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18 Cards in this Set
- Front
- Back
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Bupropion (Wellbutrin)?
- Mechanism? - Clinical Use? - Toxicity? In bulimics? No what? |
M - increased NE & dopamine
C - atypical antidepressant & smoking cessation T - stimulant, headache, seizures in bulimics, NO sexual side effects |
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Mitratzapine?
- Mechanism? - Clinical Use? - Toxicity? |
M - alpha 2 antagonist (increases NE & serotonin release), and 5-HT3 & 5-HT2 receptor antaogonist
C - Atypical Antidepressant T - sedation, increased appetite, weight gain, dry mouth |
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Maprotiline?
- Mechanism? - Clinical Use? - Toxicity? |
M - blocks NE reuptake
C - Atypical Antidepressant T - sedation, orthostatic hypotension |
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Trazodone?
- Mechanism? - Clinical Use? - Toxicity? - Nickname? |
M - inhibits serotonin reuptake
C - Atypical Antidepressant & Insomnia T - sedation, nausea, priaprism, postural hypotension trazoBONE (male side effects) |
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Tranycypromine, Isocarboxazid, Phenelzine, Selegiline
- Which is selective? - Clinical use? - Important drug interactions? - Toxicity? |
MAO Inhibitors
Selegiline -selective MAO-B inhibitor others - non selective MAO inhibition - increased amine neurotransmitters C - Atypical Antidepression, Anxiety, Hypochondriasis T - Hypertensive crisis with Tyramine ingestion (wine, cheese, beer) and B agonists, CNS stimulation Serotonin syndrome with other SSRI's or Meperidine |
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Venlafaxine, Duloxetine?
- Mechanism? - Clinical Use? - Toxicity? |
Selective NE Reuptake inhibitors
M - inhibits serotonin and NE reuptake - Duloxetine has more effect on NE C - Depression, Generalized Anxiety Disorder (Venlafaxine), Diabetic Peripheral Neuropathy (Duloxetine) T - increased MBP, stimulant side effects, sedation, nausea |
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Fluoxetine, Paroxetine, Sertaline, Citalopram?
- Mechanism? - Clinical Use? - Toxicity? - What is Sertonin Syndrome? Treat how? |
SSRI's
M - selective serotonin reuptake inhibitors C - Depression, OCD, bulimia, social phobias T - fewer than TCAs - GI distress & sexual function Serotonin Syndrome with other antidepressants (hyperthermia, muscle rigidity, diarrhea, flushing, CV collapse) - TREAT WITH CYPROHEPTADINE (5-HT2 receptor antagonist) |
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Imipramine, Amitriptyline, Desipramine, Nortriptyline, Clomipramine, Doxepin, Amoxapine?
- Mechanism? - Clinical Use? - Toxicity? Mild? Severe? |
TCAs
M - blocks reupatke of NE and serotonin C - Major Depression, Bed Wetting (Imipramine), OCD (Clomipramine), Fibromyalgia T - sedation, alpha-blocking effects, anticholingeric effects (Amitriptyline has strongest) Extreme - Tri-C - Convulsions, Coma, Cardiotoxicity (arrhythmia - TREAT WITH NaHCO3)), respiratory depression, hyperpyrexia, confusion and hallucinations (anticholingeric) * Desipramine is least sedating but has lowest seizure threshold |
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Buspirone?
- Mechanism? - Clinical Use? - Toxicity? |
M - stimulates 5-HT1A receptors
C - Generalized Anxiety Disorder T - NONE - no sedation, addiction, tolerance, NO interaction with alcohol |
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Lithium?
- Mechanism? - Clinical Use? Watch closely why? - Toxicity? |
M - not established
C - mood stabilizer for Bipolar Disease, blocks relapse and manic events T - tremor, sedation, edema, heart block, hypothyroidism, polyuria (ADH antagonist so causes Nephrogenic Diabetes Insipidus), teratogenesis NARROW THERAPUETIC WINDOW LMNOP - Lithium Side Effects are Movement (tremor), Nephrogenic Diabetes Insipidus, hypOthyroidism, Pregnancy problems |
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Olanzapine, Clozapine, Quetiapine, Risperidone, Apripiprazole, Ziprasidone?
- Mechanism? - Clinical Use? - Toxicity? Olanzapine & Clozapine specifically? |
Atypical Antipsychotics
M - Blocks 5-HT2, alpha, H1, and dopamine receptors C - schizophrenia (positive and negative sx), Olanzapine also for OCD, Anxiety Disorder, Depression, Mania, Tourette's Syndrome T - fewer extrapyrmidal and anticholinergic side effects than traditional antipsychotics, Olanzipine/Clozapine can cause weight gain and metabolic syndrome, Clozapine can cause agranulocytosis (WBC monitored weekly) |
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Haloperidol, Trifluoperazine, Fluphenazine, Thioridazine, Chlorpromazine?
- Which are low potency? high potency? - Mechanism? - Clinical Use? |
Neuroleptics (Typical Antipsychotics)
* High Potency - Haloperidol, Trifluoperazine, Fluphenazine - neurological side effects * Low Potency - Thioridazine, Chlorpromazine - non-neurological side effects M - block D2 receptors (increase cAMPi) C - Schizophrenia (positive sx), psychosis, acute mania, Tourette's Syndrome |
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Typical Antipsychotics?
- Soluble where? - Endocrine Side effects? - Side effects per receptor blocked? - EPS side effects? time line? - Syndrome? - Specific side effects of Chlorpromazine? Thioridazine? |
* Soluble in fat so very slowly removed from the body
- Endocrine - Dopamine receptor antagonist - hyperprolactinemia, galactorrhea - dry mouth, constipation (antimuscurinic), hypotension (alpha receptor), sedation (histamine receptor) - Extrapyrimidal Sx - * 4 hours - acute dystonia (muscle spasm, stiffness, oculogyric crisis) * 4 days - akinesia (no movement) * 4 weeks - akathisia (restlessness) * 4 months - Tardive Dyskinesia * Neuroleptic Malignant Syndrome Chlorpromazine - Corneal deposits Thioridazine - reTinal despoits (retina pigmentosa) |
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What is Neuroleptic Malignant Syndrome? Treat how?
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NMS - rigidity, myoglobinuria, autonomic instability, hyperpyrexia TREAT - Dantrolene, Dopamine Agonists (Bromocriptine)
FEVER - Fever, Encephalopathy, Vitals Unstable, Elevated Enzymes, Rigidity of Muscles |
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What is Tardive Dyskinesia?
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sterotypical oral-facial movements in long term antipsychotic use (often irreversible)
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Methylphenidate?
- Mechanism? - Clinical Use? |
M - increases presynaptic NE vesicular release (like amphetamines)
C - ADHD |
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Treat the following conditions how?
* Social Phobia? * Tourette's Syndrome? * Schizophrenia? * PTSD? * Panic Disorder? * OCD? * Depression with Insomnia? * Depression? |
SP - SSRI
TS - Haloperidol S - Antipsychotics PTSD - SSRI PD - SSRI, TCA, Benzos OCD - SSRI, Clomipramine D with Insomnia - Mirtazapine D - SSRI, SNRI, TCA |
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Treat the following conditions how?
* Bipolar? * Atypical Depression? * ADHD? * Anxiety? * Anorexia/Bulimia? * Alcohol Withdrawal? |
BP - Lithium, Valproic Acid, Carbamazepine
AD - MAOi, SSRI ADHD - Methylphenidate (Ritalin), Amphetamines (Dexedrine) Anxiety - Benzos, Buspirone, SSRI A/B - SSRI Alochol - Benzos |
