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24 Cards in this Set
- Front
- Back
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Name the Aminoglycosides
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1. Gentamicin
2. Neomycin (topical) 3. Amikacin 4. Streptomycin (-CIN) |
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What is the MoA of aminoglycosides?
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- Inhibit protein syntheis (30s)
- Cidal |
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What are unique SE of aminoglycosides?
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1. Nephrotoxicity
2. Ototoxicity (irreversible) 3. Teratogen 4. Neurotoxicity |
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When is an aminoglycoside used?
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Severe aerobic gram - ROD infections
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Name the Tetracyclines:
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1. Tetracycline
2. Doxycycline 3. Minocycline 4. Demeclocyline (- CYCLINE) |
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What is the MoA of tetracyclines?
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Inhibit protein synth (30s)
- selective toxicity (bacterial cells) |
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What are unique SE of Tetracyclines?
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1. photosensitivity
2. discoloration of permanent teeth + inhibition of bone growth |
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When are tetracylcines used?
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VACUUM THe BedRoom:
Vibrio cholerae Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. pylori Borrelia Burgdoferi (lyme) Rickettsia |
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When is Doxycycline used?
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1. exotic- intracell pathogens:
- spirochetes - tick transmitted dz - plasmodium 2. DoC for Chlamydia and Gonorrhea |
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When is Minocycline used?
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common skin infections
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When is Demeclocycline used?
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ADH antagonist - diuretic in SIADH
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Name the macrolides:
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1. Erythomycin
2. Azithromycin 3. Clarithromycin (-THROMYCIN) |
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What is the MoA of macrolides?
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inhibits protein synthesis (50s)
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What are unique SE of Macrolides?
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1. prolonged QT (esp erythro)
2. GI intolerance (mainly erythro) 3. P450 inhibitor |
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When are Macrolides used?
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1. URIs
2. Pneumonias 3. STDs - gram + cocci |
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Which Macrolides are DoC for Legionella and Chlamydia?
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Clarithromycin
Azithromycin |
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What is the MoA of Chloramphenicol?
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Inhibits protein synthesis (50s)
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What are unique SE of Chloramphenicol?
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1. aplastic anemia
2. Gray baby syndrome |
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When is Chloramphenicol used?
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NOT used due to toxicity
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What is the MoA of Clindamycin?
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Inhibits protein synthesis (50s)
Facillitates opsonization, phagocytosis, and intracellular killing |
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What are the SE of Clindamycin?
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Diarrhea due to pseudomembrane colitis (C. difficile overgrowth)
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When is Clindamycin used?
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1. Anaerobes ABOVE diaphragm
2. Mixed aerobic/anaerobic gyn or intra-abdominal infections |
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but AT 30
CCELL at 50 |
30s inhibitors:
- A= aminoglycosides - T = tetracyclines 50s inhibitors: - C = Chloramphenicol - C = Clindamycin - E = Erythromycin - L = Lincomycin - L = Linezolid |
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Which one is NOT static?
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Aminoglycosides are CIDAL
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