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19 Cards in this Set

  • Front
  • Back
normal human hemoglobin is a ___ of globin chains each with a heme
tetramer
what are the three types of hemoglobin found in the embryonic developmental stage
Hb-Grower-1, Hb-Grower-2, Hb-Portland
what type of hemoglobin is found in the featl stage of development
HbF
what types of hemoglobin are found in the adult stage of development
HbA and HbA2
where would you find the alpha gene cluster for humna globin
chromosome 16
where would you find the beta gene cluster for human globin
chromosome 11
how many exons sequences are located in a typical globin gene
3 exons
what specific chains would you find in Hb-Gower-1 hemoblogin
Zeta 2, Epsilon 2
what specific chains would you find in Hb-Gower-2 hemoglobin
alpha 2, epsilon 2
what specific chains would you find in Hb-portland hemoglobin
zeta 2, gamma 2
what two specific globin chains would be found in fetal hemoglobins (HbF)
alpha 2, gamma 2
what two specific globin chains would be found in HbA hemoglobin
alpha 2, betta 2
what two specific globin chains would be found in HbA2 hemoglobin
alpha 2, delta 2
what molecule is associated with the decrease affinity of oxygen
BPG
HbF has a higher oxygen affinity than HbA due to the fact that it does not bind
BPG
how many alpha helixes are found in alpha and beta globin
alpha: 7
beta: 8
the nonhelical segments at the ends of the globin chains are called
NA and HC
globin chains have different ___ structure, but the ____ and ____ are very similar
primary/secondary/tertiary
major contacts in hemoglobin exist primarily between the
alpha and beta chains, not many alpha-alpha, or beta-beta interaction