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11 Cards in this Set
- Front
- Back
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what does PDH do?
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converts pyruvate to acetyl CoA
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where is PDH located?
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mitochondrial matrix of cardiac muscle and kidney
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enzymes of PDH complex?
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pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase
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what is the E1 step of PDH?
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TPP in PDH decarboxylates pyruvate to an enol acetate
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what is the E2 step of PDH?
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lipoic acid in dihydrolipoyl transacetylase oxidizes the enol and transfers it to CoA
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what is the E3 step of PDH?
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FAD in dihydrolipoyl dehydrogenase reoxidizes lipoic acid
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what inhibits PDH?
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NADH, acetyl CoA
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what stimulates PDH?
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pyruvate, CoASH, NAD+, Ca2+, insulin in adipose, catecholamines in cardiac
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what is acetyl CoA made of?
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beta-mercaptoethylamine, pantothenic acid, adenosine 3 phosphate 5 diphosphate
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what does CoA exist as?
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reduced thiol
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where does most acetyl CoA come from?
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beta-oxidation of fatty acids
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