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20 Cards in this Set

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1. When acetic acid is applied to the cervix during a colposcopy, what is the purpose of it?
a. Normal squamous cells take it up and become a white layer of cells
b. The cytokeratin expressed by dysplastic cells precipitate form a white opaque layer of cells
c. It turns areas of metaplasia white
d. It is specific for HVP lesions
b. The cytokeratin expressed by dysplastic cells precipitate form a white opaque layer of cells
Which is not an indication for colposcopy?
a. a glandular abnormality on a smear
b. a weird looking cervix
c. dyspareunia
d. 2 LGSIL smears in 12 months
c. dyspareunia
Although, persistent postcoital bleeding would be
What charactersitics are we looking for on a smear? (multi)
a. nucleus/cytoplasmic ratio
b. regularity nucleus
c. excess mitochondria
d. portion of chromatin
a. nucleus/cytoplasmic ratio
b. regularity nucleus
d. portion of chromatin
When do cervical changes indicate the presence of cancer?
a. CIN3
b. metaplastic changes
c. dysplastic changes in the transformation zone
d. a small lesion, that invades the basement membrane
d. a small lesion, that invades the basement membrane
Cell type:
ectocervix
endocervix
ectocervix: squamous epithelium
endocervix: columnar eipthelium
luhols iodine is taken up by
a. normal cells of the endocervix
b. normal cells of the endocervix
c. dysplasic cells only
d. cancerous cells only
mature squamous cells contain glycogen and take up lugols iodine.
a. normal cells of the ectocervix
Which cervical cell type is multilayered & hyperkeratonic?
a. metaplastic
b. dysplastic
c. endocervix
d. normal cervical cells
b. dyspalstic cells are multilayered, hyperkeratonic and have abnormal vasculature
Which of the following are screening tests in pregnancy?
a. foetal blood sampling
b. morphology scan
c. cvs
d. amniocentesis
b. morphology scan
in the triple test which of the following increase the risk of down syndrome?
a. AFP raised
b. BhCG raised
c. Oestriol raised
d. PaPP raised
b. BhCG raised
Triple test: 16 weeks
BhCG: high
Oestriol: lower
AFT:lower

Combined test: 11-13+6 wk
PaPP: lowered (12wk)
BhCG: raised
NT: increased
What is true about nuchal translucency testing?
a. it is reliable at any stage after 12 weeks
b. it is specific to T21
c. an increased NT + normal chromosomes means nothing
d. is not meaningful for the risk of T21 unless it is combined with maternal age and serology
d. is not meaningful for the risk of T21 unless it is combined with maternal age and serology

Further:
a. it is reliable at any stage after 12 weeks- window is 11-13+6 weeks, then it resolves even if there is T21
b. it is specific to T21- NOPE
c. an increased NT + normal chromosomes means nothing- it increases the risk of other congenital defects, so you do serial US at 16,18, 20 weeks
what would the best screening options be for a woman at 8 weeks gestation?
Bloods: FBC, syphilis, HIV, HepB, rubella, rhesus status
Plan: dating US 8-10week
NT + serology:11-13+6 weeks
Morphology scan: 18-20weeks
Risk of miscarriage with:
a. CVS
b. amniocentesis
a. CVS: 1/100
b. amniocentesis: 1/200
what is true of amniocentesis?
a. it is done at 10 weeks
b. 1/200 risk of miscarriage
c. there is a risk of placental mosaicism
d. FISH can be done with CVS but not karyotyping
b. 1/200 risk of miscarriage
Amniocentesis
14 weeks
1/200 risk of miscarriage
Results:
FISH in 1 day
Karyotyping 2-3 weeks
A high risk woman wants karyotpying at 15 weeks, does she need CVS or amniocentesis?
CVS: 10 weeks on
Amniocentesis: 14 weeks on
What does down syndrome mean for the kid? laymans terms
Physical and neurodevelopmental problems
Physical: heart defects, duodenal atresia, facies, short stature
Neurodevelopment: low IQ, ect.
No treatment
There is a test
Can consider termination of pregnancy
prevalence of preterm birth in Australia?
7%
What antibiotics do you give in threatened preterm birth?
ampicillin
gentamicin
under what gestational age do you expect a baby to have trouble sucking?
36 weeks
premature neonate problem: 26 weeks (immediate)
potential:
1. thermal instability
2. asphyxia- need rescus
3. respiratory distress syndrome (lung collapsed)- treat with surfactant, oxygen therapy:CPAP
4. metabolic disturbances: more likely to by hypoglycaemic, hypocalcaemic, hyponatraemic, and acidotic- monitor and treat
5. higher change of jaundice, treat if the levels get high to prevent brain damage: exchange transfusion or phototherapy
6. feeding problems: tube feeding as babies get suck/gag reflex around week 36
7. renal immaturity
8. patent ductus arterosus: will close with prostaglandins
9. decreased immunity, increased chance of infection
10. higher risk of intraventricular haemorrhage- cool baby at first signs of oedema
11. risk of retinopathy of the newborn, due to eye vessels growing too fast in response to oxygen- incubators can control oxygen exposure, treatment is available
premature neonate problem: 26 weeks (long term)
long term:
increased risk of respiratory problems, otitis media, feeding problems, reflux, need for hearing aid
Increased risk of low IQ, learning difficulties and ADHD
Development impairment: 10% severe, 20% mild/moderate
BUT
they WILL catch up growth wise by around the age of 3
>90% attend normal school programs and there is no significant difference in self esteem. Also, there is a decrease in risk taking behaviour in these children as they grow up.