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23 Cards in this Set
- Front
- Back
Hyperprolactinemia causes
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infertility
Suppresses LH and FSH |
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What stimulates prolactin
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TRH
Estrogen |
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Inhibits prolactin
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Dopamine
|
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Tx for hyperprolactinemia
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Bromocriptine
|
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Half life of bromocriptine
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3hours
|
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SE of bromocriptine
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Nausea, Dizzines, Orthostatic hypotension
Psychosis in small percent |
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How do you minimize SE of bromocriptine
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Start low and go slow
|
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Three drugs that act on the pituitary GH secretion
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GHRH (stim)
Ocetotride (inhib) Bromocriptine (inhib) |
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Use for GHRH
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Enhance growth hormone secretion
Diagnostic for pituitary function |
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Effect of continuous (non-pulsitile) GHRH administration
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Continuous GH secretion by somatotropes
Contrast with GnRH which desensitizes receptors if given continuously |
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Most effective inhibitor of GH secretion
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Octeotride
Bromocriptine also works, but not as well |
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effects of somatostatin and the synthetic analog used for therapy
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Brain: Inhibits GH secretion
GI: inhibits gastric motility, reductions splanchnic flow and inhibits hormones (insulin, glucagon, VIP) Octeotride is somatistatin analog |
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Use for octeotride
SE? |
Acromegaly
VIPomas (pancrease) Carcinoids tumors Variceal bleeding SE are GI & gall stones |
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Recombinent GH
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somatropin
|
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GH peak levelsq
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At night, during first deep sleep
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Conditions that enhance GH release
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Androgens, cortisol, exercise, hypoglycemia
|
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Main effect of GH
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Secret IGF
|
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Laron-type dwarf
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Normal to high GH but mutated GH receptor so low IGF
Give IGF |
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Uses for somatropin
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GH deficiency (kids, adult)
Gonadal dysgenesis (45 X,0) growth failure from renal failure |
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SE of GH
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hyperglycemia leading to Diabetes mellitus
|
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Effects of IGF
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bone growth
tissue growth cell differentiation |
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Use of IGF
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Laron type dwarfism
Second-line (after GH) for hypopituitary dwarfism |
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SE of IGF
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hypoglycemia
(insulin-like) |