Proto-Oncogenes / Tumor Supressors, Etc

Front 1

Chronic Myelogenous Leukemia
1. gene
2. fxn
3. mutation

Back 1

1. ABL
2. Protoncogene - tyr kinase (2nd messenger)
2. Philadelphia Chromosome t(9:22) translocation

Front 2

Breast Carcinoma (marker of aggressiveness)

Back 2

1. Her2
2. Proto-oncogene - receptor synthesis (makes cell more responsive to hormones)
3. amplification

Front 3

Burkitt's Lymphoma

Back 3

1. Myc
2. Proto-onc: transcription factor
3. Translocation t(8:14)

Front 4

Neuroblastoma

Back 4

1. N-myc
2. Proto-oncogene: transcription factor
3. amplification

Front 5

Leukemia; lung, colon, pancreatic carcinomas
(MEN)

Back 5

1. Ret
2. Proto-oncogen: Receptor synthesis
3. point mutation

Front 6

Osteogenic Sarcoma, astrocytoma

Back 6

1. SES
2. Proto-onc: Growth factor
3. Overexpression

Front 7

Familial Polyposis (CRC)

Back 7

1. APC
2. Tumor suppressor: prevents transcription by degrading catenin

Front 8

Breast, Ovary, prostate carcinoma

Back 8

1. BCL1 & 2
2. Tumor suppressor - DNA repair

Front 9

Retinoblastoma
1. gene
2. fxn
3. other cancers

Back 9

1. RB chr 13
2. G1 --> S regulation (suppressor)
3. Osteogenic sarcoma, breast carcinoma

Front 10

Pancreatic and CRC

Back 10

1. TFG-beta
2. G1 -->S

Front 11

Lung, colon, breast carcinomas

Back 11

1. P53
2. Inhibitis G1-->S, repairs DNA, activates BAX (initiates apoptosis)

Front 12

VHL
1. Gene fxn
2. Syndrome - what cancers involved?

Back 12

1. Transcription regulator
2. Bilateral renal cell carcinoma, bilateral pheochromocytoma, retinal angioma, cerebellar hemangioblastoma

Front 13

WT1

Back 13

1. regulates nuclear transcription
2. Wilm's tumor (blastic renal tumor in children)