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19 Cards in this Set
- Front
- Back
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Tetracyclines MOA
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MOA: Bind 30s ribosomal subunit; bacteriostatic
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Tetracyclines usage
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tigercycline has broadest spectrum; use for chlamydiae, mycoplasma, rickettsiae, spirochetes, and H. pylori; treatment of acne (low dose); Oral, IV
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Tetracyclines Toxicities
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GI upsets; deposition in developing bones and teeth, photosensitivity, superinfection
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Macrolides: Drugs
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Erythomycin, Azithromycin, clarithromycin, telithromycin
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Macrolides MOA
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Bind to 50S subunit; bacteriostatic; least resistance to telithromycin
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Macrolides Usage
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Community aquired pneumonia, pertussis, cornynebacteria, and chlamydial infections; Oral, IV
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Macrolides Toxicities
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GI upsets; hepatic dysfunction; QT elongation; CYP450 inhibiton (not azithromycin)
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Lincosamide MOA
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Bind to 50S ribosomal subunit; bacteriostatic
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Lincosamide Usage
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Skin, soft tissue, and anaerobic infections
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Lincosamide Toxicities
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GI upsets; C difficile colitis
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Lincosamide Drugs
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Clindamycin
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Streptogramins Drugs
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Quinupristin-dalfopristin
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Streptogramins MOA
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Binds to 50s ribosomal subunit; bacterialcidal
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Streptogramins Usage
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Staphylococcal infections, vancomycin-resistant E. faecium
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Streptogramins Tox
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Infusion related arthralgia and myalgia; CYP450 inhibition
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Chloramphenicol MOA
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Binds to 50s ribosomal subunit; bacteriostatic
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Chloramphenicol Usage
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Wide spectrum, but mainly backup
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Chloramphenicol Tox
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Dose related anemia, gray baby syndrome
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Linezoild MOA
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Binds to 23S RNA of 50S subunit; bacteriostatic
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