
What are the good effects of Cox 1?
|
gastric protection
maintains renal bl. flow causes clotting promotes uterine contractions |
|
|
Does Cox 2 act peripherally or centrally?
|
both
peripheral act: causes inflammation central: causes pain & fever |
|
|
Inhibition of Cox 2 causes?
|
reduced inflammation, fever and pain
|
|
|
What are non-narcotic analgestics?
|
Salicylates-Aspirin
Para Aminophenol Derivatives: Tylenol/acetaminophen NSAIDs- AIMs- motrin,ibuprophen, aleve Urinary tract analgesic: Pyridium/phenazopyridine |
|
|
Sayicylates/ASA acts by?
Most common adverse effect? |
inhibiting Cox 1 & 2
GI upset, PUD. renal failure |
|
|
Renal failure w/ ASA high doses may occur in pts with?
|
Rheumatoid arthritis, chronic headaches
|
|
|
What are the signs of ASA toxicity?
|
dizziness, tinnitus, N&V
|
|
|
Why are ASAs contraindicated for children under 18?
|
Reye's syndrome
|
|
|
How does para aminophenals-Tylenol/acetaminophens work?
|
inhibit Cox enzymes centrally not peripherally
|
|
|
What is the max dose of Tylenol?
|
4 gm/day
|
|
|
Large doses of Tylenol may cause?
|
Hepatoxicity
|
|
|
What is the overdose antidote for Tylenol?
|
Mucomyst
|
|
|
What are the catagories of NSAIDS?
|
non-selective
selective |
|
|
What are the non-selective NSAID?
|
AIMS - Aleve, ibuprophen, Motrin
|
|
|
What are the selective NSAID?
|
Celebrex/celecoxib
|
|
|
What are the adverse effects of NSAIDs?
|
GI/PUD
|
|
|
Which Cox does Celebrex block and which properties does it have?
|
blocks 2
pain & anti-inflammatory |
|
|
What are NSAIDs useful in treating?
|
Rheumatoid arthritis
Menstrual cramps Post op-pain |
|
|
Drug of choice for pt with renal failure?
alcoholic pt? less effective w/inflammation? |
tylenol
(if no liver problems) |
|
|
Most effective in treating pain in a chronic inflammatory condition?
|
NSAIDs - less GI impact
|
|
|
Urinary tract analgesics like Pyridium are often combined with?
|
Bactrim- antiseptic
so sulfa drug and pain drug together-turns urine orange-red |
|
|
What are common Opioids?
|
Morphine
Stadol Valium-benzodiazepine barbituates-Luminal Amphetamines-Dexadrine Demerol |
|
|
How do Opioids work?
|
bind to opiate receptors in brain and spinal cord
alters pain perceptions |
|
|
Bad side effect of Opioids?
|
decreased GI motility-constipation, respiratory depression (<12=hold drug)
|
|
|
Overdose of Opioids treated with?
|
Narcan
|
|
|
Narcan is contraindicated with?
|
chemically dependent pts, will cause withdrawal
|
|
|
What nursing assessments/interventions should be noted for Opioids?
|
respirations
constipation flatulance pain scale |
|
|
Which is a mixed agonist-antagonist Opioid?
|
Stadal
|
|
|
How does Stadal work?
|
decreases pain w/o respiratory depression and GI problems, but not as effective to treat pain about the same as tylenol/NSAIDs
|
|
|
How does Valium work?
|
increases neurotransmitter levels, reduces anxiety-anti-anxiety drug, pain drug, muscle relaxant
|
|
|
What is another anti-anxiety drug?
contraindicated with Another? |
Dalmine
elderly-long half life Luminal/pentobarbital |
|
|
Most common side effect w/ anti-anxiety is?
|
sedation
and d/c slowly to prevent withdrawal |
|
|
Most common Barbituate?
|
Luminal/pentobarbital
|
|
|
How is Luminal used?
|
treats anxiety, seizures, reduces pain and is a sedative
|
|
|
The drug effects of Luminal are?
|
suppresses REM sleep
raises the seizure threshold |
|
|
What are nervous system stimulants?
|
Amphetamines-
Dexadrine/dextroamphetamine |
|
|
How does Dexadrine work?
|
increases norepinerphrine, dopamine and serotonin
|
|
|
Dexadrine causes?
|
amp.-euphoria, good side effects
it is what makes them be abused causes: hyperactivity |
|
|
What is Dexadrine/dextroamphetamine used to treat?
How do you know there is an overdose? |
narcolepsy, ADHD & obesity
causes convulsions/seizures, increases HR |
|
|
Do not give amphetamines with?
What happens when you give amps with MAOIs? |
MAO inhibitors-
hypertensive crisis |
|
|
Since amps increase nonepinphine which pts should not get this drug?
|
Heart disease, HTN, glaucoma pts
do not give with MAOI's "blocks the blocker"-doubles the epinephrine |
|
|
What are some antidepressants?
|
Tricyclic/Elavil
SSRI's-Prozac MAOIs St.Johns Wort |
|
|
What is a typical anti-depressant?
What is a non-typical/atypical anti-depressant? |
Tricyclic agents-Elavil-treats chronic pain & depression
Wellbutron- MAOI's-treat unusual problems such as bulimia |
|
|
Elavil is used to treat what?
|
depression & chronic pain
|
|
|
What are the side effects of Elavil?
|
sedation, orthostatic hypotension, wgt gain
anticholinergic effects |
|
|
Most serious side effect of Elavil?
|
cardiac toxicity/arrythmias
|
|
|
Elavil is contraindicated in pts that?
|
are suicidal-lethal with 5-10 day supply
|
|
|
Elavil is contraindicated with what drugs?
hint |
MAOIs, sympathomimetics, anticholinergics
|
s.e. of Elavil/Tricyclic is anticholinergic as is MAOI and sympathomimetics so would be senergenic
|
|
SSRI's such as Prozac have what side effects?
|
sexual dysfunction, wgt gain, & Serotonin syndrome
|
|
|
Which drugs are associated with Serotonin syndrome?
|
Prozac (SSRI) & MAOI- cannot use together-all anti-depressants can cause-all Opioids-all CNS stimulates (amps)-lithium-illegal drugs
|
|
|
MAO inhibitors like Wellbutrin are used to treat?
|
bulimia, panic attacks, OC disorders
|
|
|
Main side effects of MAOI's?
|
CNS stimulation, hypotension
hypertensive crisis if eat foods with tyramine many drug interactions especially with any serotonions- will cause Serotonin syndrome |
|
|
What is released if you eat foods with tyramine?
|
nonepinephrine
|
|
|
What is main side effect of St. John's Wort?
|
photosensitivity
|
|
|
What is the major mood stabilizer?
|
Lithium/Eskalith
|
|
|
Lithium is what type of mineral?
|
salt- can cause fluctuations in renal Na regulation
|
|
|
Because of renal Na fluctuations in the taking of Lithium, what labs should be done?
|
blood serum levels
|
|
|
Why is written permission required for the taking of Lithium?
|
there is a high risk for toxicity
|
|
|
Major side effects of Lithium that affect 70% of pts?
|
tremors, wgt gain, fatigue, edema (w/all its problems)
many drug-drug interactions |
|
|
What do anti-psychotics treat?
|
schizophrenia
|
|
|
What are the antipsychotics?
|
typical- Thorazine
Atypical- Resperdal |
|
|
What are the positive effects of schizophrenia?
What drug treats these? |
agitation, delusions, hallucinations, paranoia
Thorazine |
|
|
What are the negative effects of schizophrenia?
What drug treats these? |
blunted affect, poor hygiene, poverty of speech, social withdrawal
Resperdal |
|
|
How do antipsychotics work?
|
decrease amts of neurotransmitters, dopamine & serotonin in CNS
could take w/antidepressants with caution by assessing for serotonin symdrome, CNS stimulators |
|
|
Extrapyramidal symptoms are caused by what group of drugs, which drug in particular?
|
Anti-psychotics
Thorazine Haldol |
|
|
What are the symptoms of Extrapyramidal symptoms (EPS)
|
early symptoms:
dystonia akathisia parkinsonism Late symptoms: Tardive dyskinesia |
|
|
What is dystonia? and which group of drugs cause this?
hint |
spasms, prolonged contractions of muscle groups
When give antipsychotics will cause pts to pull to one side antipsychotics |
can be treated w/Sinemet or Artane (both anti-parkinson)
|
|
What is akathisia? what group of drugs cause this?
|
continuous restlessness, inability to sit still
antipsychotics- Thorazine, Haldol |
|
|
What is tardive dyskinesia?
|
a late symptom of EPS- a side effect of anti-psychotic drugs like Haldol or Thorazine-lip smacking -usually irreversible "fly catching"
|
|
|
The most serious of all side effects of antipsychotics are?
|
Neuroleptic Malignant Syndrome- lead pipe, sudden high fever & changes in cognition
Dantrium used for treating |
|
|
Atypical Antipsychotic Agents are?
|
Rusperidone/Risperdal
|
|
|
What does Risperdal treat?
What are the side effects of Risperdal? |
it treats the negative symptoms of schizophrenia
orthostatic hypotension, fewer EPS symptoms |
|
|
What group does Respirdal treat well and what does it treat?
|
treats the elderly and treats agitation (the negative effects-although agitation is a postive effect?)
|
|
|
Nursing implications of anti-psychotics are:
|
READ the literature
take as prescribed refer to mental health agency monitor pt during 1st few wks report any anticholinergic effects -urinary retention etc |
|
|
Neuromusclar System drugs/skeletal muscle relaxants are which drugs?
|
Flexeril
Lioresal/baclofen |
|
|
How does Flexeril and Lioresal work?
What are the side effects? Contraindications? |
relieves acute muscle spasms, (does not treat spasticity)
& Lioresal treats spasticity drowsiness, dizziness do not use w/other CNS depressants |
|
|
What are the antiparkinson agents?
|
Anticholinergics- Artane/trihexyphenidyl
Dopaminergic agents-L-Dopa |
|
|
What do anticholinergic/antiparkinson agents do?
|
decrease acetylcholine
|
|
|
Side effects of anticholinergic/Artane are?
hint |
anticholinergic reactions
CNS depression, thick pulmonary secretions |
antiparkinson drug
|
|
What are the side effects of Dopaminergic drugs-L-Dopa?
|
NV, orthostatic hypotension
dyskinesia |
|
|
At what time of the day would you take L-Dopa?
|
unusual s.e.-gradual loss of effectiveness during day
may lose effectiveness for no reason then lose their effectiveness after 2 yrs |
|
|
What is Sinemet 25/100?
|
combination drug for antiparkinson- L-dopa and carbidopa
|
|
|
What are the anticonvulsant drugs?
|
Hydantoins & Barbituates & Tegretol
|
|
|
What does Dilantin treat?
|
anticonvulsant-prevents seizures
|
|
|
What are the side effects of Dilantin?
|
nystagmus, gingival hyperplasia
many drug-drug interactions decreases effect of contraceptives treats epilepsy |
|
|
What does Luminal/phenobarbital treat?
How does it work? |
anticonvulsive-treats seizures
raises the seizure threshold |
|
|
What are the side effects of Luminal?
|
drowsiness, dizziness
|
|
|
What does Tegretol treat?
|
seizures-treats better than other drugs but has to have labs done
|
|
|
What labs are needed when taking Tegretol?
|
CBC's need to be drawn
|
|
|
What is the problem with Tegretol?
|
causes hematologic problems
|
|
|
Anesthesia -what are some of the drugs?
|
Penothal/thiopental (barbituate-short acting)
General- Forane/isoflurane Nitrous Oxide- Injectable-ketamine/Ketalar Conscious sedation- Versed/midazolam |
|
|
How does Penothal work?
|
neuromusclar blocking agent, opioid, relieves pain
|
|
|
How does Forane work?
|
admin by inhalation
decreases laryngeal reflexes offer precise and rapid control of depth of anesthsia |
|
|
What organ excretes Forane?
|
the lungs
|
|
|
What are the s.e. of Forane?
|
hypotension, respiratory suppression, Malignant Hyperthermia (sudden & severe increase in body temp)
|
|
|
What side effects do any Opioid have?
|
respiratory distress, sedation,
|
|
|
What is the antidote for Forane?
|
Dantrium/dantrolene
Also antidote for Thorazine induced NMS |
|
|
How does Nitrous Oxide work?
|
relieves pain and numbs conciousness-begins in seconds and last 10 min
|
|
|
What is the most common injectible anesthesia?
|
ketamine/Ketalar "special K"
|
|
|
How is ketamine/Ketalar used?
|
for short term surgery
causes pain relief, sedation, immobility & AMNESIA |
|
|
What is Versed used for?
|
anesthesia drug, conscious sedation, minor surgeries and endoscopy, not analgesic so often combined with one
VERY HIGH AMNESIA RATE |
|
|
What are the side effects of Versed?
|
respiratory depression & cardiac arrest
Pt MUST BE MONITORED AT ALL TIMES |
|
|
What drug interaction does Versed have?
|
when given with opioids must decrease the dosage of the opioids in half-synergises the opioid
|
|
|
What are some adjuncts of Anesthesia?
|
often pain reliever, anticholinergic, and anti-anxiety agents given pre-op
often cholinergic agents are given post-op-Duvoid |
|
|
What are some Emetic drugs?
|
Amorphine
Syrup of Ipecac |
|
|
Why must you monitor pts on Amorphine?
|
has narcotic effect, do not want pt to throw up while passed out
|
|
|
How is amorphine given?
hint |
parenteral
|
injection or infusion
|
|
What are some nursing implications of emetic drugs?
|
do not give to pts w/decreased gag reflex-must be alert
do not give if ingested petro or caustic materials give charcoal after emetic |
|
|
What is the main Antiflatulent drug?
How does it work? |
Simethicone/Mylicon
disperses gas pockets |
|
|
What are some of the digestive agents?
|
HCI-
Pancreatic agents-Pancreatin Hepatic agents-bile salts |
|
|
How does HCI work?
How do you admin HCI? Contraindicated in? |
changes pepsinogen to pepsin
by straw PUD |
|
|
What is Pancreatin used for and how is it taken?
|
used for replacement therapy (for ex. in Cystic fibrosis) and taken with meals
|
|
|
What are the uses of bile salts and the contraindications of them?
|
stimulates prod. of bile & bile flow from liver
prevents gallstones cont>biliary obstruction |
|
|
What are the two types of antidiarrheals?
|
systemic- Paragoric/Lomotil
topical-Kaopectate |
|
|
What type of drug is Paragoric and what is its action?
When is it used? |
it is an opium derivative (creates constipation) and it decreases peristalsis
with acute non-specific diarrhea and in tube feedings |
|
|
What is Kaopectates action?
What does it treat? |
adsorbent, sooths intestine, mild action
bacterial or toxic diarrhea |
|
|
What is a side effect of Kaopectate (topical antidiarrheal)?
|
decreases the absorption of some meds.
|
|
|
What should a nurse look for when given antidiarrheals?
|
assess bowel function
Should not use for more than 48 hours |
|
|
What are the types of laxatives?
|
1.Hyperosmolar-MOM, fleets, glycerin suppository
2.fiber/bulk -Metamucil 3.Emollient/stool softener-Surfak & colase 4.Stimulants/Irritants-Dulcolax 5.Lubricant- Mineral Oil |
|
|
How do most laxatives work?
In what time period do they work? |
by causing water to be drawn into the bowel and/or by increasing peritalsis
most take 6 hrs and over po or if supp. then 30 min, bulk and stool softerners take a couple of days |
|
|
What must a pt do when taken any type of laxatives?
|
drink plenty of water-may cause hypovolemia (low bl. volume) if they do not
|
|
|
Who should use a stool softener?
|
pt that should avoid straining at stool
or with disease of the rectum or anus |
|
|
How does Dulcolax work?
|
increase peristalisis
discolors urine can cause rectal fissures |
|
|
What is the problem with Mineral Oil?
|
decrease absorption of KADE vitamins
don't use in pts with rectal surgary |
|
|
How do antihistamines cause constipation?
How do decongestants cause constipation? |
it has anticholinergic effects
sympathetic response-slows peristalsis |
|
|
What are the antiemetics?
|
Benedryl
Phenergan Emetecon Scopolamine Reglan |
|
|
What do antiemetics treat?
|
nausea and motion sickness
|
|
|
Most antiemetics have the side effects of?
|
sedation(except for Emetecon),. anticholinergic effects photosensitivety
|
|
|
How does Phenergan work?
Emetecon is usually used when? Scopolamine is used for? Reglan works by? |
central acting-blocks CNS receptors
-with anesthesia-inhibits the nausea motion sickness by patch -increasing GI motility & suppresses vomiting center |
|
|
What are some problems with Reglan?
|
monitor for respirations, moves quickly through GI tract & constricts cardiac spincture
|
|
|
What are some of the gastric secretions?
what PH should the gastric tract have? What PH should the Mucous layer have |
HCI, pepsin, intrinsic factor, gastrin
1-2 7.0 |
|
|
What are some intestional secretions?
what is the ideal PH for intestines? |
pancreatic enzymes, bile-creates alkaline
above 7.0 |
|
|
What causes PUD?
|
increased HCI production
maybe damage to mucosal layer due to ASA, NSAIDs increased nocturnal acid production |
|
|
How long does it take for the treatment of PUD to take effect?
|
4-6 wks
|
|
|
What are the types of drugs that treat PUD?
|
antacids
Histamine H2 receptor antagonists Sucralfate/Carafate Cytotec/misoprostol(NSAID induced pud) Prilosec/omeprazole(proton pump) Antibiotics |
|
|
What are the actions of antacids?
|
mixes with stomach contents to raise PH 3-3.5, alkalizes the stomach
stops esophageal ulceratins |
|
|
How should you take antacids?
|
on an empty stomach will take 1 hr, on full -3 hrs
but should take round the clock |
|
|
What are some of the side effects of antacids?
|
Diarrhea with magnesium
constipation with aluminum electrolyte imbalance |
|
|
What are some of the nursing implications of antacid dosage?
|
don't give w/ oral meds
shake chew tablets and then drink water don't give w/enteric coated tablets may speckle stools |
|
|
What are the H2 drugs?
|
Histamine receptor antagonists
Tagamet(not a good drug) Pepcid Zantac |
|
|
How does Sucralfate/Carafate work?
What is wrong with scheduling this drug? |
adheres to ulcer site-forms a protective barrier
give 30 min ac (b4 meals) and hs (b4 bedtime) |
|
|
What is the bad side effect of Cytotec/misoprostol?
|
induces abortions=PUD drug
|
|
|
What is Prilosec used for?
How does it work? |
reflux exophagitis
inhibits a step in the acid production process |
|
|
Why would antibiotics be given for treating PUD?
|
may be caused by H. pylori-
treated w/Tetracyclines |
|
|
What are corticosteroids?
|
all secretions of the adrenal glands, produced cyclically-lrg amt in morning, smlest at night
-works on negative feedback |
|
|
What are the good and bad effects of corticocorticoids?
|
may cause atrophy
adrenal crisis (gradually withdraw) inhibits inflammation-increases chances of infection causes edema (w/all effects) including HTN & lower K+ -causes Cushing symptoms GI disturbances Hyperglycemia-breaks down protein which release glucose -has a catabolic effect -CNS effects -Osteoporosis |
|
|
What are the nursing implications of steroids?
|
do not use w/pts w/PUD, HTN, infections, diabetes
do not give w/ASA or NSAIDs monitor wgt gain, lab values and many many more |
|
|
When would you use a steriod?
|
with allergies, dermatitis, rheumatic diseases
colitis, emphysema, lupus |
|
|
What is a mineralcorticoid?
|
glucocorticoid, Aldosterone
|
|
|
What is the use of Aldosterone?
what is its action? |
replacement therapy in adrenal insufficiency
on the kidney to retain Na and water, and excrete K+ |
|
|
What would be s,e. of Aldosterone?
Contradictions of Aldosterone? hint |
edema, hypertension, hypernatremia, hypokalemia
HTN & heart disease |
all steroids will have edema problems-w/edema get high sodium, low K+, hypertension, heart disease
|
|
What should be the nursing implications of
Aldosterone? hint |
encourage foods high in K+, low in Na
monitor those lab values monitor wgt |
is a steroid so edema
|
|
What is the major immunosuppressant used?
|
cyclosporine/Sandimmune
anti-rejection agent |
|
|
How is cyclosporine used?
How does it work? |
stops organ rejection sometimes with another immunosuppressant for synergistic effect-
-inhibits or modifies the immune system |
|
|
Problems with cyclosporine?
|
highly protein bound
many drug interactions ---no immunizations with any immunsuppressants |
|
|
What are some side effects of immunesuppressants like cyclosporine?
|
Nephrotoxity, infection
|
|
|
What is the nursing implications for immunesuppressants like cyclosporine?
|
Nephrotoxicity- monitor creatine & BUN levels, watch for decreased urinary output
|
|
|
What are the meds for Antigout?
|
Benemid
Zyloprim/allpurinol Colchicine |
|
|
How do all three Antigouts work?
|
Benemid-increases pee
allpurinol-inhibits enzyme in uric acid synthesis Colchicine (treatment only) stops the inflammation,decreases leucocyte movement into the tissues |
|
|
What are the side effects of Antigout meds?
|
GI upset
renal calculi |
|
|
How should Benemid be taken?
|
with meals, with plenty of fluids, with vegs but not with ASA
|
|
|
What is the last choice drug for rheumatoid arthritis?
|
gold salts- given w/NSaids
se-diarrhea, stomatitis, alopecia, monitor CBC |
|
|
What are side effects of antiinfectives?
|
Toxic effects: nephrotoxicity
hepatoxicity ototoxicity opic nerve damage |
|
|
What drug is given with Penicillin to increase the time it stays in the body?
|
Benemid, antigout med
|
|
|
What should you watch for when giving cillins?
|
they are mixed with K+ or Na so can cause renal problems when either electrolyte is higher or lower
|
|
|
What should nurses look out for when giving cillins and cefs?
|
diarrhea called pseudomembranous colitis, caused by opportunistic growth of C.difficile in in the bowel
|
|
|
What should the pt not use as a fluid to take cillins?
|
acidic fluids, destroys cillins
|
|
|
Are cillins gram negative or gram positive?
Are cefs gram - or gram +? |
gram negative
gram + |
|
|
What antiinfective must you watch out for if you are allergic to cillins?
|
cefs-cephalosporins
|
|
|
What are nursing implication for cefs?
hint |
assess for renal function, Pseud. colitis
thrombophlebitis at IV infusion site |
Cephalosporins
|
|
What are complications of Aminoglycoside/mycin dosage?
|
kidney (nephrotoxic) ears(ototoxic)
keep well hydrated follow peak & troughs** do not give more than 10 days effects last even after dose is stopped |
|
|
What is one of the most common mycins/Aminoglycoside?
|
gentomyacin-gram negative
|
|
|
What is the most common Fluoroquinolones/oxacins?
|
Cepro
-broad spectrum |
|
|
What age group is not to be given Cepro?
|
under 18-cause joint problems
|
|
|
What are side effects of Cepro?
|
photosensitivity
liver dysfunction test: ATL/AST or SGOT/SGLT |
|
|
What does Tetracyclines treat?
|
acne
PUD caused by H.pylori various fevers broad spectrum |
|
|
What is contraindicated when taking Tetracyclines?
|
do not give with milk or multi vitamins
discolors teeth under 8yrs old decreases eff. of contraceptives can cause suprainfections |
|
|
What is a very toxic anti-infective?
|
Chloramphenicol
|
|
|
What are the toxic effects of Chloramphenicol?
|
aplastic anemia
gray syndrome bone marrow depression |
|
|
What anti-infective is used for serious infections?
|
Clindamycin
|
|
|
What is a side effect of Clindamycin?
|
pseudomembranous colitis
diarrhea |
|
|
What is one of the most common anti-infectives?
|
erythromycin E-mycin
|
|
|
What does sulfonamides treat?
|
most often urinary infections
|
|
|
What anti-infective causes Stevens-Johnson syndrome?
|
sulfonamides
|
|
|
almost All anti-infectives cause?
|
photosensitivity
diarrhea (some P.colitis) must hydrate can be nephrotoxic & ototoxic |
|
|
What drug is used to treat MRSA?
|
Vancomycin
|
|
|
What is the drug resistant strain caused by misuse of Vanomycin?
|
VRE
|
|
|
What are the side effects of Vancomycin?
|
very ototoxic & nephrotoxic
RED man syndrome hypotension |
|
|
What is a urinary antiseptics?
|
nitrofurantoin/Macrodantin
|
|
|
What are side effects of Macrodantin?
hint |
turns urine brown or rust colored
|
a urinary antiseptic
|
|
What drug is Macrodantin combined with to treat urinary infection?
|
Bactrim (sulfa & antiseptic)
|
|
|
Drugs used to treat TB are?
|
INH
Rifampin Ethambutol |
|
|
What is the s.e of INH?
What is the s.e of Rifampin What is the s.e of Ethambutol? |
peripheral neuropathy(tingling)
hepatoxicity/hepatitis -GI upset & red-orange secretions -optic neuritis-cannot see red & green |
|
|
How are most anti-TB drugs used?
|
in combination with other TB drugs
|
|
|
What drug treats infuenza A?
|
amatadine/symmatrel-an antiviral agent- an immunization
|
|
|
What are the s.e. of AZT?
|
bone marrow s.e.: anemia, neutropenia
|
|
|
What antifungal treats severe infections?
|
amphortericin B/Fungizone
|
|
|
What is a bad s.e. of Fungizone?
|
very nephrotoxic so should
hydrate, check output |
|
|
With IV admin of Fungizone what should be done pre-op?
|
give tylenol, benadryl, corticosteroid or Demerol b/c IV admin causes fever & chills
|
|
|
Should Fungizone be admin. fast or slow through the IV
|
slow with large bore needle, and admin low-dose Heparin
|
|
|
What anti-fungal treats yeast infections?
|
nystatin/Mycostatin
Fungazode treats systemic infections |
|
|
Why is nystatin/Mycostatin given with antibiotics?
hint |
because yeast is an opportunistic infection
|
anti-fungal
|
|
What is an Anthelmintic agent?
|
kills worms
|
|
|
What are the s.e of Chemotherapy?
|
Neutropenia(wbc)-causes infection
Thrombocytopenia Anemia N&V Stomatitis Alopecia Reproductive effects |
|
|
What should be a normal WBC?
What is NADIR? |
5,000-10,000
on chemo if less than 3,000 red flag -lowest WBC following chemo 7-14 days following -major dose limiting factor |
|
|
What is a normal platelet count?
|
150,000 to 300,000 so hold chemo if less than 100,000
bleeding risk if less than 50,000 |
|
|
What are some of the really bad systemic s.e. of chemo?
hint |
Nephrotoxicity-assess creatine, BuN, fluid I&O
Ototoxicity-permanent Pulmonary toxicity/fibrosis (Bleomycin-Bleo lungs) Cardiac toxicity (Adriamycin) Hemorrhagic Cystitis (alkalating agents-usually order 1 L of fluid w/drug) Neurotoxicity(Plant Alkaloids) Extravasation of vesicants given IV which results in necrosis |
Hemorrhagic cystitis- is bad infection in a woman's bladder caused by chemo drugs
|
|
What is a Alkalating agent?
chemo |
Cytoxan-assess for bl. in urine
|
|
|
What is a Antimetabolite agent? chemo
|
Folic acid analogues(methotrexate)
Pyrimidine analogues 5-FU |
|
|
What is an Antibiotic Antineoplastic Agent? chemo
|
Bleomycin, Adriamycin
|
|
|
What are the Hormonal agents used in chemo?
|
Antiestrogens, and antiandrogens
|
|
|
What is a Plant Alkaloid for chemo?
|
Oncovin
|
|
|
What is used to prevent breast cancer?
|
Taxol
|
|
|
The most serious systemic effect of antibiotics is?
|
nephrotoxicity
|
|
|
How do prostaglandins work?
|
activate pain receptors and increase the inflammatory response
|
|
|
Which lab should be checked when there is renal/neprotoxicity problems?
|
creatine levels
|
|
|
Which OTC drugs should you not give if a pt should not take ASA?
|
Kaopectate has Aspirin
|
|
|
What type of drug is Pyridium besides an urinary tract analgesic?
|
AZO standard drug-treats pain
lidocaine effect-calms the bladder |
|
|
If a MAO breaks down epinephrine how does a MAOI work?
|
blocks the break down of epinephrine so do not give with CNS stimulants
|
|
|
AIM (not NSAIDs) means?
|
Abnormal, involuntary movements
|
|
|
two more side effects of thorazine are?
|
hyperprolactinemia-spontaneous lactation, sexual dysfunction
dyskinesias-movement disorders |
|
|
How is the dosage of Artane given?
|
with an intial dose to prevent progression
|
|
|
What eletrolyte is lost with diarrhea?
|
K+
|
|