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35 Cards in this Set

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Drugs for Luminal Protozoa
Metronidazole
Paromomycin (E. hist, back up for Giardia)
Nitazoxanide (Crypto and Giardia in kids)
Metronidazole
Redox reaction in parasites creates radical that dmages DNA

Rabpidly absorped, penetrates CNS

For Giardia, Trich, Amebiasis and for anaerobes

SE N/V, metallic tastes, Disufram reaction with ETOH
Paromomycin
Aminoglycoside

Inhibits protein synthesis in ameoba. Also work on Giardia

SE GI and nephrotoxic. CI in renal disease pts
CI for paromomycin
Patients with renal disease

Aminoglycoside analog that is very nephrotoxic

Work on E. Histolytica and Giardia
Nitazoaxanide
Broads spect anti-parasite that is used mostly for diarrhea in kids

Works on Crypto and Giardia well

GI side effects
Cholorquine
Rapid resistence develops by shuttling out the drug

Drug of choice for malaria except in Haii an dCentral America north of panama canal

Long half life, good penetration, given 1 week

SE GI, visual changes, fatigue and confusion. Can exacerbates dermatoses (psoriasis)
Use for cholorquine resistant falciparum
Qunine, Qunidine
QUinine
Can be combine with doxy or tetracycline or TMP/SMX

SE are cinchonism, hypoglycemia and vasodilation

Increases effects of warfrin, digitalis and NM blockers
Mefloquine
To prevent cholorquine resistent malaria

SE GI and NIGHTMARES

CI pts with epilepsy, psychosis

Interacts with beta blockers and may cause death
Two CI too Mefloquine
Patients with seizures or psyhcosis

Death in patients on beta blockers for heart condition
Doxycycline
Prophylaxis for malaria
Primaquine
Kills hypnozie in ovale and vivax

SE Hemolysis in G6PD pates
Malaria drugs that causes hemolysis
Primaquine in patients with G6P deficiency
Atovaquone + Proguanil
Malaria prophylaxis

Atovaquone also with pyrimethamine for PCP and Toxo

Oral drug, some GI effects
Artemisinin derivatives
Works again falciparum resistent to everything else

Not approved in US due to neurotoxicity
Tx Toxo
Pyrimethamine and Sulfadiazine

P is abosorbe slowly, eliminated by liver

S absorbed rapidly, eliminated by kidney

Given together, but not in same pill

SE P: Megalo Anemia, Rash (S-J)
S: Rash, bone marrow suppresion and hepatotoxicity in AIDS patiens
Tranosoma Brucei Gambiense (west african sleeping sickness
Eflornithine

Absorbed in GI, penetrates CNS

Every expensive

SE N/V anemia, anemia, thrombocytopenia, leukopenia reversible with stopping drug
PCP
TMP/SMX
Pentamidine
TMP/SMX
Give 1:5 ratio for optimal effect

Prophylaxis and treatment of PCP

Many side effects in AIDS patients, teratogenic, S-J syndrome

Thrombocyotpenia if taking thiazides, bleeding with warfarin, lowered phenytoin
Three drug interactions iwth TMP/SMX
Thrombocytopenia with thiazides
Bleeding with Warfarin
Lowered levels of phenytoin
Pentamadine
Given IV or inhaled

Works on PCP, Sleeping sickness, Leishmanisis

SE Hypotension, tachycardia, hypoglycemia (attacks beta cells) and blood discrasias
Nematodes
Albendazole
Pyrantel Pamoate
Ivermectin
Dethycarbamazine
Albendazole
Depletes glycogen in parasite

Take with a fatty meal, and give with dexamethasone

Single does for worms
Aso for neurocysticercosis and giardia
How to increases the absorption of albendazole
Give with fatty meal and dexamethasone
Pyrantel Pamoate
NM block of parasites
For enterobiasis, ascariasis, but NOT wipworm

Not well absorbed
SE GI and headache

Antagonize piperazine, another worm drug
Ivermectin
DOC for Strongyloides, Onchocerciasis (river)

SE Itching, lymph nodes, dizziness
Diethylcarbamazine
For lymphatic filarisis an dLoa Loa

Put in table salt in endemic areas

Mazzotti reaction: pruritis, fever, hypotension, facial edema and eosinophilia

Also Eye side effects
Mazzotti reaction
Pruritis, fever, hypotension, facial edema and eosinophilia when using Diethylcarabmazine for Nematodes
Flukes and Tape worms
Praziquantel

Paralyzes worm so body can fight it

SE headache, dizziness, malaise
Ectoparasites
Permethrin, Lindane amd Diethyltoluamide
Permethrin
Killes head lice, ticks, fleads mites

Used in clothes and bed nets to limit mosquito bites

Causes erythema, numbness, tinglin and rash in 1-2%
Lindane
Lotion for Tx of scabies

Convulsions if injested
Tx for scabies
Lindane
Diethyltoluamide
DEET

Encephalopathy with high application in small kids
Primaquine
Pyrimethamine
Pentamidine
Praziquantel
Permethrin
Primaquine - Malaria
Pyrimethamine - w/ sulfadiazine for Toxo
Pentamidine - PCP
Pyrantel Pamoate - Nematodes
Praziquantel - Flukes and Cestodes
Permethrin - Insect repelant