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5 Cards in this Set
- Front
- Back
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Adenosine deaminase
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converts adenosine to inosine
ADA deficiency leads to accumulation of rA and dA dA is salvaged to dATP which inhibits Ribo Rtase (then def in dCTP,dTTP and dGTP) -->SCID |
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Lesch Nyan syndrome
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deficiency in HGPRTase
Xlinked severe gouty arthritis, mental retardation and aggressive self mutilation |
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Ribonucleotide reductase
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catalyzes formation of all deoxynucleoside diphosphates
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Xanthinuria
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Xanthine oxidase deficiency
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Ribonucleotide reductase
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ATP turns it on
favors dCDP and dUDP dUDP-->dUMP-->TTP TTP favors dGDP (-->dGTP) dGTP favors dADP(-->dATP) dATP turns off by displacing ATP |
