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218 Cards in this Set

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When does hyperemesis typically occur in early pregnancy?
6-12 weeks
What can be used to treat hyperemesis in pregnancy?
An anti-emetic, like maxalon which is safe in pregnancy
When does a mother generally start to feel foetal movements?
18-20 weeks, depending on placental location
What is a pregnancy test measuring?
beta-HCG
How early can home pregnancy tests detect a pregnancy?
Two weeks
When taking an obstetrics history what does G3 P2 mean?
Gravidity= 3: number of pregnancies
Parity: 2: live births (at any stage of gestation) or still births after 24 weeks.
What antenatal serology is taken?
Antentatal serology
- Rhesus
- HIV
- HepB, C
- Syphillus
- Variecella
- FBC
How long does bHCG stay +ve after abortion or miscarriage?
Remains positive for ≈5d. after miscarriage/abortion or foetal death.
When is a dating US done?
8-10 weeks
In a nm pregnancy what happens to B-hCG, and for how long?
B-hCG doubles every 48 hours for the first 8 weeks
What key pre-existing medical conditions need to be addressed in pregnancy? (4)
1. diabetes
2. hypertension
3. epilepsy
4. thyroid disease
What day of the menstrual cycle does ovulation occur on?
Day 14
How long does an egg live for in utero?
Semen?
Egg: 12-24 hours
Semen: 3 days
What days should a couple have sex on when trying to conceive?
10, 12, 14, 16
How long does corpur luteum persist for in pregnancy?
10 weeks
After conception, when does implanation occur?
Day 6
How does the maternal system react to conception?
1. progesterone to keep corpus luteum alive
2. modify trophoblast expression of HLA antigens to facilitate maternal tissue acceptance of the fetal graft.
3. occasional there is an implantation bleed
How long does the embryonic period last?
8 weeks post conception
10 weeks post last menstrual period
What does the primitive streak occur in embryonic development?
2 weeks
When does the heart develop?
3 weeks
How long is the human gestational period? (days, weeks)
280 days
40 weeks
Are maternal and foetal circulation in continuation?
Nope, they are completely separated.
How does the placental develop?
Trophoblasts invade the endometrium as fingerlike projections (vili)
What are the functions of the placenta? (5)
1. gas exchange
2. provision of nutrients
3. waste disposal
4. hormone synthesis: HCG, progesterone, oestrogen, etc.
5. drug transfer
What percentage of the worlds population are rhesus -ve?
15%
How do you treat rhesus -ve women, and when?
Administer Anti-D at 28 weeks, and 34 weeks.
When is the uterus palpable above the symphis? at the umbilicus?
symphis: 12 weeks
umbilicus: 18-20 weeks
How long is the sac making amniotic fluid?
until about week 16, after than the baby is making it.
what changes occur in the cervix during pregnancy?
- softening
- cyanosis
- shortening
- proliferation of glands
- formation of mucus plug
What changes occur in the vagina during pregnancy?
- increased vaginal discharge
- changes colour
- becomes more vascular
- thickening of vaginal mucosa
- loosening of connective tissue
- hypertrophy of smooth muscle
What skin changes occur during pregnancy?
1. stria gravidarum
2. diastasis recti
3. pigmentaion
Cervical changes in pregnancy
Reduction in cervical collagen towards term enables its dilatation.
Hypertrophy of cervical glands leads to the production of profuse cervical mucus and the formation of a thick mucus plug or operculum that acts as a barrier to infection.
Vaginal discharge ↑ due to cervical ectopy and cell desquamation
Breast changes in pregnancy?
- tenderness
- antenatal secretion of clostrum
- increase from week 8
- areolar becomes more pigmented
Metabolic changes in pregnancy?
1. weight changes: uterine hypertropy & contents, fet deposition, fluid retention
2. fluid retention:
- decreased plasma osmolality
- increased maternal blood volume
- pitting oedema
Haematological changes in pregnancy? (6)
Prothrombotic state:
1. blood volume up by 40-45%
2. RBC increase by 33%
3. increased platalets
4. increased ESR
5. increased fibrinogen
6. decreased fibrinogen
Cardiovascular changes in pregnancy?
- HR up 10-15bpm
- increased SV & CO
- decreased peripheral resistence
- decreased BP for first 20 weeks
- exaggerated splitting of the first heart sound.
- systolic ejection murmur
What percentage of pregnant woman have a systolic ejection murmur?
90%
Respiratory changes in pregnancy?
There aren't actually any, but they may be perceived due to the baby pressing up against the diaphragm
Renal changes in pregnancy?
- increased renal size
- increased renal blood flow
- increased GFR
- decreased serum creatinine and urea
GI changes in pregnancy?
Displacement
Delayed gastric emtpying and intestine transit times
Reflux & heart burn are common
Constipation/ haemorrhoids
What are some minor disorders of pregnancy?
1. nausea
2. vomiting
3. oesophageal reflux
4. constipation
5. epistaxis (nose bleed)
What is the standard antenatal visit schedule in a normal low risk pregnancy?
First visit: 12-16 weeks
4 weekly till 28 weeks
2 weekly till 36 weeks
weekly until term
When is nuchal translucency investigated?
11-14 weeks
When is the foetal morphological scan undertaken?
18-20 weeks
When are routine FBC's done?
First visit
week 28
week 36
When is Anti-D given
to rhesus -ve mothers
week 28
week 36
when is glucose testing done?
28 weeks
How do you test for Group B strep?
Low vaginal swab
What are the phases of labour in the first stage?
How long does the first stage last on average?
Latent phase & active phase (when cervix is >3cm dilated)

Nulliparis: 12 hours
Multiparis: 6 hours
How long does the second stage last on average?
Nulliparis: 20-120 minutes
Multiparis: 10-60 minutes
When is oxcytocin administered in the 2nd stage, and why?
Administered with the delivery of the anterior shoulder and helps with the delivery of the placenta.
How long should the 3rd stage of labour last?
less than 30 minutes.
prevalence of ovarian cysts worldwide?
7%
What genetic mutations are associated with ovarian cancer?
BRCA-1
BRAC-2
Lynch II syndrome
What are the two common functional ovarian cysts?
follicular cysts
corpus luteum cysts
What is most common type of ovarian cyst?
Follicular
24%
What makes a follicular cyst?
An unruptured Graddian follicle that continues to secrete fluid
Are follicular cysts generally bilateral?
Nope, usually unilateral.
What are the most common types of benign ovarian neoplasms?
serous cystadenoma & mucinous cytadenomas make up 40% and are the most common.
Follicular cysts, features:
unilateral
<5cm
secrete oestrogen
may result in longer menstrual cycle
40 year old with bilateral moderately sized cyts, and no disruption of her cycle. What is it?
Serous cystadenoma
- 30% bilateral
- moderate size
- 35-55yrs
- secrete a thin watery fluid
35 yr old women with a large multilocular ovarian cyst. What is it most likely?
Mucinous cytadenoma
- big and multilocular
- usually unilateral
- secretes mucin
What causes pseudomyxoma pertonei?
when a mucinous cytadenoma
ruptures and mucinous cells attach to the peritoneum and omentum.
What are chocolate cysts?
endometriomata
A 30yr old presents with bilateral ovarian cysts or moderate size, which contains atypical tissue. What is it likely?
Benign teratoma
What is a fibromata?
characteristics?
a connective tissue neoplasm of mesenchymal origin.
- usually small
- 10% are bilateral
How many women presenting with polycystic ovaries have PCOS?
1/3
What are s/s of polcystic ovaries? (4)
Pelvic pain
Bloating
Early saitey
Palpable adnexal mass
what are risk factors of polycystic ovaries? (7)
pre-menopausal
early menarche
1st trimester of pregnancy
PCOS
increased intrinsic/extrinsic gonadotropins
tamoxifen therapy
What is the equation for the risk of malignancy index?
RMI= UxMxCA125
U: ultrasound score
M: menopausal
CA-125: serum CA-125 measurement as marker of epithelial ovarian ca.
US signs that increase the risk of an ovarian cyst having malignant potential?
1. multi-locular cyst
2. evidence of solid areas
3. evidence of metastases
4. presence of ascites
5. bi-lateral lesions
How to treat polycystic ovaries?
Observe with repeat US
Suppress with OCP
Laparoscopic ovarian cystectomy
Laparoscopic oviectomy
Fibroids: details?
Aka. leimyomata, fibromyomas
Most common pelvic tumour in women (30-70%)
Malignant changes are rare
Related to E and P
Shrink after menopause
Most common pelvic tumour in women (30-70%)
Fibroids
When do you treat fibroids?
When the symptoms are unpleasant (intramenstrual bleeding, miscarriage, compression of bladder, pain, constipation)

when it is affecting fertility
What are some drugs therapies for fibroids?
NSAIDs, tranexamic acid
OCP, mirena IUD, progestins
GnHR agonist/antagonists
what is preterm?
<37 weeks
what is postterm?
>42 weeks
low birth weight=
very low birth weight=
extreme low birth weight=
LBW=<2500gm
VLBW=<1500gm
ELBW= <1000gm
Risk factors for small babies (both small for gestational age and premature)
Socioeconomic: poverty, teenage mums, single mothers, smoking, drug use
Medical: hypertension, renal, autoimmune
Placental/uterus: infection, multiple gestation, placental abruptio, placenta praevia
Foetal: chromosomal abnormalities, cardiac problems, etc.
What are the broad issues involved with preterm delivery for the feotus?
1. Asphyxia
2. Thermal instability
3. Pulmonary disease: respiratory distress syndrome/ hyaline membrane disease
4. Metabolic disturbances
5. GI: jandice, necrotising enerocolitis
6. Renal immaturity
7. Cardiac: patent ductus arterosus
8. Haematological
9. Infections
10. Neurological/ neurosensory
11. Retinopathy of prematurity
12. Sensori-neural hearing loss
How do manage potential metabolic disturbances in a premature baby?
Monitor blood sugars and electrolytes
When do babies get their suck reflex?
36 weeks
What is a potential serious neurological result of prematurity?
Intraventricular haemorrhage: bleeding into the ventricles which results in hydrocephalus and potentially a stroke.
What causes retinopathy of prematurity?
vessels being grown too fast in response to oxygen, leads to retinal detachment resulting in blindness
What is the accepted cut off for potential survival of premmie?
23 weeks
When is a preterm baby considered viable? ie. parents can't decide to withdraw care
25 weeks
Preterm babies between 23-25 weeks suffer what complications?
1. chronic lung disease: 50-70%
2. infection: 30-50%
3. intraventricular haemorrhage:10-30%
4. retinopathy of prematurity: 10-50%
5. necrotising enterocolitis: 5-10%
What are some long term respiratory problems associated with premature birth?
Asthma
Chronic lung disease
Home oxygen therapy
Increased risk of infection
Do respiratory problems associated with premature birth persist?
overt lung abnormalities resolve over 1-2 years
Do premature babies catch up in terms of growth?
Yes, over 1-3 years with additional nutrition
When are vaccinations given to a preterm baby?
According to chronological age, not gestational.
What % of extreme low birth weight babies require hearing aids?
2-4%
what is the relationship between birth weight and cerebral palsy?
ELBW: 50/1000
LBW: 8/1000
NmBW: 1.5/1000
Is cerebral palsy detected at birth?
Nope. May not be picked up on neurological exam until 8-12 months.
What % of miscarriages have a chromosomal abnormality?
50%
What % of still births have a chromosomal abnormality?
5%
What % of live births have a chromosomal abnormality?
0.5%
What is the best early screening test for chromosomal abnormalities?
NT+biochemistry
Detect 90-94%
2.5-5% false positives
7 unnecessary tests
What is NT? When is it done?
nuchal translucency testing
11-13 weeks
Can you use maternal age as a screening tool for T21?
No, 45% of DS babies are born to mothers <35yrs.
Only detect 55%, get 18-22% false positives, do 79 unnecessary tests.
Why do you do first trimester tests?
Do look for foetal death, multiple pregnancies, or morphological abnormalities.

Early detection give parents privacy to make difficult decisions.
What percentage of NT tests come back low risk?
95%
Where is it harder to get NT?
The country, as you require a very skilled sonographer
NT 3.9 at 12 weeks: high or low risk T21?
High, if maternal age is 31:
went from 1/528
to 1/24
First trimester screening: what should to look for chromosomal abnormalities?
Combined test:
11-13+6 weeks:
Pregnancy-associated plasma protein A (PaPP-A) + free B-hCG- risk calculation
Nuchal thickness (increase=+ve)

Performance ˜90% detection for 5% FPR .

May detect other abnormalities such as anencephaly.
Acceptable detection of all trisomies.
Disadvantage: expensive and difficult to perform nuchal scan
Should you do T1 testing or T2 testing?
both is best, increases detection rate from 90 to 96.3%
Beyond NT, what else can be picked up on US to suggest T21?
(3)
1. Nasal bone (5-6weeks) will be shorter and less mineralised in T21
2. Abnormal ductus venosus
3. Tricuspid regurg
What is CVS and when is it performed?
It is sampling of chorionic vili, and chromosomes are analysed from cultured cells.


11-14 weeks
EARLIER than amniocentesis
What is amniocentisis, and when is it performed?
Sampling of amniotic fluid (20mls). Chromosomes analysed from cultured cells.

15+ weeks
Why is fetal blood sampling done? When is it done? Is it common?
Uncommon now
Done from 18 weeks
Is done when there is risk of foetal transfusion (like in rhesus mothers).
What is the gold standard for analysis of chromosomes in samples (CVS, amnio)?
Classic cytogenics- but is expensive, and slow, and highly operator dependent.
What is the miscarriage risk with CVS?
<1%
What is the miscarriage risk with amnio?
<0.5%
What is the miscarriage risk with feotal blood sampling
2% is foetus is well
20% if hydrophobic foetus
What normally happens to BP in pregnancy?
Drop in both SBP and DBP in first trimester
Normalises in second trimester
Approaches pre pregnancy BP in third trimester
Prevalence of gestational HTN?
9.8%
Severe HTN?
SBP > 170 mmHg
DBP>110 mmHg
In pregnancy a change of how much is defined as HTN? And from when?
30/15mmHg
from BOOKING BP, not pre-pregnancy BP
Define gestational HTN?
HTN after 20 weeks without associated systemic changes
If gestational HTN is still present 15 weeks after the birth, is this normal?
Not for gestation HTN
Not it is chronic HTN
This cut off is at 12 weeks post partum
When is gestational HTN at risk of becoming pre-eclampsia?
If it is present early in pregnancy, or is severe.
What % of severe gestational HTN diagnosed <30weeks go onto PET?
40%
If gestational HTN is dx >37 weeks what % will go onto PET?
10%
HTN <20 weeks, with no known cause is?
Essential HTN
secondary HTN <20weeks may be caused by what?
1. chronic kidney disease
2. renal artery stenosis
3. SLE
4. DM
5. Cushings syndrome
6. Primary hyperaldosteronism
7. coarctation of the aorta
What variables should be controlled when measuring BP in pregnancy?
Right arm always
Patient sitting, relaxed
When should you measure BP on both arms in pregnancy? Why?
On the first visit, to exclude coarcation of the aorta
If you have a woman with pre-exisiting HTN, and proteinuria, what do you do?
She is at higher risk of PET
Diagnose on other systemic/foetal features: such as IUGR
Define pre-ecplamsia
HTN that occurs >20 weeks gestation with systemic signs, such as
- proteinuria
- haematological involvement
- liver signs: LFTs or pain
- neurological involvement
Is a raised Alk phos of concern in pregnancy?
Nope, it is normally raised in pregnancy
What is the prevalence of pre-eclampsia in aus?
4.2%
What % of maternal deaths in low and middle income countries is due to PET?
99%
Risk factors for PET
Previous PET
>10yrs since last baby
Age: >40
BMI>35
Family history
Underlying medical disorder
What can be used as prophylaxis for PET?
Arpirin has a use
Calcium, Vit C and Vit E have been shown to NOT be useful
What is involved in surveillance of a woman with PET?
1. BP measured 2-3x week in day assessment unit
2. Education about signs and symptoms
3. Blood investigations: FBC, UEC, LEFTs, Urate
4. Urinalysis: spot protein, creatinine
5. CTG and or US to monitor foetal growth
Education about signs and symptoms of PET for mother should include what?
- headaches
- visual spotting
- visual blurring
- epigastric pain
- dizziness
Pathology of PET
1. immunological: foreign body reaction
2. Placental: poor implantation, poor invasion by throphoblastis
Is oedema a key component of PET?
It occurs in PET, BUT is not part of the diagnosis because it is so common in pregnancy and is probably of little clinical importance.
How do you diagnose PET>
diagnosis of exclusion
What are the patho-physiological changes that distinguish PET from normal pregnancy?
1. intense vasopasm
2. intravascular coagulation
Why is there increased intravascular coagulation in PET?
platelets are on hand to repair the vasculature in the placenta
what happens to the plasma volume in women with PET?
In normal pregnancy plasma volume increases (40-45%)
In women with PET there is slight or unchanged plasma volume
Thus haemoconcentration!!
How does the change in blood in PET affect the kidneys?
Kidneys are super sensitive little fellas
- protein > +1
- spot protein/creatinine ration >30mg
- creatinine >90
What is HELLP syndrome?
HELLP syndrome is a group of symptoms that occur in pregnant women who have:

H -- hemolysis (the breakdown of red blood cells)

EL -- elevated liver enzymes

LP -- low platelet count
What liver enzymes are we looking at in PET?
AST>40 U/L
ALT >40 U/L
ALP will probably be up anyway as a result of pregnancy
What is the end-point of PET?
ECLAMPSIA- Cerebral changes!
What occurs with eclampsia?
Seizures
What are the cerebral changes associated with PET?
hyperreflexia WITH clonus
persisting headache
visual disturbances
diminished level of conscoiusness
What haematological problems are associated with PET?
DIC!
What effect can PET have on the foetus?
IUGR
Foetal hypoxia
Prematurity
Placental abruption
Intrauterine death
Is an epidural recommend or illadvised in PET patients?
Recommended, you dont want a pain related increase in BP
What antihypertensives are first line in PET?
Methyldopa- oldest
Oxyprenolol
Labetolol
Second line PET meds
Hydralazine
Nifedipine
Prazosin
Drug therapy for severe PET?
Jump straight to second line:
Hydralazine
Nifedipine
Prazosin
What BP meds are contraindicated in pregnancy?
ARBs
ACEi
Acute Rx for SEVERE HTN in pregnancy?
IV labetolol (50mg, repeat after 15-30mins)
IV Hydrazaline (5-10mg, repeat after 30 mins)
IV Diazoxide (15-45mg, repeat after 5 mins, max 300mg)
Tab Nifedipine (10-20mg, repeat after 45 mins)
PET indications for delivery
GA>37weeks
Cant control the HTN
Decrease in platelets- worry about DIC
Decrease in LFTs, renal funct.
Placental abruption
Persistent neurological symptoms
Pulmonary oedema
Eclampsia
IUGR
Rx for eclampsia
Usually self limitiing seizures
If long: IV diazapan or clonazapem
Magnesium sulphate- prevents further seizures!
MgSO4
CNS depressant
used:
- following a seizure, to prevent the next one
- maintenance
- in anticipation of delivery
MgSO4 toxicity
hypotension
flushing
slurred speech
absent reflexes
If a baby grows normally in initially, but is growth restricted in the last trimester, what has caused this?
placental dysfunction/ insufficiency
Fetal growth depends on?
1. genetics
2. nutrients (O2 and glucose esp)
3. A good foetal circulation
4. Functioning fetal pancreatic B-cells
5. a good blood supple to placental and transfer accross it
What is the relationship between insulin and interutero growth
Insulin is one of the main regulators of feotal growth
What is the most common cause of IUGR?
maternal hypertensive disorders
Will all hypertensive women have small babies?
No, the degree to which this affects foetal growth depends on the amount of placental functioning reserve.
What makes a IUGR foetus likely to die in utero?
They are more likely to develop metabolic disorders:
- acidosis
- hypoglycaemia
- erythroblastosis
macrosomic
large baby
DMII
Is being a normal for size baby in a high risk pregnancy better or the same risk wise, than being IUGR?
Better
What additional tests should be done to access foetal well being in a high risk pregnancy?
>30 weeks
- foetal movement counts
- cardiotocography
- serial ultrasound examinations
- doppler flow velocity wave forms
How many times should a baby kick in a day, past 30 weeks?
10-130
<10, needs to have a cardiotographic assessment
Naegele's rule?
(LMP + 1yr 7days) – 3 months
Gravidity
Number of pregnancies, including the current one
Parity
Number of births beyond 24 weeks gestation (including still births)
Linea nigra
dark pigmented line stretching from the xiphi sternum through the umbilicus to the suprapubic area
striae gravidarum
recent stretch marks are purplish in colour
striae albicans
Old stretch marks are silvery, white
What is the difference between foetal lie and presentation?
Lie: what direction the foetal pole is in
Presentation: part of foetus overlying the pelvic brim
polyhdramnios
excess of amniotic fluid in the sac
Pawlick's manoeuvre
The presention foetal partis moved between the fingers and thumb of the examiners hand, to determine whether it is the foetal head or breech
Naegele's rule?
(LMP + 1yr 7days) – 3 months
Gravidity
Number of pregnancies, including the current one
Parity
Number of births beyond 24 weeks gestation (including still births)
Linea nigra
dark pigmented line stretching from the xiphi sternum through the umbilicus to the suprapubic area
striae gravidarum
recent stretch marks are purplish in colour
striae albicans
Old stretch marks are silvery, white
What is the difference between foetal lie and presentation?
Lie: what direction the foetal pole is in
Presentation: part of foetus overlying the pelvic brim
polyhdramnios
excess of amniotic fluid in the sac
Pawlick's manoeuvre
The presention foetal partis moved between the fingers and thumb of the examiners hand, to determine whether it is the foetal head or breech
What are the leading causes of death in indigenous women? in order
1. cardiovascular disease
2. malignant neoplasm
3. endocrine, nutritional, metabolic
4. smoking
how do cervical cancer rates in indigenous women compare to their non indigenous counterparts?
5x
what is the prevalence of cervical cancer in indigenous women?
10.2%
Indigenous mothers:
Age?
Delivery method?
Younger. 24.8yrs is average
Less likely to be induces, less likely to have CS
What are the socioeconomic complications of teen mothers?
<15 biologically immature
>15: poor preconception health care
Poor education= financial difficulties
socially vulnerable and stigmatised
what % of indigenous mothers smoke?
57%
maternal mortality, indigenous vs non-indigenous?
2x as many indigenous
what is the average distance an indigenous mother travels to deliver?
4 hours
What % of indigenous mothers travelling to give birth, birth en route?
12%
Low birth rate risk factors
socioeconomic disadvantage
size & age of mother
mothers nutrition
illness during pregnancy
duration of pregnancy
drugs: EtOH, tobacco, others
What is unique about STI's in indegnous women?
1/4 of women in remote communities have an STI
They present acutely:
- disseminated gonococcal infection
- PID
- ICU admission for the complication of sepsis
How much of a problem is domestic violence in indigenous populations?
24% of ASTI>15yrs have been the victim of threatened or physical violence
Risk factors for domestic violence?
being young
being removed from your family
unemployment
poverty
What kind of incontinence is treated with retraining?
urge incontinence
How do you treat stress incontinence?
pelvic floor exercises
If pelvic floor muscles fail to manage incontinence, what is your next step?
Stress incontinence:
- Uridynamics
- Surgical sling
If you have mixed type urinary incontinence, which do you treat first?
Treat urge first (retraining, anticholinergics) then stress
What happened in an overactive bladder?
detruser over activity: urge incontenence
involuntary leakage of urine
What are pregnancy risk factors for incontinence?
Large baby: >4000g
3rd degree tear
forcepts
long second stage
Which routine test gives you a clinical suspicion of urge incontinence due to overactive bladder?
stress provocation test
What is urodynamics?
Pressure flow study to work out detrusor pressure
How do you work out detrusor activity in urodynamics?**
pressure in bladder= abdominal pressure+detrusor pressure

use a abdominal line (vaginal/rectal) and a bladder line and then subtract to get the detrusor pressure
when is improvement seen after commencing pelvic floor muscle exercises in stress incontinence?
1 week
what are the drugs used to treat OAB?
antimuscarincs/ anticholinergics:
propanthene, oxybutin, solifenacin

tricyclic antidepressants
define premature
born before 37 weeks
define preterm
not in labour
prevalence or premature labour?
7.5%
risk factors for prematurity?
Multiple births is the big one! IVF
PROM
spontaneous preterm labour
cervical incompetency
IUGR
Pre-eclampsia
Antepartum haemorrhage
Long term effects of prematurity
Chronic lung disease
Neurological deficit: hearing, vision, epilepsy, cerebral palsy