Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

14 Cards in this Set

  • Front
  • Back
Benign prostatic hyperplasia
nodular enlargement of the anterior/periurethral regions (transition zone) of the prostrate
pathogenesis of benign prostatic hyperplasia
increased DHT, increased androgen receptors
clinical features benign prostatic hyperplasia
reduced urinary stream; nocturia; predisposes to UTI, bladder stone; hydronephrosis; rectal exam can detect
gross appearance of BPH
markedly enlarged; nodular expansion in the periurethral regions (TZ); pink-tan and fleshy to gray and firm.
BPH histology
mixture of benign glands and fibromuscular stroma; equal admixture of glandular and stromal element, similar to normal prostate morphology (long elongated glands)
TURP (transurethral resection) specimens
large number of prostate “chips” (curettings) , irregularly shaped fragments 5-10mm,
treatment and prognosis of BPH
TURP removal of obstructing portion; finasteride, alpha blockers
Prostate cancer incidence
most common non-skin cancer of males in US. 2nd hightest cause of cancer death. incidence progresses to 80% by 80
prescursor lesions of prostate cancer
peripheral zone develop from precursos lesiosn: Prostatic intraepithelial Neoplasia (PIN).
serum PSA
screening for prostate cancer; serine protease secreted by prostate epithelium; may be elevated when tumors still confined to prostate; 4ng/ML carcinoma in 1/4 . percent free to bound, low ration worse. PSA useful for pt monitoring after treatment
gross pathology of prostate cancer
difficult to recognize grossly, solid tan-tray or yellowish areas
histopathology of prostate cancer
small crowded or infiltrating glands with nuclear enlargement and prominent nucleoli; glands lose their two cell lining (only one cell type present, normal glands have a basal cell layer). basal cell layer selectively stained using antibodies to high molecular weight keratin.
Prostatic intraepithelial neoplasia (pin) histology
macronucleioli characteristic of high grade PIN.
treatment of prostate cancer
cut it out, hormonal manipulation with metastises: estrogens, orchiectomy. damn.