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62 Cards in this Set
- Front
- Back
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MOA of SSRI
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blocks reutake of serotonin
- ine (fluoxetine, sertraline, paroxetine, citalopram) |
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Which drug is a SSRI but its name looks like benzo?
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Citralopram
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Side effects of SSRI
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flushing
sexual dysfunction Serotonin Syndrome= w/ MAOI |
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Tx for serotonin syndrome
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cyproheptadine (5 HT2 receptor antagonist)
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How many weeks takes to see the antidepressant effect?
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2-3 weeks
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MOA of TCAs
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1- blocks SER and NORE
2- alpha blocker 3- antimuscarinic -amine, -tyline |
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Side effects of TCAs
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1- euphoria
2- HTN 3- hot, dry mad, red Tri C: Convulsions, Coma, Cardiotoxicity |
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Tx for CV toxicity of TCAs
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NaHCO3
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MOA of MAOI
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MAO A- blocks dopa
MAO B- blocks ser, nore, epi (Ex: Phenelzine, Tranyleypromine, selegline) |
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Side effects of MAOI
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Hypertensive crisis with tyraminase ingestion and Beta agonist
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Containdication for MAOI
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Concurrent use of SSRI or meperidine
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MOA of Tradozone
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Blocks serotonin reuptake
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SE of tradozone
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priapism
sedation nausea postural hypotn |
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MOA of Nefazadone
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blocks ser
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SE of Nefazadone
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Dizziness
sedation HTN flushing |
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What is the antideprasant that causes no sexual side effects?
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Bupropion
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MOA of Bupropion
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Blocks DOPA, NORE, nicotinic reuptake
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Smoking cessation
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Bupropion
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Side effects of bupropion
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Seizures
euphoria HTN tachycardia |
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name two SNRI
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venlafaxine
duloxetine |
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MOA of SNRI
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inhibits ser and NORE reuptake
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Clinical use of venlafaxine
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generalized anxiety disorder
depresion |
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clinical use of duloxetine
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diabetic peripheral neuropathy
depresion |
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MOA of Mirtrazapine
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selective alpha2 blocker--> release SER, NORE
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Side effect of Mirtrazapine
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weight gain
dry mouth sedation |
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Moa of Buspirone
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stimulates 5 HT1-A receptors
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clinical use of Buspirone
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general anxiety disorder
doesn't interact w alcohol |
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Na channel blockers for bipolars
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valproic acid
carbamazepine phenytoin lamotrigmine |
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SE of lamotrignime
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Skin rash
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Ca channel blocker for epilepsy
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Ethosuxamide
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MOA of Ethosuxamide
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blocks T-type Ca channel in the thalamus
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Tx for trigeminal neuralgia
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carbamazepine
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Which Na channel blocker causes Gout?
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Valproic acid
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MOA of antipsicotics(typicals)
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Block D2 receptors
Haloperidol, -zine |
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SE of typicals antipsycotics
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extrapyramidal
- dystonia -akinesia -dyskinesia galactorrea neuroleptic malignant syndrome |
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Tx for neurolectic malignant syndorme
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dantrolene
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SE of chlopromazine
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Corneal deposits
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SE of thioridazine
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reTinal deposits
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MOA of Atypical antipsycotics
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block 5 HT2, alpha, H1 and DOPA receptors
Risperidone, - zapine |
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SE of clozapine
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Agranulocitosis
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MOA of Lithium
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possible inhibition of phosphoinositol cascade
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Clinical use of lithium
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bipolar
SIADH |
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SE of lithium
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hypothyroidism
nephrogenic diabetes insipidus teratogenic tremor heart block |
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MOA of methylpenidate
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incr presynaptic NE vesicular release
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MOA of barbiturates
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incr duration of CL channel--> incr GABA a
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SE of barbiturates
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dependance
respiratory and cv depression inducer of CYT P450 |
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Contraindication for barbiturates
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porphyrias
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MOA of benzodiazepines
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incr frequency of CL channel opening--> facilitates GABA a action
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Clinical use of benzodiazepines
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anxiety
epilepsy alcohol withdrawal night terror sleepwalking general anesthesic |
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SE of benzodiazepines
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CNS depression with alcohol
respiratory depresion |
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tx for toxicity of benzodiazepines
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flumazenil
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Short acting benzos
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TOM Thumb
triazolam oxazepam midazolam alprazolam |
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medium benzos
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lorazepam
estazolam temezepam |
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long benzo's
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diazepam
flurazepam clorazepate clordiazepoxide |
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barbiturate that when is activated becomes phenobarbital
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primidone
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clinical use for midazolam
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endoscopy
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clinical use for lorazepan
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alcohol withdrawal
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Tx for social phobia
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SSRI
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What is tranylcypromine?
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MAOI
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Serotonin Syndrome
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fushing, diarrhea, sweating, muscle rigidity
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Tx for acute dystonia
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anticholinergics= benztropine
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What is modafinil? and its clinical use?
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Psychostimulant that is used for excesive daytime sleepiness
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