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27 Cards in this Set
- Front
- Back
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Which protozoal parasite has two genetic entities, one pathogenic & the other non-pathogenic?
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Amebiasis
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What is the name of the genetic speices of amebiasis that is pathogenic to humans?
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Histolytica
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Name four strategie with examples that protozoa evolved in order to avoid host reponse?
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1. antigenic variation of surface antigesn (trypanosomes)
2. polymorphisms in surface antigens (malaria) 3. consumption of complement at surface of cell (amoebae) 4. intracellular survival (leishmania, toxoplasma) |
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How do you distinguish between the two genetic entities of histolytica?
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isoenzyme patterns
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Which protozoan infection is one of the three most leading causes of parasitic death?
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amebiasis
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Who are the at risk populations for amebiasis?
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male homosexuals, travelers, recent immigrants, institutionalized populations
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Who gets the disease of amebiasis the worst?
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very young, old & those on corticosteroids
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What is the resevoir for amebiasis?
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Humans, soil
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What protozoal infections have temporal patterns?
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none
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What is the infectious agent of the amebiasis life cycle? What causes disease?
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cysts, trophoziotes
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What are five virulence factors of amebiasis?
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1. galactose-specific adhesin
2. complement lysis resistant 3. extracellular proteases 4. extracellular matrix receptors 5. cell surface lipotroph |
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What is the incubation period for amebiasis?
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1 to 4 wks
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Where does binary fission and feeding of trophoziotes occur?
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lg. bowel
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What are the symptoms of someone w/ an amebiasis infection?
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fever, bloody/pussy stool, feel really sick
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What do the symptoms of amebiasis look like?
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Shigella, dysenntary
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What are the four intestinal syndromes of amebiasis?
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1. asymptomatic colonization
2. acute amebic colitis 3. fulminant colitis 4. ameboma (tumor of bowel wall) |
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Ambiasis eats two things nonstop in humans?
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RBC & intestinal wall
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Which goes deeper into the bowel wall, ambiasis or giardia?
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Amebiasis
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Where in the human body are trophioziotes released in an ambeiasis infection?
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small intestine
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What is the pathological result of trophioziotes invading the bloodstream in an amebiasis infection?
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extraintestinal infection
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What are the three types of disease resulting from an amebiasis infection?
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noninvasive infection (intestinal lumen)
intestinal disease (intestinal mucosa) extraintestinal disease (bloodstream) |
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When are the four intestinal syndromes from an amebiasis infection?
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1. asymptomatic colonization
2. acute amebic colitis 3. fulminant colitis 4. ameboma |
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What are extraintestinal syndromes from an amebiasis infection?
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amebic liver abscess, amebiasis of lunds, brain, gi tract, heart
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How do you diagnose amebiasis?
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stool analysis, antibody detection (IHA, EIA & ID), tissue biopsy, antigen detection of stool
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What is the treatment for an amebiasis infection?
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mild--diloxanide furoate
moderate/severe--metronidazole, tinidazole |
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What are some prevention mechanisms for amebiasis?
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sanitation, clean water supply, public health education, travel precautions
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Is there a vaccine for amebiasis?
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No, but working on developing an antibody to cysteine rich domains of adhesin
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