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4 Cards in this Set
- Front
- Back
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Liver
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Break down drugs before get to brain
Enzymes: cytochrome P-450 family 1,2,3, Main 2 - CYP2D6 & CYP34A more than 50% Substrates - things that are broken down Metabolites - what's left over Active metabolites - will go through again and have action Induce: St. John's Wort Raises level of enzyme --> drugs broken down. Can influence dosing of drugs i.e. b/c Inhibit: Grapefruit Lowers level of enzyme--> drugs not broken down enough. May cause toxicity |
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Dopamine
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Nigrostriatal: Substantia nigra - basal ganglia
Motor control/planning Mesolimbic: Midbrain - limbic Emotional Control, euphoria, hallucinations Mesocortical: Midbrain - Frontal Lobes Cognition/Attention Tubero Infundibular: Hypothalamus - Pituitary Hormone Regulation, Sexual Functioning NMLMCTI Example: Antipsychotics (Haloperidol) |
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Norepinephrine
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Frontal: Locus Coeruleus - Frontal
Mood Regulation, Cognition/Attention Limbic: LC - Limbic Emotion, Fatigue, Psychomotor agitation, fight/flight Cerebellar Pathway: LC - Cerebellum Motor coordination/control Brainstem & Sympathetic Blood pressure, heart rate, bladder control FLC SY Ex. Tricyclics |
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Serotonin
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RN - Frontal: Emotional
RN - Basal Ganglia: Motor Control RN - Limbic: Anxiety, fight/flight RN - Hypo: Motivation, Basic Drives RN - RAS: Sleep Sympathetic: Sexual functioning FBG LHRASSy SSRI's |
