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55 Cards in this Set
- Front
- Back
Potential side effect from dopamine blockade by antipsychotics?
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Increases prolactin concentration, which may lead to galactorrhea, impotence, menstrual dysfunction, and decreased libido.
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Unique side effect of thioridazine.
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retinal pigment deposits
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Unique side effect of clozapine.
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agranulocytosis
(monitor CBCs weekly) |
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Unique side effect of chlorpromazine.
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jaundice and photosensitivity
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Signs and symptoms of mania.
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DIG FAST:
Distractability, Insomnia, Grandiosity, Flight of ideas, Activities agitation, Sexual indiscretion/Shopping sprees, Talkativeness |
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Classic presentation of bipolar disorder.
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A history of mania alternating with depression.
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Age of onset for bipolar disorder
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Between 16 and 30 years of age
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First line of treatment for bipolar disorder
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Lithium and Valproic acid
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Second line of treatment for bipolar disorder
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Carbamazepine, olanzapine, and gabapentin
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Side effects of lithium
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Think: Brain, Thyroid, Kidneys
Brain: tremor Thyroid: hypothyroidism, weight gain Kidneys: nephrogenic diabetes insipidus, thirst |
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Organ dysfunction with valproic acid use
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Liver disfunction
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SE of carbamazepine
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bone marrow depression
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Bipolar I vs Bipolar II
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Bipolar I: mania + MDE
Bipolar II: hypomania + MDE |
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Mania vs hypomania
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Hypomania = mild mania wihtout psychosis that does not cause occupational dysfunction
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Cyclothymia
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Hypomania + moderate depression
for > 2 years |
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Bipolar epidemiology:
Prevalence, gender ratio, age of onset, suicide rate |
prevalence = 1%
male:female ratio = 1:1 age of onset = 20's suicide rate = 10-15% |
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Signs and symptoms of typical Depression
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SIG E CAPS
Sleep (decr), Interest (decr), Guilt, Energy (decr), Concentration (decr), Appetite (decr), Psychomotor agitation, Suicidal ideation (2/3 of patients) |
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Pyschiatric disorder that has the greatest risk of suicide
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Depression
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Sleep cycle disturbance in depression
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Decreased REM sleep
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Feature that worsens the prognosis of depression
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Psychotic features: typically mood congruent delusions/hallucinations
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S/S of atypical depresion
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Weight gain, hypersomnia, rejection sensitivity
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Treatment of atypical depression
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MAOI: Phenelzine, Tranylcypromine
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Dysthymia
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Depression for > 2 years
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Adjustment disorder
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Depression that occurs within 3 months of a stressor (job loss, move) and resolves by 6 months
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Gender with greater incidence of depression
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Female
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Risk of antidepressant use in bipolar patients
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Antidepressants can trigger mania or hypomania in bipolar patients
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First line drug treatment of depression
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SSRI: Fluoxetine, Sertraline, Paroxetine
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MOA and SE of TCA's
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MOA: prevents reuptake of NE and serotonin
SE: Tri-A's Anticholinergic Antimuscarinic (orthostatic hypotension) Arrthymia (cardiac, fatal) |
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Second line drug treatment of depression
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TCA: Nortriptyline, Amitriptyline
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MOA and SE of SSRI's
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MOA: prevent reuptake of serotonin
SE: sexual dysfunction, insomnia, anorexia |
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Dietary caution with use of MAOI
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Foods containing tyramine (red wine and aged cheese) may cause hypertensive crisis.
Same can happen with MAOI and SSRI or meperidine. |
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Unique SE of trazodone
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Priapism: painful, sustained erection without sexual arousal or desire
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Unique SE of bupropion
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Decreased seizure threshold
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Atypical antidepressants
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Bupropion, Trazodone
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Serotonin syndrome
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Fever, myoclonus, mental status change, cardiovascular collapse
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Most effective treatment of depression
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Electroconvulsive therapy; use if immediate treatment is necessary.
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Grief/bereavement
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Depression developing after the loss of a loved one, but limited to one year only. S/S for > 1 yr = depression.
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Can grief include illusion or hallucinations?
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Yes, but a normal grieving person knows that they are only illusions or hallucinations, whereas a depressed person believes the illusions or hallucinations are real.
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Signs that grief is actually depression
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Feelings of worthlessness, psychomotor retardation, and suicidal ideations.
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Treatment of grief/bereavement
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Support, pscythotherapy. No drugs needed for grief because it is self-limiting.
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Cluster A PDs
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Paranoid
Schizoid Schizotypal |
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Cluster B PDs
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Borderline
Antisocial Histrionic Narcissistic |
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Cluster C PDs
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OCPD
Avoidant Dependent |
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Paranoid PD
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Axis II
distrustful/suspicious of other people There are no hallucinations/delusions as seen in paranoid schizophrenia. |
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Schizoid PD
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Axis II
isolated, "loner" Patient is content with being alone. |
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Schizotypal PD
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Axis II
Odd behavior, perception, appearance Magical thinking, ideas of reference |
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Borderline PD
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Axis II
Volatile, unstable mood, impulsive Pts exhibit "splitting": people are either all good or all bad |
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Antisocial PD
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Axis II
Violate rights of others, social norms, and laws. Cruel to people and animals. Strong association with alcoholism and drug abuse as well as somatization disorder. Must show s/s by age 15, and cannot be diagnosed until age 18. Younger than 18 = conduct d/o. |
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Histrionic PD
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Axis II
Attention-seeking, overly-dramatic, and inappropriately seductive |
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Narcissistic PD
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Axis II
Egocentric and lacking empathy; grandiose Pts react with rage when critisized. |
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OCPD
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Axis II
Preoccupied with perfectionism, order, and control anal-retentive, stubborn very inefficient |
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Avoidant PD
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Axis II
Socially inhibited, rejection sensitive, fear of being disliked or ridiculed Pts are loners, but desire to have friends. |
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Dependent PD
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Axis II
Submissive, clingy, highly dependent of others Cannot make decisions alone e.g. a wife who stays with her abusive husband |
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Axis II d/o that most close resembles schizophrenia
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Schizotypal PD
Schizotypal pts may become psychotic. |
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Axis II d/o that has suicidal ideations
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Borderline PD
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