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65 Cards in this Set
- Front
- Back
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List Five Seratonin Reuptake Inhibitors
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Prozac (Fluoxetine)
Zoloft (Sertraline) Celexa/Lexapro (Citalopram) Paxil (Paroxitine) Luvox (fLUVOXamine) |
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What is Fluoxetine?
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Prozac
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What is Sertraline?
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Zoloft
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What is Citalopram?
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Celexa/Lexapro
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What is Paroxitine?
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Paxil
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What is fluvoxamine?
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Luvox
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Prozac (fluoxetine)
Activating, neutral or sedating? Half life? D/c risk? Wt gain? |
Activating
Half life is 2 weeks No discontinuation risks Initial wt loss, neutral long term P450 Mod Inhibitor 2D6 |
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Zoloft (sertraline)
Activating, neutral or sedating? Half life? D/c risk? Wt gain? |
Neutral
Half life 2-3 days D/c risk 2% P450 Low Wt Neutral |
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Celexa/Lexapro (citalopram)
Activating, neutral or sedating? Half life? D/c risk? Wt gain? |
Minimally sedating
Halve life 2-3 days D/c risk 2% P450 very low Wt gain minimal |
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Paxil (paroxitine)
Activating, neutral or sedating? Half life? D/c risk? Wt gain? |
Mildly sedating
Half live 1 day D/C Risk 20% !!! P450 Mod 2D6 Wt neutral, Long term gain |
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Luvox (Fluvoxamine)
Activating, neutral or sedating? Half life? D/c risk? Wt gain? |
Moderately Sedating
Half life 15 hours D/C risk 14% P450 34A Effective for OCD, but not used for it. Not FDA approved |
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How many half lives does it take for a medication to "wash out"?
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4-5 half lives
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Name that antidepressant...
5HT, NE, DA SE: Increased Diastolic BP |
Effexor XR
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What is the other name for Effexor XR?
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Venlafaxine
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Name that antidepresant...
Very activating...don't use if anxiety is an issue. No sexual side effects Unlikely to induce mania Also used for adult ADHD and smoking cessation. Don't use if history of seizure d/o or eating d/o |
Wellbutrin
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What is the other name for Wellbutrin?
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Buproprion
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Name that antidepressant...
NE, 5HT Common SE: Sedtation and Wt gain Does not effect REM sleep. Great for depressed cachextic elderly. Unlikely to induce mania Very low sexual side effects |
Remeron
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What is the other name for Remeron?
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Mirtazapine
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Name that antidepressant...
VERY sedating Used as an anxiolytic @ subtherapeutic levels Vivid dreams, priapism, orthostatic hypotension 5HT |
Trazodone
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What is the other name for Trazodone?
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Desyrel
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Name that antidepressant...
VERY potent Good for chronic pain Increased LFT's Decreased sodium Anticholingergic 2D6 inhibitor Half life 12 hours BAD discontinuation syndrome |
Cymbalta
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What is the other name for cymbalta?
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Duloxatine
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What type of drugs are Haldol, Prolixin, Thorazin and Mellaril?
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TYPICAL antipsychotics
ie only for positive symptoms (hallucinations, illusions and delusions) |
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What are the other names for the following?
Haldol Prolixin Thoraine Mellaril |
Haloperidol
Fluphenezine Chlorapromazine Thioridizine |
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Haldol vs Thorazine..which is high potency?
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Haldol - high potency
Thorazine - low potency |
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Haldol and Prolixin are associated with what two side effects?
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TD and EPS
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What are the side effects associated with Thorazine and Mellaril?
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Sedating and anticholinergic
Also: At high levels, Mellaril can cause retinosa pigmentosa |
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Atypicals work for positive or negative symptoms?
Do they have TD? EPS? Prolactin elevation? |
Atypicals work for positive AND negative symptoms.
Low TD Low EPS Low Prolactin Elevation |
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List 7 Atypical Antipsychotics
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Chlozaril
Risperdal Zyprexa Seroquel Geodon Abilify Invega |
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Name that atypical antipsychotic...
Can cause agranulocytosis, sz d/o and sedation. SE Drooling, anticholinergic But NO TD or EPS |
Chlozaril
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What is the other name for Chlozaril?
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Chlozapine
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Name that atypical antipsychotic...
An atypical that elevates prolactin Is the least atypical in its class because it can cause EPS and TD |
Risperdal
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What is the other name for risperdal?
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Risperdone
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Name that atypical antipsychotic...
SE include: Wt Gain, DM, Sedation, anticholinergic It's a very potent mood stabilizer in bipolar disorder. |
Zyprexa
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What is the other name for Zyprexa?
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Olanzapine
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Name that atypical antipsychotic...
It is less sedating, has less wt gain associated, and does not have any of the typical antipsychotic side effects. |
Seroquel
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What is the other name for Seroquel?
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Quetiapine
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Name that atypical antipsychotic...
SE include QT prolongation No wt gain Antidepressant effects Low EPS and TD |
Geodon
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What is the other name for Geodon?
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Ziprasidone
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Name that atypical...
No EPS, TE or wt gain. Decent mood stabilizer Akathesia |
Abilify
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What is the other name for Abilify?
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Aripiprazole
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Name that atypical...
Similar to Risperdal Short acting |
Invega
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What is the long acting version of Invega?
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Sustenna
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What are the two long acting atypical antipsychotics?
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Sustenna (up to 4 wks)
Risperdal (injection 24 hours) Typical Haldol can last up to two weeks |
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What are the four mood stabilizers?
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Depakote
Lithium Tegratol Lamictal |
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What is the other name for depakote?
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Divalproex sodium
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What is the other name for Tegratol?
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Carbamazepine
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What is the other name for Lamictal?
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Lamotrigine
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Name that mood stabilizer...
SE include thrombocytopenia, increased LFT's, pancreatitis, wt gain, alopecia |
Depakote
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What mood stabilizers (3) can cause neural tube defects in a fetus?
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Depakote, Tegratol and Lamictal
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What drug can cause Epstein's Anomaly in a fetus?
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Lithium
It can be used in 2nd trimester safely, but not 1st or 3rd |
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Name that mood stabilizer...
SE include hypothyroidism, Acne, wt gain, it is lethal to OD on, and at the very least will need dialysis. Hydration is key. |
Lithium
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What is the rule of 8's and 12's?
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Therapeutic levels of:
Depakote 80 - 120 Lithium 0.8 - 1.2 Tegratol 8 - 12 |
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Name that mood stabilizer...
It increases the metabolism of itself and other drugs. Serious SE is Steven Johnson Syndrome |
Tegratol
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Name that mood stabilizer...
SE include Steven Johnson Syndrome This drug is a good choice if the problem is more so due to depression and less so to mania. |
Lamictal
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What is first line for Bipolar disorder?
What about in the acute setting? |
Lithium is gold standard
Haldol should be used in acute setting because Lithium will not begin to help for up to 4-6 days. |
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MAOI's should be used with caution because of their side effects and interactions. They are particularly useful in patients characterized by
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atypical depression, w/ symptoms such as hypersomnia, increased appetite and personality difficulties such as rejection sensitivity.
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In bipolar and unipolar mood disorders, MRI has shown an increased number of focal signal hypersensitivities in _____ matter.
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white
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What are some of the ideas of the biology behind panic attacks?
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INcreased catecholamine levels in the cns
An abnormality in the locus coerules CO2 hyper sensitivity Disturbance of lactate metabolism Abnormalities of the GABA (gamma aminobutyric acid) system |
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What class of medications is most useful in treating panic attacks?
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SSRI's
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What is the best class of drugs to use for specific phobia's that are via dopaminergic activity?
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MAOI's
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Drugs used to treat ________ _________ include fluoxetine, paroxetine, sertraling, and venlafaxine.
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social phobia's
TCA's are probably less effective |
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What are some of the treatments for OCD?
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1. Behavior Therapy
2. SSRI's 3. Clopramine (TCA) 4. Venlafaxine (Effexor) an SNRI |
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Class of drugs used to treat PTSD?
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SSRI's
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What two drugs have been shown to reduce anger, threatening behavior and assaultiveness among prisoners? (ie antisocials)
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Lithium and phenytoin
Other drugs, including the second gen antipsychotics, carbamazepine and valproate have been used with some success. |
