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58 Cards in this Set

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SSRI's class ADR's
Sexual side effects
anorexia, weight loss, weight gain,
-bruxism
-suicidal ideation and behavior
-Serotonin syndrome
-Discontinuation syndrome
-increase risk of UGI bleeding
Fluoxteine- MOA
Increase the amount of serotonin available in the synapse
-SSRI
Clinical indications for Fluoxetine
MDD
OCD
Panic disorder
bulimia
PMDD
Fluoxetine interactions
Potent inhibitor of CYP2D6 (B-blocker)
Clinical indications for Sertraline
-MDD
-OCD
-panic disorder
-PTSD
-social anxiety disorder
-PMDD
(SSRI)
#1 ADR of Sertraline
nausea
INdications for Paroxetine
mdd
gad
ocd
ptsd
social anxiety disorder
pmdd
paroxetine interactions
strong inhibitor of CYP2D6
ADR's of Parozetine
anticholingeric effects (xerostomia, constipation, sedation)
Indications for Citalopram
treatment of depression and off lable us
indcations of Escitalopram
MDD
GAD
only approved for treatment of OCD
Fluvoxamine
name the 2 SNRI's
Venlafaxine
Duloxetine
indications for Bupropion
-treatment of depression
-adjunct in smoking cessation
ADR's of Buproprion
-orginally associated with seizures in anorexia and bulimia patients, they are contraindicated
common ADR's of Trazadone
Sedation
postural hypotension
hepatotoxicity
ADR's of Mirtazapine
Sedation-more sedation a *lower doses
-*increase in appetite, weight gain
When should baseline ECG's be done for TCA's
>40 yrs
< 40 yrs screen by history, if negative don't need one
tertiary amine TCA's
imipramine
amitrityline
secondary amine TCA's
Desipramine
nortriptyline
interactions of Imipramine
moderate inhibitor of CYP2D6
ADR's of Imipramine
orthostatic hypotension
sedation
anticholingeric effects
clinical indications for amitriptyline
-treatment of depression
-analgesic for certain neuropathies and prophylaxis against migraine headaches
Indications of Desipramine
-depression
-peripheral neuropathies (unlabeled)
good drug to start on for a TCA
Nortriptyline
indications for nortriptyline
depression
peripheral neuropathies (unlabeled)
MAO- name one
Phenelzine
contraindications to MAOI's
unctontrolled HTN
pheo
concurrent use of sympathomimetics
food with a high content of tyramine
clinical indications for MAOI's
"atypical depression" (depression with hyperphagia or hypersomnia)
ADR's of MAOIs
**dizziness due to hypotensive effects
common classes of meds for anxiety
ssri's
buspirone
tca's
benzos
maoi's
combo therapy
clinical indciations for buspirone
GAD
Benzo's to treat anxiety
Alprazolam
Lorazepam
Diazepam
Midazolam
3 phases of general treatment strategies
1. acute phase focuses on symptoms containment/patient safety
2.Continuation phase- goal to reach full remission of symptoms and resotration of functioning
3. maintenance phase aims to sustain remision and lasts >1yr after the resolution of symptoms
1st line pharmacologic therapy for patients with severe manic or mixed episodes
-lithum or valproate
-antipsychotic agent
what is the dosing for LI
0.6-1.3meq/L
interactions of Lithium
Diuretics can lead to lithium toxicity
ADR's of lithium
hypo or hyperthyroidsm
disturbances in the perception of reality, evidenced by hallucinations, delusions, or thought disorganization
psychosis
false sensory perceptions occurring in any of the five snesory modalities
hallucinations
false beliefs that are firmly held despite obvious evidence to the contrary
delusions
pyschotic disorders
schizophrenia
bipolar mania
major depression with psychotic features
-Alzheimer's disease
-delirium
positive symptoms
-hallucinations
-delusions
-thought disorganization
(active psychosis)
(responds to antipsychotic medication)
Negative symptoms
-withdrawal
-anhedonia
-loss of motivation
(correlate with functional impairment)
-responds well to antipsychotics meds, and psychosocial interventions better
low potency conventional anti psychotics
thioridazine
mesoridazine
exhibits a strong alpha-adrenergic blocking effect and depresses the release of hypophyseal/hormones
Chloropromazine
Interactions of Chlorpromazine
-strong inhibitor of CYP2D6
clinical indications for chlorpromazine
control of mania
treatment of schizophrenia
treatment of intractable hiccups
INdications of Haloperidol
-schizophrenia
-Tourette's
Adverse drug reactions for haloperidol
postural hypotension
EPS
NMS
increase prolaction
ADR's of Clozapine
Agranulocytosis
indications for clozapine
treatment-refaractory szhizoprenia
Olanzapine indications
schizophrenia
bipolor
Quetiapine ADR's
weight gain/DM 10-20 lbs
Risperidone ADR's
weight gain/DM
Ziprasidone indications
schizophrenia
acute manic episodes
Aripiprazole indications
schizophrenia
acute manic episodes
what to monitor for atpycial antipsychotics
BMI
fasting lipid profile
fasting blood glucose