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44 Cards in this Set
- Front
- Back
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Aminoglycoside
Tetracycline |
30S
|
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Chloramphenicol
Macrolide Lincosamide Streptogramin Oxazolidinone Daptomycin |
50S
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Streptomycin
Gentamicin Tobramycin Amikacin Neomycin |
Aminoglycoside (30S)
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Tetracycline
Doxycycline Minocycline Tigecycline |
Tetracycline (30S)
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Erythromycin
Clarithromycin Azithromycin |
Macrolide
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Clindamycin
|
Lincosamide
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Quinopristin/Dalfopristin
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Streptogramin
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Linezolide
|
Oxazolidinone
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Aerobic Gram (-) Bacilli
Enterobacter Proteus Pseudomonas (DOC) Serratia |
Aminoglycoside
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Invasive Enterococcal Infection (DOC)
Serious Staphylococcal Infection |
Aminoglycoside
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Francisella tularensis (DOC)
Yersinia pestis |
Aminoglycoside
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Irreversible Bind 30S Ribosome
Bactericidal |
Aminoglycoside
|
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Block Initiation Complex
Miscode Peptide Chain Block Translocation |
Aminoglycoside
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Anaerobic Environment
Low Extracellular pH |
Aminoglycoside
Transport Block |
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Aminoglycoside Modifying Enzyme
|
Acetylation
Adenylation Phosphorylation |
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Consolidate Aminoglycoside Therapy
|
Single Daily Dose
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Comparable Efficacy
Decrease Nephrotoxicity |
Consolidate Aminoglycoside Therapy
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Post Antibiotic Effect
Concentration Dependent Kill |
Consolidate Aminoglycoside Therapy
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Nephrotoxicity
Neuromuscular Block Ototoxicity |
Aminoglycoside
Adverse |
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Reversible
Acute Tubular Necrosis (25%) Decrease Aminoglycoside Excretion Concentration/Time Dependent |
Aminoglycoside
Nephrotoxicity |
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Irreversible (25%)
Tinnitus/High Frequency Hear Loss Vestibular Damage Concentration/Time Dependent |
Aminoglycoside
Ototoxicity |
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Postoperative Respiratory Depression
Calcium Gluconate/Neostigmine |
Aminoglycoside
Neuromuscular Block |
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Myasthenia Gravis
|
Aminoglycoside
Absolute Contraindication |
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Tularemia
Plague Tuberculosis Brucellosis (DOC) Bacterial Endocarditis |
Streptomycin
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Pseudomonas (DOC)
Enterococcus (DOC) |
Gentamicin
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Pseudomonas
Resistent to Aminoglycoside Modifying Enzyme Use Aminoglycoside Fail |
Amikan
|
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Oral Sterilize Gut
Topical |
Neomycin
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Aerobic/Anaerobic
Gram (-)/Gram (+) Intracellular Protozoa |
Tetracycline
|
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Mycoplasma
Chlamydia Rickettsiae Lyme Disease Bacillus anthracis (Ciprofloxacin) |
Tetracycline
DOC |
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Plague
Tularemia Brucellosis Malaria Prophylaxis Cholera |
Tetracycline
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Bacteriostatic
Reversible Bind 30S Ribosome tRNA Bind Acceptor Site Amino Acid Grow Peptide |
Tetracycline
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PO, IV, Topical
Chelate with Cation Avoid Milk, Antacid, PeptoBismol |
Tetracycline
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Wide Distribution
Chelate with Calcium Concentrate Bone and Teeth |
Tetracycline
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Therapeutic Concentration
CSF |
Minocycline
|
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No Dose Adjustment
Decrease Renal Function |
Doxycycline
Minocycline |
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Glycylcycline Derivative of Minocycline
MRSA PRSP VRE |
Tigecycline
|
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IV
Resistant to Tetracycline Resistance Mechanism Complicate Skin Infection Intraabdominal Infection CAP Not UTI |
Tigecycline
|
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Gastrointestinal
Bony Structure/Teeth Liver Toxicity Local Tissue Toxicity Photosensitivity Vestibular |
Tetracycline
Adverse |
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PO
N/V/D Distinguish Pseudomembranous Colitis |
Tetracycline
Gastrointestinal |
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Bind Calcium
Deformity/Inhibit Growth |
Tetracycline
Bony Structure/Teeth |
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Thrombophlebitis IV
Pain IM (Avoid) |
Tetracycline
Local Tissue Toxicity |
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Minocycline
Ataxia Dizziness N/V |
Tetracycline
Vestibular |
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Pregnancy
Common Infection Under 8 Year of Age Discard or Degrade (Fanconi Syndrome) |
Tetracycline
Precaution |
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N/V
Acidosis Aminoaciduria Glycosuria Polydipsia Polyuria Proteinuria |
Fanconi Syndrome
|
