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37 Cards in this Set

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Name the 4 Monoamines neurotransmitters.
1. Dopamine (DA)
2. Norepinephrine (NE) (noradrenaline)
3. Serotonin (5-HT)
4. Histamine
What are the 5 receptors of the Dopamine (DA) transmitter?
D1, D2, D3, D4, D5
What are the effects/functions of Dopamine (DA)?
1. Involved in fine muscle movement.
2. Involved in integrating of emotions and thoughts.
3. Involved in decision making.
4. Stimulates hypothalamus to release hormones (sex, thyroid, adrenal)
What mental illnesses are associated with decreased level of dopamines (DA)? (2)
1. Parkinson's disease
2. Depression
What mental illnesses are associated with increased level of dopamines (DA)? (2)
1. Schizophrenia
2. Mania
What are the 4 receptors of Norepinephrine (NE) (noradrenaline)?
1. alpha 1
2. alpha 2
3. beta 1
4. beta 2
What are the effects/functions of Norepinephrine (NE) (noradrenaline)? (2)
1. Level in brain affects mood.
2. Stimulates sympathetic branch of autonomic nervous system for "fight or flight" in response to stress.
What mental illness is associated with decreased level of Norepinephrine (NE) (noradrenaline)?
Depression
What mental illnesses are associated with a increase level of Norepinephrine (NE) (noradrenaline)? (3)
1. Mania
2. Anxiety states
3. Schizophrenia
What are the 4 receptors of Serotonin (5-HT)?
5-HT, 5-HT2, 5-HT3, 5-HT4
What are the effects/functions of Serotonin (5-HT)? (2)
1. Plays a role in sleep regulation, hunger, mood states, and pain perception.
2. Plays role in aggression and sexual behavior.
What mental illness is associated with a decrease level of Serotonin (5-HT)?
Depression
What mental illness is associated with a increase level of Serotonin (5-HT)?
Anxiety
What are the 2 receptors of Histamine?
H1, H2
What are the effects/functions of Histamine?
1. Involved in alertness
2. Involved in inflammatory response
3. Stimulates gastric secretion
What mental illness are associated with a decrease level of Histamine?
1. Depression
2. Sedation
3. Weight gain
What are the two amino acids transmitters?
1. Gama-aminobutyric acid (GABA)
2. Glutamate
What are the 2 receptors of Gama-aminobutyric acid (GABA)?
GABAa, GABAb
What are the effects/functions of Gama-aminobutyric acid (GABA)? (3)
1. Plays a role in inhibition; reduces agression, excitation, and anxiety.
2. May play a role in pain perception.
3. Has anticonvulsant and muscle-relaxing properties.
What mental illnesses are associated with a decrease level of Gama-aminobutyric acid (GABA)? (3)
1. Anxiety disorders
2. Schizophrenia
3. Huntington's disease
What are the 2 receptors of Glutamate?
1. NMDA
2. AMPA
What are the effects/functions of Glutamate?
1. Is excitatory
2. Plays role in learning and memory.
What mental illness is associated with a decrease level of (NMDA) Glutamate?
Psychomimetic state that resembles schizophrenia.
How is increased level of (AMPA) Glutamate associated with mental health?
Improvement of cognitive performance on behavior tasks.
What transmitter is classified as Cholinergic?
Acetylcholine (ACh)
What are the 2 receptors of Acetylcholine (ACh)
Nicotinic
Muscarinic (M1, M2, M3)
What are the effects/functions of Acetylcholine (ACh)? (4)
1. Plays a role in learning, memory.
2. Regulates mood: mania, sexual aggression
3. Affects sexual and aggressive behaviors
4. Stimulates parasympathetic nervous system.
What mental illnesses are associated with a decrease level of Acetylcholine (ACh)?
(3)
1. Alzheimer's disease
2. Huntington's Chorea
3. Parkingson's Disease
What mental illness is associated with a increase level of Acetylcholine (ACh)?
Depression
What are the 3 neuro peptides (Neuromodulators) transmitters?
1. Substance P (SP)
2. Somatostatin (SRIF)
3. Neurotensin (NT)
What are the effects/functions of Substance P (SP)? (3)
1. Centrally active SP antagonist has antidepressant and antianxiety effects in depression.
2. Promotes and reinforces memory.
3. Enhances sensitivity to pain receptors to activate
How is Substance P (SP) associated with mental health?
1. Involved in regualtion of mood and anxiety.
2. Role in pain management
What is the effect/function of Somatostatin (SRIF)?
Altered levels associated with cognitive disease.
What mental illnesses are associated with a decrease level of Somatostatin (SRIF)? (2)
1. Alzheimer's disease
2. Depression: Decrease levels of SRIF found in spinal fluid of some depressed clients.
What mental illness is associated with a increase level of Somatostatin (SRIF)?
Huntington's chorea
What is the effect/function of Neurotensin (NT)?
Endogenous antipsychotic-like properties.
What mental illness is associated with decrease Neurotensin (NT)?
Schizophrenic: decrease levels found in spinal fluid of schizophrenic clients.