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19 Cards in this Set
- Front
- Back
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normal human hemoglobin is a ___ of globin chains each with a heme
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tetramer
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what are the three types of hemoglobin found in the embryonic developmental stage
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Hb-Grower-1, Hb-Grower-2, Hb-Portland
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what type of hemoglobin is found in the featl stage of development
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HbF
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what types of hemoglobin are found in the adult stage of development
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HbA and HbA2
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where would you find the alpha gene cluster for humna globin
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chromosome 16
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where would you find the beta gene cluster for human globin
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chromosome 11
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how many exons sequences are located in a typical globin gene
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3 exons
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what specific chains would you find in Hb-Gower-1 hemoblogin
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Zeta 2, Epsilon 2
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what specific chains would you find in Hb-Gower-2 hemoglobin
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alpha 2, epsilon 2
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what specific chains would you find in Hb-portland hemoglobin
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zeta 2, gamma 2
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what two specific globin chains would be found in fetal hemoglobins (HbF)
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alpha 2, gamma 2
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what two specific globin chains would be found in HbA hemoglobin
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alpha 2, betta 2
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what two specific globin chains would be found in HbA2 hemoglobin
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alpha 2, delta 2
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what molecule is associated with the decrease affinity of oxygen
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BPG
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HbF has a higher oxygen affinity than HbA due to the fact that it does not bind
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BPG
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how many alpha helixes are found in alpha and beta globin
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alpha: 7
beta: 8 |
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the nonhelical segments at the ends of the globin chains are called
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NA and HC
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globin chains have different ___ structure, but the ____ and ____ are very similar
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primary/secondary/tertiary
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major contacts in hemoglobin exist primarily between the
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alpha and beta chains, not many alpha-alpha, or beta-beta interaction
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