Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
Xanthines act in the CNS to block which type of receptors:
A. Muscarininc B. Adrenergic C. Adenosine D. 5-HT |
C. Adenosine
|
|
|
What is the effect of xanthines on the kidneys?
|
Xanthines induce diuresis by increasing glomerular filtration and inhibiting reabsorption of Na+
|
|
|
Are adenosine receptors inhibitory or stimulatory?
|
Inhibitory
|
|
|
Which has more stimulation, caffeine or theophylline?
|
Trick question! They are about the same
|
|
|
Name 3 xanthine derivatives:
|
Caffeine, theophylline, theobromine
|
|
|
Which xanthine derivative is used in asthma prophylaxis (this is a review question from PB&T)
|
Thophylline
|
|
|
Which two drugs are used in conjunction to treat migraine attacks?
|
Ergotamine and Caffeine
|
|
|
How does caffeine help in the treatment of migraines?
|
Caffeine causes constriction of the cerebral vasculature and decreases the discomfort of the attack produced by vasodilatation
|
|
|
What is the most common ingredient in stay awake pills and diet pills?
|
Caffeine
|
|
|
In terms of sensitivity to amphetamines, which monoamine is the most sensitive? Which is the least sensitive?
|
NE is the most sensitive, 5-HT is the least sensitive.
|
|
|
What are the major side effects of amphetamines?
|
Restlessness, insomnia, decreased fatigue, decreased appetite, and incr. blood pressure
|
|
|
Overall, what is the clinical use of amphetamines as appetite suppressants?
|
Limited since tolerance develops in a few weeks
|
|
|
What is phenylpropanolamine?
|
An OTC amphetamine with minimal CNS effects used to suppress appetite and enhance satiety.
Stimulates 5-HT2C receptors. |
|
|
What is sibutramine? How does it work?
|
An amphetamine that blocks the reuptake of NE and 5-HT. Used in appetite suppression.
|
|
|
Which drug is similar to dl-amphetamine, weakly crosses the BBB and is a nasal decongestant?
|
Ephedrine
|
|
|
(T/F) Amphetamines are useful in the treatment of narcolepsy
|
True
|
|
|
What is Modafinil (Provigil)?
|
A newer amphetamine used to treat narcolepsy. It produces less edginess than other amphetamines.
|
|
|
In what sense is methylphenidate (Ritalin) a milder CNS stimulant than amphetamine?
|
in the sense that stimulation produced before convulsant doses are reached is less than with amphetamine.
|
|
|
Which has more abuse potential, methylphenidate or amphetamine?
|
Amphetamine probably has a little more abuse potential
|
|
|
Which substance produces more pronounced cardiovascular side effects - methylphenidate or amphetamine?
|
Amphetamine
|
|
|
How is atomoxetine (Strattera) different than the traditional stimulants?
|
It is a NE transporter inhibitor.
Also it does not have abuse potential and may not exacerbate tics as much. |
