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8 Cards in this Set
- Front
- Back
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Erythromycin
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Macrolide
binds 23S rRNA of 50S subunit; inhibits CYP3A4 Bacteriostatic cross resistance bt macrolides pneumococci, strep, staph, Mycoplasma pneumonia, legionella |
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Clarithromycin
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Macrolide
binds 23S rRNA of 50S subunit more active vs. staph & strep broader spectrum less GI upset; inhibits P450 |
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Azithromycin
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Macrolide
binds 23S rRNA of 50S subunit pneumococci, strep, staph, Mycoplasma pneumonia, legionella, chlamydia, H.influenzae, Mycobacterium avium 10-100X [tissue] vs. Emycin - give shorter time |
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Telithromycin
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Ketolide
conacts Domain II & IV of 23S rRNA of 50S subunit=no resistance Tx Comm. Aquired Pneumonia |
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Clindamycin
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Lincosamide
binds 23S rRNA of 50S subunit Gm+, Staph, Strep, CA-MRSA, Anaerobes above the diaphram |
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Synercid
quinupristin/dalfopristin 30:70 |
bind diff sites on 50S ribosome
Gm+, nosocomial infections Vanc-resistant Enterococci faecium (VREF) & MRS.aureus/pyogens |
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Linezolid
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oxazolidinones
binds 50S subunit Gm+ only VRE & MRSA ~100% oral bioavailalbility |
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Chloramphenicol
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Nitrobeneze
binds 50S subunit anaerobic CNS infections aplastic anemia reversible BM suppression Gray-baby syndrome |
