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14 Cards in this Set
- Front
- Back
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TNF-alpha
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Mimics sepsis syndrome; Margination of Neutrophils is particularly striking after TNF-apha administration
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IL-1
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Fever, increased adhesiveness of endothelial cells and leukocytes; endothelial pro-coagulant activity
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IL-2,6,8
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Hypotension, capillary leak, decreased myocardial contractility, synthesis of "acute phase" proteins (fibrinogen) by the liver, leukocyte chemotaxis
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Hageman factor (XII), tissue factor, factor X
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Coagulation , fibrinolysis
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compliment cascade
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Neutrophil chemotaxis and aggregation; capillary leak
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Endorphins
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hypotension
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leukotriens and thromboxane
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platelet aggregation, neutrophil adhesion, capillary leak, decreased myocardial contraction
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prostaglandins (E2, I2)
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Hypotension, neutrophil adhesion to endothelium, fever, muscle aches and proteolysis
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Bradykinin
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hypotension, capillary leak
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serotonin
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pulmonary hypertension, capillary leak
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histamine
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hypotension, capillary leak
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PAF
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hypotension, capillary leak, platelet aggregation, leukocyte activation, decreased myocardial contractility
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Endothelin 1
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Vasoconstriction, especially the kidney
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endothelial relaxing factor
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hypotension
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