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9 Cards in this Set

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What three primary sources produce pyruvate dehydrogenase?
1. Glucose thru glycolysis
2. AA - especially Alanine
3. Lactate via LDH rxn.
What are the 4 most common destinations of pyruvate?
1. Reduced to form lactate (pyruvate+NADH+H => Lactate + NAD

2. Direct transmission to yield Alanine (Pyruvate => Alanine)

3. Carboxylation to OAA (via gluconeogenesis or rxn of TCA) (2Pyurvate + 2CO2 => 2OAA)

4. Oxidative decarboxylation to form Acetyl-CoA (Pyruvate+CoASH+NAD => Acetyl-CoA +CO2+NADH+H)
What is the major gate keeper of the TCA?
Pyruvate dehydrogenase ( mitochondria)
What are the consequences of phosphorylation and dephosphorylation on the pyruvate dehydrogenase complex?
Phosphor = Inactivates
De-Phos = Activates
What is the product of pyruvate dehydrogenase?
Acetyl-CoA
There are Five coenzymes required in the pyruvate dehydrogenase complex, what are they?
1. FAD
2. NAD.
3. TPP
4. Coenzyme A
5. Lipoic acid
Where are the first four of the coenzymes required in the pyr deh complex derived from?
Water soluble vitamins
What coenzymes are needed to deactivate pyr deh activity?
ATP, NADH, Acetyl-CoA
Which coenzymes are needed to re-activate pyr deh activity?
Mg2+, Ca2+, AMP