Psychopharmacology

Front 1

buspirone

Back 1

Anxiolytic
partial agonist for serotonin 5-HT 1A receptors in the CNS
reduces anxiety states without the sedation seen with benzodiazepines

Front 2

benzodiazepines
mechanism of action

Back 2

bind to the GABAA receptor which is composed of 5 protein subunits (that includes two alpha subunits; two beta subunits; and a gamma protein that together form a chloride channel.

Front 3

benzodiazepines, non-benzodiazepines, and barbituates
mechanism of action

Back 3

receptor "agonists" which hyperpolarize neuron membranes (via chloride influx) and suppress their activity.

Front 4

benzodiazepines
therapeutic effects

Back 4

BDZs are used to treat anxiety disorders (including alcohol withdrawal symptoms), induce sedation and skeletal muscle relaxation (motor control centers in CNS), and control some seizure disorders

Front 5

Non-benzodiazepines
therapeutic effects

Back 5

induce sedation and hyponosis (sleep) with a rapid onset of action and fewer prolonged psychomotor depressant effects seen with BDZs and barbiturates

Front 6

Selective Seritonin Reuptake Inhibitors and Selective Norepinephrine Reuptake Inhibitors
Theapeutic effects

Back 6

have anxiolytic effects with low potential for abuse and dependence; when compared to BDZs they have little affect on memory and motor activity

Front 7

Barbituates
Therapeutic effects

Back 7

used to induce
sedation/hyponosis/surgerical anesthesia (thiopental) and they can serve as an anticonvulsant(phenobarbital) medication

Front 8

Barbituates and Benzodiazepines
Pharmacotoxicology

Back 8

can induce prolonged sedation (“hang-over”) and anterograde memory disturbances; these medications can cause sleep disorders (alterations in REM sleep)

Front 9

Barbituates
Pharmacotoxicolgy

Back 9

barbiturates can induce euphoria and addiction; this class of medications are microsomal enzyme (CYPs) inducers and can alter metabolism of other drugs

Front 10

Benzodiazepines
Drug Interactions

Back 10

BDZ's CNS effects can be extended by CYP enzyme inhibitors that
include cimetidine and oral contraceptives

Front 11

The motor side effects produced by antipsychotics are mediated by the GABA receptor
TRUE or FALSE

Back 11

FALSE monitored by dopamine

Front 12

Phenothiazides
Mechanism of action

Back 12

act as D2 dopamine receptor antagonists in many areas of the CNS that possess dopamine (DA) pathways;