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24 Cards in this Set

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A. BIOGENIC AMINES
Dopamine
Norepinephrine
Serotonin
Acetylcholine
1. Dopamine
Parkinson's
mood disorders
conditioned fear response
reward nature of drug abuse
schizophrenia + other psych. disorders
2. Norepinephrine
mood
anxiety
arousal
learning
memory
What agent converts dopamine to norepinephrine?

Where are the noradrenergic neurons located that synthesize dopamine
beta-hydroxylase

locus ceruleus
3. Serotonin
mood
sleep
pain sensitivity
appetite
sexuality
impulse control
What agent converts TRYPTOPHAN to SEROTONIN?

Where are the cell bodies located?
tryptophan hydroxylase

dorsal raphe nucleus
Inc. Serotonin =
___ sex desire
___ sleep desire
___ mood

Excess leads to ____
decrease
increase
increase

___ leads to psychosis
Dec. Serotonin =
___ depression
___ OCD
___ Dhronic pain syndromes
___ sleep disorders
___ anxiety disorders
all increase
4. Acetylcholine
used mainly at neuromuscular junctions
Alzheimer's Disease results when:

cholinergic neurons ___
or
choline acetyltransferase ___
are lost
or
production slows
You can delay the progression of Alzheimer's by blocking the action of ___
AChE
Acetylcholinesterase
Histamine availability is altered by _________ and responsible for what side effects?
psychoactive agents

sedation, and increased appetite
a. Dry mouth
b. Blurred Vision
c. Urinary Hesitancy
d. Consipation

Side-Effects of ___
Anticholinergic Side-Effects
B. AMINO ACID NEUROTRANSMITTERS

exs:
GABA
Glycine
Glutamate
GABA

associated with:
inhibitory or excitatory?
anxiety
inhibitory
2. Glutamate

associated with:
inhibitory or excitatory?
epilepsy, neurodegenerative disease, memory formation, cell death, Schizophrenia

excitatory
The major glutamate receptor is NMDA (n-methyl-D-aspartate).

Drugs that block NMDA cause ___
psychosis

is caused by what blocked receptor ___ (ligand ___)
C. NEUROPEPTIDES

exs:
Endogenous Opoids
Enkephalins
Endorphins
decreased pain and anxiety
role in mood and addiction
aa. CCK and Neurotensin
Schizophrenia
bb. Somatostatin
Substance P
Vasopressin
Oxytocin
VIP
Mood disorders
cc. Somatostatin
Substance P
Huntington's disease
dd. Somatostatin
VIP
Alzheimers
ee. Substance P
CCK
anxiety disorders
ff. Substance P
pain and aggression