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13 Cards in this Set
- Front
- Back
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What determines cell 'life span'? (Replication potential)
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Chromosome structure-terlomeres/telomerase
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Canalization?
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Change in cell's potential to give rise to various specialized types
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Totipotent?
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Can form an entire organism. (Only earliest cells in zygote) (Most flexible)
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Pluripotent?
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Can form cell types/tissues of all 3 germ layers. (Embryonic stem cells)
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Multipotent?
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Can form a few cell types/tissue.
(Adult stem cells like hematopoetic stem cells) (Progenitor cells) |
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Which end of the DNA can the DNA Polymerase NOT replicate fully?
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5' end
(Lagging strand) |
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Which 4 cells are Telomerase normally expressed in?
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Stem Cells,
Sex cells, Very early embryonic cells, Cancer cells |
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Two ways cells can die?
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Apoptosis,
Necrosis |
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What happens in necrosis?
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Cell bursts, organelles released, inflammation
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What happens in the Intrinsic Pathway for DNA damage?
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DNA Damage -- p53 activation -- Proapoptotic Bid, Bax, Bak -- stimulate mitochondria -- activate Cyt C -- activate capase 9 / apoptosome -- activate caspase 9 activate caspase 3 (Executioner Caspase) -- Apoptosis
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What happens in the Extrinsic Pathway from death signals
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Can activate Executioner Caspase directly to start apoptosis, or enter Bid Bax Bak pathway
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What is the anti-apoptotic factor?
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Bcl-2
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What does Bcl-2 inhibit?
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Bak, Bax, Bid,
and cyt C |
