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19 Cards in this Set
- Front
- Back
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Native conformation
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3D structure for a particular protein that allows it to be active and/or functional.
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Denaturation
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loss of native conformation adn resulting loss of activity
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Primary protein structure
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Linear sequence of amino acids from N to C termini.
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What holds primary structure together?
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Covalent interactions - the peptide bonds
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Secondary protein structure
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Folding of proteins by H bond interactions among backbone atoms.
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What holds secondary structure together?
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H bond interactions
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Folding of protein in secondary structure involves what atoms?
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Backbone
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Tertiary protein structure
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3D arrangement of atoms of protein within a single polypeptide.
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Folding of protein in tertiary structure involves what atoms?
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R groups
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What interactions are possible for tertiary protein structures?
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H bonding, hydrophobic, electrostatis (attractive, repulsive) and covalent
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Quarternary protein structure
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3D arrangment of atoms of protein among more than one polypeptide.
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Folding of protein in quarternary structure involves what atoms?
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R groups
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What interactions are possible in quarternary protein structure?
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H bonding, hydrophobic, electrostatic (attractive, repulsive) and covalent.
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Shape of the alpha helix?
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Rod-like
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How many polypeptide chains does an alpha helix involve?
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Only one
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How is the alpha helix stabilized?
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H bonds parallel to the helix axis within the backbone of a single polypeptide chain.
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How many polypeptide chains does a beta sheet involve?
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One or more
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What are the two forms of beta sheets?
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1. Parallel (N to C in same direction)
2. Antiparallel (N to C paired with C to N) |
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What are some things that can disrupt an alpha helix?
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1. Proline
2. Electrostatic repulsion 3. Steric crowding |
