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37 Cards in this Set

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_ is permanent amenorrhea in a previously cycling woman.
menopause; caused by exhaustion of the ovaries
_ is the term referring to the period around menopause.

-anovulation
-perimenopause
-climacteric
climateric
E1 = ?
E2 = ?
E3 = ?
E1 = estrone
E2 = estradiol
E3 = estriol
at menopause the greatest reduction is in?

-E1
-E2
-E3
E2-estradiol
E1 which is primarily produced by _ increases when E2 goes down.

-muscle
-parietal cells
-fat
fat cells
the mean age of menopause is?

-47.2
-51.3
-52.7
-55.9
51.3 years
premature menopause is defined as menopause before age _.

-30
-35
-40
-45
40
what is the MCC of hysterectomy?

-uterine CA
-fibroids
-DUB
-endometrial CA
fibroids in 45-54 y.o.
hyperplasia in 55-64 y.o.
uterine prolapse >65
menopause is diagnosed retrospectively-1 year after LMP. although, it is now being diagnosed with an FSH level > _.

-20
-35
-40
-55
>40mIU/mL
what is the MCC of menopausal women?

-vasomotor symptoms
-mood disturbances
-sleep disturbances
-urogenital symptoms
vasomotor; hot flashes!!
t/f

obese women have less vasomotor symptoms than non obese women
false; it is more often with obese women
what is the medication treatment of vasomotor symptoms?

-low dose estrogen plus testosterone
-low dose estrogen
-testosterone only
low dose estrogen plus testosterone
which of the following meds is most effective in reducing vasomotor symptoms?

-paroxetine
-clonidine
-gabapentin
-megestrol
gabapentin
t/f

normal vaginal bacterial flora is dominated by lactobacillus
true
t/f

normal vaginal ph is 3.5-4.5, and after the decline of estrogen with menopause, tissue thins, and with less glycogen=less lactobacillus and the vaginal pH rises to 5.5-6.8....vaginal atrophy
true; treatment of atrophic vaginitis is low dose topical estrogen or replens tiw. semen may help to maintain low pH.
cancellous bone is most frequently lost and is concentrated in the _ & _.

-spine
-long bones
-sternum
-tibia/fibula
spine and long bones
Increased _ activity in the immediate postmenopausal period causes an imbalance between bone resorption and formation.

-osteoblastic
-osteoclastic
osteoclastic
the risk factors for osteoporosis include all except?

-caucasion
-sedentary lifestyle
-high levels of body fat
-low levels of body fat
-poor intake of vit d/calcium
-northern european descent
high levels of body fat is good
which 2 of the follow meds can cause osteoporosis?

-insulin
-hyperthyoidism
-glucocorticoids
-glucose
hyperthyroid and glucocorticoids
t/f

progesterone alone is an effective therapy for osteoporosis
false;
primary prevention of osteoporosis includes what?
smoking cessation
wt. bearing exercise
good amount of ca & vit d
ET has been shown to help too
what is the USPSTF recommendation for the evaluation of osteoporosis? And for those pt's with risk factors?
65 for routine screening, and between 60-64 for people at risk
if bmd score is less than 1 SD but not less than 2.5 then the diagnosis is ?

-osteoporosis
-normal
-osteopenia
osteopenia

>2.5 SD is osteoporosis
what is the best treatment for osteoporosis?

-testosterone only
-progestin only
-estrogen only
-estrogen/testosterone
-estrogen/progestin
estrogen/testosterone (estratest)
35mg of fosamax is for the _ of osteoporosis.
prevention
what is the dose of fosamax to be given for the tx of osteoporosis?
70mg po weekly
which is the number one preventative measure of osteoporosis?

-wt. bearing exercises
-calcium
-bisphosphonates
-smoking cessation
-vit d
smoking cessation
what is the MC cardiovascular adverse event with CHT?

-vte
-cva
-mi
vte
t/f

the WHI study of CHT was stopped when the increase in risk of breast cancer with active tx became statistically significant
true
t/f

the WHI showed a slight increase in risk of the diagnosis of Alzheimer's disease
true
which of the following SERM's is the only approved med for the tx of metatastic breast CA?

-toremifene
-raloxifene
-tamoxifene
toremifene
the FDA has approved the use of _ for the prevention of breast CA.

-toremifene
-raloxifene
-tamoxifene
tamoxifen; 45% decrease in RR for breast CA but 3x risk for VTE
what is the MC s/e of tamoxifen?

-endometrial hyperplasia
-AUB
-inc. risk of endometrial CA
-vasomotor symptoms
vasomotor, in 17% of pt's
t/f

tamoxifen has a positive effect on the lipid profile
true
t/f

there is slight increase in the risk of stroke with tamoxifen
true
t/f

raloxifen has been approved for the tx osteoporosis although is less effective than estrogen
true
phytoestrogens are plant substances that are functionally similar to _.

-E1
-E2
-E3
E2