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23 Cards in this Set

  • Front
  • Back
Hyperprolactinemia causes
infertility

Suppresses LH and FSH
What stimulates prolactin
TRH
Estrogen
Inhibits prolactin
Dopamine
Tx for hyperprolactinemia
Bromocriptine
Half life of bromocriptine
3hours
SE of bromocriptine
Nausea, Dizzines, Orthostatic hypotension

Psychosis in small percent
How do you minimize SE of bromocriptine
Start low and go slow
Three drugs that act on the pituitary GH secretion
GHRH (stim)
Ocetotride (inhib)
Bromocriptine (inhib)
Use for GHRH
Enhance growth hormone secretion

Diagnostic for pituitary function
Effect of continuous (non-pulsitile) GHRH administration
Continuous GH secretion by somatotropes

Contrast with GnRH which desensitizes receptors if given continuously
Most effective inhibitor of GH secretion
Octeotride

Bromocriptine also works, but not as well
effects of somatostatin and the synthetic analog used for therapy
Brain: Inhibits GH secretion

GI: inhibits gastric motility, reductions splanchnic flow and inhibits hormones (insulin, glucagon, VIP)

Octeotride is somatistatin analog
Use for octeotride

SE?
Acromegaly
VIPomas (pancrease)
Carcinoids tumors
Variceal bleeding

SE are GI & gall stones
Recombinent GH
somatropin
GH peak levelsq
At night, during first deep sleep
Conditions that enhance GH release
Androgens, cortisol, exercise, hypoglycemia
Main effect of GH
Secret IGF
Laron-type dwarf
Normal to high GH but mutated GH receptor so low IGF

Give IGF
Uses for somatropin
GH deficiency (kids, adult)
Gonadal dysgenesis (45 X,0)
growth failure from renal failure
SE of GH
hyperglycemia leading to Diabetes mellitus
Effects of IGF
bone growth
tissue growth
cell differentiation
Use of IGF
Laron type dwarfism
Second-line (after GH) for hypopituitary dwarfism
SE of IGF
hypoglycemia

(insulin-like)