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24 Cards in this Set
- Front
- Back
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A. BIOGENIC AMINES
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Dopamine
Norepinephrine Serotonin Acetylcholine |
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1. Dopamine
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Parkinson's
mood disorders conditioned fear response reward nature of drug abuse schizophrenia + other psych. disorders |
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2. Norepinephrine
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mood
anxiety arousal learning memory |
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What agent converts dopamine to norepinephrine?
Where are the noradrenergic neurons located that synthesize dopamine |
beta-hydroxylase
locus ceruleus |
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3. Serotonin
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mood
sleep pain sensitivity appetite sexuality impulse control |
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What agent converts TRYPTOPHAN to SEROTONIN?
Where are the cell bodies located? |
tryptophan hydroxylase
dorsal raphe nucleus |
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Inc. Serotonin =
___ sex desire ___ sleep desire ___ mood Excess leads to ____ |
decrease
increase increase ___ leads to psychosis |
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Dec. Serotonin =
___ depression ___ OCD ___ Dhronic pain syndromes ___ sleep disorders ___ anxiety disorders |
all increase
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4. Acetylcholine
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used mainly at neuromuscular junctions
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Alzheimer's Disease results when:
cholinergic neurons ___ or choline acetyltransferase ___ |
are lost
or production slows |
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You can delay the progression of Alzheimer's by blocking the action of ___
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AChE
Acetylcholinesterase |
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Histamine availability is altered by _________ and responsible for what side effects?
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psychoactive agents
sedation, and increased appetite |
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a. Dry mouth
b. Blurred Vision c. Urinary Hesitancy d. Consipation Side-Effects of ___ |
Anticholinergic Side-Effects
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B. AMINO ACID NEUROTRANSMITTERS
exs: |
GABA
Glycine Glutamate |
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GABA
associated with: inhibitory or excitatory? |
anxiety
inhibitory |
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2. Glutamate
associated with: inhibitory or excitatory? |
epilepsy, neurodegenerative disease, memory formation, cell death, Schizophrenia
excitatory |
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The major glutamate receptor is NMDA (n-methyl-D-aspartate).
Drugs that block NMDA cause ___ |
psychosis
is caused by what blocked receptor ___ (ligand ___) |
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C. NEUROPEPTIDES
exs: |
Endogenous Opoids
Enkephalins Endorphins decreased pain and anxiety role in mood and addiction |
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aa. CCK and Neurotensin
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Schizophrenia
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bb. Somatostatin
Substance P Vasopressin Oxytocin VIP |
Mood disorders
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cc. Somatostatin
Substance P |
Huntington's disease
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dd. Somatostatin
VIP |
Alzheimers
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ee. Substance P
CCK |
anxiety disorders
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ff. Substance P
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pain and aggression
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