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13 Cards in this Set
- Front
- Back
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Bacteriology
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Aerobic, non-spore forming, gram-negative rod, slightly curved
Motile Facultative anaerobe |
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Structure
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Outer cell membrane - LPS and porin proteins
Pili, flagellum, alginate |
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Extracellular products - Exotoxin A
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enters via endocytosis --> inactivation of EF-2 by ADP ribosylation --> protein synthesis and cell death
Cytotoxic, not systemic |
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Extracellular products - Exoenzyme S
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ADP-ribosylates several intracellular proteins, including the cytoskeleton filament vimentin
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Extracellular products - Elastase
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Breaks down human components
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Epidemiology
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Grows in humidfiers
High risk - neonates IVDA, immunocompromised, burn patients, CF pts |
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Virulence factors
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Exotoxin A
Exotoxin S Elastase |
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Culture & Biochemistry
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Blood agar - hemolytic
Grows at 42C Fruity odor Oxidase +, produces pyocyanin |
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Resistance MOA
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Porin proteins - restrict antibiotic entry
Mutation in target molecule Resistant Abx: penicillin, ampicillin, cephalothin, tetracycline, chloramphenicol, sulfonamides, and the earlier generations of aminoglycosides |
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Treatment - b-lactam antibiotics (selective)
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3rd generation cephalosporins (ceftazidime, cefepime, cefoperazone); Carbapenem (imipenem, meropenem); Monobactams (aztreonam)
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Treatment - Newer aminoglycosides
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Gentamicin
tobramycin amikacin |
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Treatment - Quinolones
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Ciprofloxacin
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Prevention
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Vaccine for burn, CF, immunocompromised patients contains somatic antigens
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