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29 Cards in this Set
- Front
- Back
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Erythromycin
(class, MoA) |
macrolide
Binds domain V of 50S ribosome |
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Erythromycin
(resistance) |
efflux pump
mutation at ribosomal binding site methylation of ribosomal binding site (INDUCES methyltransferases) |
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Clarithromycin
(class, MoA, adverse rxn) |
Macrolide
binds domain V of 50S ribosome CNS disturbances (mania) |
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Azithromycin
(class, MoA) |
macrolide
binds domain V of 50S ribosome |
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Azithromycin
(absorbtion & spectrum) |
pneumococci, strep, staph, mycoplasma, legionella, chlamydia, MAC, H.flu
very high tissue conc (acts as reservoir) |
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Telithromycin
(class & MoA & treatment of) |
ketolide
binds domains II and V of 50S ribosome treatment of comm acquired pneumonia |
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Clindamycin
(class & MoA & adverse effect) |
Lincosamide
binds domain V of 50S ribosome pseudomembranous colitis |
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Clindamycin
(absorption & spectrum) |
affinity for osseous tissue (bone infections)
spectrum includes MRSA & B.frag |
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Quinupristin/Dalfopristin
(class & MoA) |
streptogramin
binds a site on 50S ribosome |
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Quinupristin/Dalfopristin
(spectrum & adverse effect) |
Gm+ ONLY
effective against many drug resistant bacteria (VREF, MRSA, MDR S.pneumo) arthralgias & myalgias |
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Linezolid
(class & MoA) |
Oxazolidinone
Binds 50S ribosome |
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Linezolid
(spectrum & adverse effects) |
Gm+ ONLY
VRE, MRSA & MDR resistant S. pneumo myelosuppression, anemia, serotonin syndrome |
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Chloramphenicol
(MoA & adverse effects) |
binds 50S ribosome
aplastic anemia, anemia, gray baby syndrome |
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Tetracycline
(class & MoA) |
tetracyclines
inhibits 30S ribosome |
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Tetracycline
(resistance & spectrum) |
efflux pump
rickettsiae, chlamydiae, mycoplasmas, H.pylori, plasmodia, amoebas |
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Tetracycline
(adverse reactions) |
hypersensitivity, GI, phototoxic reaction, hepatic dysfunction, discoloration of teeth, depressed bone growth (binds Ca2+)
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Minocycline
(class & MoA) |
tetracyclines
inhibits 30S ribosome |
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Minocycline
(adverse effects) |
vertigo & dizziness
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Doxycycline
(class & MoA & primary use) |
tetracyclines
inhibits 30S ribosome chlamydia |
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Tigecycline
(MoA) |
HIGH affinity for 30S ribosome
unaffected by efflux pump |
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Tigecycline
(spectrum) |
broad spectrum
MRSA, VRE, PRSP, carbapenem resistant actinobacter |
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Gentamicin
(class & MoA) |
aminoglycosides
interferes w attachment of mRNA to 30S ribosome (initiation) |
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Tobramycin
(class & MoA) |
aminoglycosides
interferes w attachment of mRNA to 30S ribosome (initiation) |
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Amikacin
(class & MoA) |
aminoglycosides
interferes w attachment of mRNA to 30S ribosome (initiation) |
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Aminoglycosides spectrum
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Gm(-) AEROBES
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Aminoglycosides dosing
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based on lean body mass
once daily dosing minimizes SEs (lower trough levels) |
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Aminoglycosides resistance
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due to metabolism by bacteria to inactive compounds
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Aminoglycosides adverse reactions
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ototoxicity, nephrotoxicity, neuromuscular blockade
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what does uptake of aminoglycosides depend on?
how does this relate to spectrum? |
O2
Gm- aerobes |
