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27 Cards in this Set
- Front
- Back
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what structure responds to hypothalamic factors released into the blood
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anterior pituitary (adenohypophysis)
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what structure reponds to hypothalamic factors by direct innervatino
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posterior pituitary (neurohypophysis)
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what will the hypothalamus release to cause the release of TSH from the anterior pituitary
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TRH
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what will the hypothalamus relase to cause the pituitary to release LH and FSH
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GnRH
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what will the hypothalamus release to cause the pituitary to release ACTH, beta lipotropin, and beta endorphin
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CRH
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what will the hypothalamus release to cause the pituitary to release Gh
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GHRH
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what will the hypothalamus release to cause the pituitary to not release Gh
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GIH
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all of the releasing hormones from the hypothalamus have ___ c terinal ends, and TRH and GNRH have ____
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amidated/pGLU
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what hormone released by the hypothalamus is a helper to CRH in releasing ACTH from the pituitary
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AVP (arginine vasopressin)
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what is the function of AVP (arginine vasopressin)
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water metabolism
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what hormones are released from the posterior pituitary
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vasopressin and oxytocin
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what type of hormones are Gh and prolactin
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polypeptide hormones
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what type of hormones are TSH, FSH, and LH
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glycoproteins
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what type of receptors do TSH, FSH, and LH bind to?
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G-proteins which stimulate activity of adenylyl cyclase
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ACTH, MSH, liptropin, and endorphins are all derived from
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proopiomelanocortin (POMC)
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TSH, FSH, and LH are composed of 2 subunits, and have the same ___ subunit but different ____ subunits
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alpha/beta
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what residue are the thyroid hormones synthesized from
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tyrosine
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what enzyme is involved in the production of the tyroid hormones
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thyroperoxidase
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iodine is contransported with what into the thyroid follicular cells
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sodium
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what are the products of thyroperoxidase
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T3, T4, MIT, DIT, all on thyroglobulin
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more ___ thyroid hormone is produced, but ___ is more active
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T4/T3
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what enzyme is responsible for the removal of iodine from MIT and DIT
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deiodinase
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what are the two transport proteins that carry thyroid hormone
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thyroxin binding globulin and thyroxin binding pre-albumin
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target tissues for thyroid hormone have the enzyme ___ which will convert T4 into T3
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deiodinase
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thyroid hormone is part of what family
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steroid receptor supergene family
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what effect does thyroid hormone binding have on a cell
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increase gene transcription
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how can thyroid hormone be inactivated
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convert T4 into rT3, total deiodination
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