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16 Cards in this Set
- Front
- Back
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Acetyl CO-A (Acetyl coenzyme A) |
Precursor necessary for ACh synthesis. |
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Acetylcholine |
Neurotransmitter involved with the central and peripheral nervous system and synthesized by the cholinergic neurons. It is the target of many of the deadliest neurotoxins. |
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Acetylcholinesterase (AChE) |
Enzyme that controls levels of ACh by breaking it down into choline and acetic acid. |
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Atropine |
Drug that blocks muscarinic receptors (is an antagonist) |
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Choline |
Precursor necessary for the ACh synthesis |
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choline acetyltransferase |
Enzyme that catalyzes the synthesis of acetylcholine from acetyl coenzyme A and choline |
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How is Choline Acetyltransferase transported? |
It is transported through a neuron in a Vesicular Acetylcholine Transporter (VAChT) |
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Choline transporter |
Protein in the membrane of the cholinergic nerve terminal involved with the uptake of choline from the synaptic cleft |
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Laterodorsal tegmental nucleus |
Structure within the dorsal lateral pons containing cholinergic neurons that project to the ventral tegmental area |
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Basal Forebrain Cholinergic System |
Collection of nerve cells that supply the cerebral cortex and the hippocampus (specifically) with nerves. Damage to this system contributes to the symptoms of Alzheimer's Disease. |
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Muscarinic Receptors |
Family of metabotropic cholinergic receptros that are selectively stimulate by muscarine |
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Parasympathetic agents |
Drugs that block muscarinic receptor, inhibiting the parasympathetic system |
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Soman |
Toxin that causes irreversible inhibition of AChE (Acetylcholinesterase). It is used as a nerve gas for chemical warfare |
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Vesicular Acetylcholine Transporter (VAChT) |
Vesicle membrane protein that transports ACh into synaptic vesicles. |
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How many subtypes do the muscarinic receptors have? |
5 |
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Properties and function of: Nicotinic receptors |
Ionotropic, pentameric, |
