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11 Cards in this Set
- Front
- Back
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methylphenidate
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primary use in adhd, improves rate of functional recovery and attention in acute rehab setting after TBI, improves arousal and speed of info processing. short half life, abuse potential, safe in medically ill pts
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dextroamphetamine
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used for adhd, also used to treat attention and memory improvement following tbi. similar to methylphenidate. might work when methylphenidate doesn't.
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bromocriptine
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improves executive fcn and motivation in the late injury period. dopamine agonist
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l-dopa/carbidopa
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may improve impaired motivation, hypoarousal, and inattention, and executive function after tbi
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amoxetine
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NE reupatke inhibitor, used in add, and some TBI related attentional defets
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duloxetine
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selective NE reuptake inhibitor, mainly used as an antidepressant but might enhave attentional defects after tbi
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donepezil, rivastigmine, galantamine
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alzheimer's meds, inhibit acetylcholinesterase
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memantine and amatadine
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NMDA receptor antagonists, DA agonists. both increase DA release, decrease presynaptic DA reupatke, enhance post synaptic DA receptor senstivity. amantadine showed improvement in TBI patients
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rivastigmine results
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improved some aspects of memory function in TBI patients
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cytidine 5' diphosphocoline (CDP choline)
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metabolized into cytidine and choline if taken po. one study showed reduction in post-concussional sx after mild to moderate tbi
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modafinil
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approved for treatment of daytime solnolence in pts with narcolepsy. may have role in post TBI fatigue and cognitive impairment. exact mechs not understood, might be orexin activation, GABA reduction, increase in glu release, increase in DA in nACC.
shown to be affective in ADD |
