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77 Cards in this Set
- Front
- Back
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these drugs are used in the tx of all subtypes of depression, including depressed phase of bipolar, psychotic depression, atypical depression, seasonal depression, prevention of recurrent depressive episodes, dysthymic d/o
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antidepressiants
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panic d/o has responded to
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SSRI, MAOIs, TCI and high potency BZ (alprozolam [xanax] & clonazepam [klonipin])
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OCD responds to
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Anafranil (clomipramine) -seratonin specific tricyclic
SSRI at high doses - fluoxetine 80mg, fluvoxetine 300mg |
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symptoms of OCD may take how many weeks before they respond
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12 wks
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bulemia has been shown to respond to
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ssris, tcas, maoi
(ssri are 1st line) |
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tca moa
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snri
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moai moa
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reversibly inhibits mao increasing d2,ne,5ht
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ssris
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floxetine (prozac)
sertraline (zoloft) paroxetine (paxil) fluvoxamine (luvox) citalopram (celexa) escitalopram (lexapro) |
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dose of fluoxetine (prozac)
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20-80
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dose of sertraline (zoloft)
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50-300
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dosse of paroxetine (paxil)
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20-50
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dose of fluvoxamine (luvox)
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50-300
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dose of citalopram (celexa)
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20-60
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dose of escitalopram (lexapro)
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10-30
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SNRIs
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venlafaxine (effexor)
Duloxetine (cymbalta) |
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dose of venlafaxine (effexor)
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75-450
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dose of duloxetine (cymbalta)
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40-120
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Seratonin receptor agonists and antagonists
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trazodone (desyrel)
nefazodone |
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dosage of SR ant/ag
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200-600
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NDRI
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Bupropion (wellbutrin)
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dose of wellbutrin
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200-450
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TCAs
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Nortriptyline (Pamelor
Imipramine (Tofranil) Desipramine (Norpramin) Clomipramine (Anafranil) |
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dosage of TCA
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150-300
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MAOIs
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Tranylcyprominde (Parnate)
Phenelzine (nardil) Isocarboxazid (Marplan) |
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alpha 2 agonists
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Mirtazapine (Remeron)
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Mirtazapine (Remeron)dosage
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15-60
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antidepressants for OCD
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high dose SSRI and anafranil (clomipramine)
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AD for neuropathic pain
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tricyclic drugs and SNRI
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AD for insomnia
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trazodone, amitryptyline
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AD for enuresis
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imipramine
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AD for ADHD
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desipramine (norpramin), buproprion (welbutrin)
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higher rates of depression remission with
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venlafaxine (effexor)
and trycyclics |
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TCAs with least sedative, anticholinergic, and orthostatic hypotensive effects
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nortriptyline (pamelor)
Despipramine (Norpramin) |
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worry about cardiac effects with
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tca
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worry about siezures with
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tcas
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these drugs require serum level measurements to determine dosing
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TCAs
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ssri+maoi=
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seratonin syndrome
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no tca with elderly because
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ortherstatic hypotension=falls
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no tca with people with this condition
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heart conditions
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hypertensive crisis
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MAOI
tx with IV phentolamine or nitroprusside |
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this MAO is stimulatory
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tranylcypromine (parnate)
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this MAO is sedating
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phenelzine (Nardil)
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this dnri has a risk of seizures
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buproprion (wellbutrin)
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this alpha 2 agonist modulates NE & 5ht. it is sedating and can cause weight gain. It has a low risk of sexual side effects.
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mirtazapine)
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all tricyclics are highly sedative except
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Protrypline (vivactyl)
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t or f tricyclics have low GI side effects
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t
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T or F tricyclics have high orthostatic se
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t
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t or f tricyclics have high anticholinergic effects
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t
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t or f tricyclics all have high incidence of sexual side effects
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t
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what are the tetracyclic ADs
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maprotiline (ludiomil)
amoxapine (ascendin) |
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dosages for tetracyclics
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25-400
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tetracyclics are sedative or agitating
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mildly sedative (less than tricyclics)
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what are the MAOI
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phenelzine (nardil)
Tranycypromine (Parnate) |
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MAOI have high risk of sexual SE t or f
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t
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MAOI have high risk of orthostatic htn t or f
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t
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MAOI have high risk of gi side effects
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f
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which MAO is sedative and which is agitatin
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phenelzine (nardil)-sedating
trancypromine (parnate)-agitating |
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do MAOIs have anticholenergic effects
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moderate
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are the SSRIs anti-cholenergic
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no
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do ssris have sexual side effects
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yes
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do the ssris cause orthostatic htn
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no
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do the ssris cause gi side effects
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yes
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is prozac sedating or agitationg
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agitating
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is zoloft sedating or agitating
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agitating (less than prozac however)
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is paxil sedating or agitating
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neither (perhaps sedating)
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is luvox sedating or or agitatin
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mildy sedating
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is celexa and lexipro sedating or agitating
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neither
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does trazedone have sexual side effects
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very little
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does trazadone have anticholenergic activity
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very little
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is trazedone sedative
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yes-very much
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does trazedone cause orthostatic htn
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yes very much
caution in older pts |
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does trazedone cause gi side effects
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moderately
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Nefazodone is very much like trazedone except for how
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les orthostasis
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welbutrin has few side effects except
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agitation and moderate GI SE
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effexor and cymbalta are very similar drugs in their side effect profile t or f
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t
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effexor and cymbalta are very similar to the SSRI and are mildly agitating t or f
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t
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mirtazepine is free from side effects except for this
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very sedating
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