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32 Cards in this Set
- Front
- Back
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哪些药物会引起PAH?
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diet drugs: dexfenfluramine, Fen/Phen
cocaine methamphetamine |
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PAH最终后果
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heart failure -- death
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PAH的一个显著症状
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Raynaud's phenomenon
供血不足导致手指脚趾冰冷变色 |
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Prostacyclin analogues MOA
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expand lung vessels and allow blood to move through lungs with less resistance
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Epoprostenol的给药方式
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IV
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Treprostinil的给药方式
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SC
IV |
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Iloprost的给药方式
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inhalation
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Epoprostenol的注意事项
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avoid interruptions in therapy
避免忽然大幅降低剂量 |
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Prostacyclin analogues side effects
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flu-like symptoms
jaw pain |
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Iloprost的特殊副反应
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Lockjaw (trismus)
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Prostacyclin analogues同哪些药物有additive effects
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antihypertensives
antiplatelets |
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Endothelin receptor antagonists MOA
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block endothelin - a vasoconstrictor
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Bosentan preg. cat.
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X
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Ambrisentan preg. cat.
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X
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Bosentan不可和哪些药物同用
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cyclosporine
glyburide |
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bosentan慎用于
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肝功能不全
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bosentan需monitor
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LFT
bilirubin Hgb |
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Ambrisentan需monitor
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LFT
Hgb |
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bosentan side effects
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Hgb下降
LFT上升 nasopharyngitis |
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bosentan regulation
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REMS drug
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ambrisentan side effects
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LFT上升
外周水肿 nasal congestion sinusitis |
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哪些药物会增加bosentan浓度?
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2C8/9 inhibitors
3A4 inhibitors |
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哪些药物会增加ambrisentan浓度?
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potent 3A4 inhibitors
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bosentan和ambrisentan谁的drug interactions多?
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bosentan
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PDE-5 inhibitors MOA
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inhibit main phosphodiesterase in pulmonary vasculature --> cGMP升高 --> vasodilation
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PDE-5 inhibitors side effects
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血压急剧下降
runny nose back pain (Adcirca) Priapism 视觉:忽然失明(需立即就医), 实力模糊,怕光,bluish haze,暂时蓝绿色盲 听觉:单耳失聪,耳鸣 |
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sildenafil慎用于
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CAD病人
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PDE5-Is的absolute contraindication是
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nitrate 包括:
nitroglycerin isosorbide mononitrate isosorbide dinitrate illicit drugs: amyl nitrate, butyl nitrate (poppers) |
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如使用sildenafil或vardanafil后需nitroglycerin
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24小时washout
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如使用tadalafil后需nitroglycerin
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48小时washout
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PDE5-Is和alpha-blockers同用会怎样
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tamsulosin(Flomax), doxazosin(Cardura)
additive effect:减低血压 如需同用,先用一种,稳定后,从最小剂量开始加入另一种 |
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Tadalafil用于什么样的病人需减量
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肝肾功能不全
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