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15 Cards in this Set
- Front
- Back
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Eicosanoids:
Two main groups: PG AND leukotrienes |
oxygenation products of poly-unsaturated long-chain fatty acids such as arachidonic acid
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Phospholipase A2
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Enzyme in the cell membrane that generates arachidonic acid from lipid constituents
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COX
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converts arachidonic acid to PGG and PGH (precursors of prostaglandins)
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Lipoxygenase Enzyme
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converts arachidonic acid to leukotriene precursors(HPETE)
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Prostaglandins
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Misoprostol (Cytotec)
Epoprostenol (Flolan) Dinoprostone (Prostine 2) Treprostinil (Remodulin) Alprostadil (Caverject, Prostin VR Pediatric) Bimatoprost (Lumigan) Travaprost (Travatan) Unoprostone (Rescula) Latanoprost (Xalatan) |
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Misoprostol used:
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NSAIDs induced ulcers
synthetic PGE1 analog. |
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Misoprostol Adverse Effect:
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Abdominal discomfort
Diarrhea. |
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Dinoprostone (PGE 2)ADM.
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administered vaginally
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Dinoprostone approved:
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1. induced abortion in second tri.
2. missed abortion 3. benign hydatiform mole 4. ripening of cervix for induction of labor in patients near term. (Affects the collagenase of the cervix) |
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Alprostadil used for:
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1. Patent ductus arteriosus
2. Intracavernosal injection or urethral supp. 3. erectile dysfunction 4. acts as smooth muscle relaxant, increased blood flow, erection. |
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Alprostadil side effect:
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1. penile pain
2. penile fibrosis 3. flushing, diarrhea, HA, FEVER. |
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Latanprost used for:
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long acting PGF2a
1. glaucoma or ocular hypertension. |
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Unoprostone used to:
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Increase uveoscleral outflow of aqueous humor
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Adverse Effect of unoprostone:
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Iris pigmentation
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Epoprostenol (PGI2)
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Pulmonary hypertension
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