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8 Cards in this Set
- Front
- Back
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What components go into synthesizing pyrimidines de novo?
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Amino Acids and Carbon Dioxide
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What is the difference with the beginning of biosynthesis of of purine and pyrimidine?
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Purine begins with ribose where pyrimidine starts with nucleobase. Also, although 5 steps occur in the cytosol, 1 step occurs in the mitochondrion.
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What is the rate limiting step of De Novo Pyrimidine synthesis? What is the most regulated?
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2nd step is commited (formation of N-carbamoyl aspartate
1st step is most regulated (Formation of Carbamoyl Phosphate. |
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What activates the formation of carbamoyl phosphate and what inhibits it?
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ATP and PRPP activates, CTP inhibits.
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Memorize the UMP structure
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Look at the picture.
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How is CTP formed?
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Nucleotide kinases form UTP from UMP. UTP then makes CTP in a one step reaction.
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What adds the Amine to the UTP to form CTP?
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Glutamine
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What is one o
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tleehar
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