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33 Cards in this Set
- Front
- Back
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what are some mechanisms of resistance
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altered target site
drug inactivation decreased permeability abx efflux pump |
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which is good for g+, atypicals, some g - and inhibits elongation and translocation via binding to the 50s subunit ANDDDDDDDDDDD is good for respiratory disieases:
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macrolides
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what does clarithromycin treat specifically:
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it is for h. pylori
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what is azithromycin used for?
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chlamydia
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which is IV and PO and which is only PO?
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iv and po = erythromycin/azithro
clarithro is PO only |
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what are some problems with erythromycin as far as SE?
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short half life
GI side effects cholestatic hepatitis epigastric distress |
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what has a high affinity for sites 2 and 5 and ovecomes macrolide resistance?
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telithromycin (ketek) a ketolide
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although it is similar to macrolides, there are a few differences in SE. what are they
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visual disturbances and hepatotoxicity
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it used to be approved for sinusitis and chronic bronchitis, now it is only approved for what?
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CAP
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this is used for CA-MRSA, anerobes, and osteomyelitis, cellulitis. its side effect = SEVERE DIARRHEA. what am i?
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clindamycin
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This inhibits the initiation complex from forming and is good against MRSA, enterococcus faecalis and VRE enterococcus
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linezolid (oxazolithiones)
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when switchin over from IV vanco, what drug should you get put on?
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linezolid = PO doc
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what are some SE with linezolid?
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thrombocytopenia, need weekly CBC's
myelosuppression serotonin syndrome - be careful with concomitant serotonergic agents |
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this drugs main role is against vancomycin resistant enterococci faceium
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streptograminin
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what is the MOA for streptogramin
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interferes with elongation via binding to 50s ribosome
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what are some SE with streptogramin?
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myalgias, drug interactions with cytochrome p450 enzymes
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this inhibits the binding of trna to mrna ribosome complex and also is NOT kid friendly
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tetracycline
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which drug of the TCN group is excreted in urine and is taken PO
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TCN
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which is the DOC for poor kidney function and is good for atypicals and has better pentration into the eye, lung, and GU
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doxycycline
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what are some SE of tcn?
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photosensitivity
tooth discoloration deformation of bones/growth |
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which is used to treat RA, CA-MRSA but is limited d/t SE
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minocycline
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what microoragnisms does TCN take care of?
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gram +, strep pneumonia, atypicals
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what is IV only and takes care of acinetobacter, csssi, and intraabdominal infections
it also overcomes TCN resistance mechanisms |
tigecycline
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this drug must be adjusted for hepatic impariment
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tigecycline
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this is a drug that is practically obselete, is used for CNS infections
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chloramphenicol
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this drug can give you gray baby syndrome as a side effect
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chloramphenocol
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this class of drugs absolutely requires O2 and does active transport.
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aminoglycosides
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which aminoglycosides is used for pseudomonas and acinetobacter? what is used for serratia mercescens?
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tobramycin = pseudomonas and acinteobacter
gentamicin= serratia mercescens |
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how do they gain resistance?
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porin channels close or there is a decrease in # of channels
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what do you always pair an aminoglycoside with?
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beta lactam for synergy
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what should you advise your pt to do when on aminoglycosides?
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stay hydrated
avoid nephrotixic and ototixc agents |
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how are aminioglycosies eliminated?
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renally
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T OR F: must monitor peaks and trough
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true.
peaks = efficacy trough= toxicity |
