Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
What three primary sources produce pyruvate dehydrogenase?
|
1. Glucose thru glycolysis
2. AA - especially Alanine 3. Lactate via LDH rxn. |
|
|
What are the 4 most common destinations of pyruvate?
|
1. Reduced to form lactate (pyruvate+NADH+H => Lactate + NAD
2. Direct transmission to yield Alanine (Pyruvate => Alanine) 3. Carboxylation to OAA (via gluconeogenesis or rxn of TCA) (2Pyurvate + 2CO2 => 2OAA) 4. Oxidative decarboxylation to form Acetyl-CoA (Pyruvate+CoASH+NAD => Acetyl-CoA +CO2+NADH+H) |
|
|
What is the major gate keeper of the TCA?
|
Pyruvate dehydrogenase ( mitochondria)
|
|
|
What are the consequences of phosphorylation and dephosphorylation on the pyruvate dehydrogenase complex?
|
Phosphor = Inactivates
De-Phos = Activates |
|
|
What is the product of pyruvate dehydrogenase?
|
Acetyl-CoA
|
|
|
There are Five coenzymes required in the pyruvate dehydrogenase complex, what are they?
|
1. FAD
2. NAD. 3. TPP 4. Coenzyme A 5. Lipoic acid |
|
|
Where are the first four of the coenzymes required in the pyr deh complex derived from?
|
Water soluble vitamins
|
|
|
What coenzymes are needed to deactivate pyr deh activity?
|
ATP, NADH, Acetyl-CoA
|
|
|
Which coenzymes are needed to re-activate pyr deh activity?
|
Mg2+, Ca2+, AMP
|
