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101 Cards in this Set
- Front
- Back
Renal cortex
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A granular superficial region
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• Renal medulla
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• The cone-shaped medullary (renal) pyramids
separated by renal columns |
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• Lobe
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• A medullary pyramid and its surrounding
cortical tissue |
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• Major calyces
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• The branching channels of the renal pelvis that
• Collect urine from minor calyces • Empty urine into the pelvis |
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kidneys lateral surface
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convex lateral surface
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renal hilum leads to
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renal sinus
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concave
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medial
surface of kidneys |
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renal pelvis
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funnel shaped tube within renal sinus
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papila
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the tip of pyramid, releases urine into calyx
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2 main parts of nephron
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Two main parts
1. Glomerulus: a tuft of capillaries 2. Renal tubule: begins as cup-shaped glomerular (Bowman’s) capsule surrounding the glomerulus |
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renal corpuscle =
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glomerulus and its capsule
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2 layers of renal tubule
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-Parietal layer: simple squamous epithelium
• Visceral layer: branching epithelial podocytes |
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Parietal layer:
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simple squamous epithelium
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• Visceral layer
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branching epithelial podocytes
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podocytes
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Extensions terminate in foot processes that
cling to basement membrane |
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Filtration slits in visceral layer
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Filtration slits allow filtrate to pass into the
capsular space |
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Proximal convoluted tubule (PCT) made of
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• Cuboidal cells with dense microvilli and large
mitochondria |
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• Functions in reabsorption and secretion
• Confined to the cortex |
PCT
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Renal Tubule
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• Loop of Henle with descending and ascending
limbs |
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Thin segment of loop of Henle, usually in descending limb, Freely permeable to water, is made up of:
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• Simple squamous epithelium
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Thick segment of ascending limb of loop of henle is made up of:
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• Cuboidal to columnar cells
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DCT function:
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• Function more in secretion than reabsorption
• Confined to the cortex |
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Distal Convoluted Tubule cell make up:
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Cuboidal cells with very few microvilli
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Collecting Ducts (function)
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• Receive filtrate from many nephrons
• Fuse together to deliver urine through papillae into minor calyces |
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Collecting Ducts (make up)
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• Cell types
• Intercalated cells • Cuboidal cells with microvilli |
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INTERCALATED CELLS IN collecting ducts
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• Function in maintaining the acid-base balance of the body
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GLOMERURAL BLOOD PRESSURE IS HIGH BECAUSE
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• Afferent arterioles are smaller in diameter
than efferent arterioles • Arterioles are high-resistance vessels |
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Peritubular capillaries arise from
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• Arise from efferent arterioles
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Peritubular capillaries empty into:
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• Empty into venules
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Peritubular capillaries are
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• Low-pressure, porous capillaries adapted for
absorption |
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peritubular capillaries
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• Cling to adjacent renal tubules in cortex
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Nephron Capillary Beds
3. Vasa recta |
• Long vessels parallel to long loops of Henle
• Arise from efferent arterioles of juxtamedullary nephrons |
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Nephron Capillary Beds
3. Vasa recta |
• Function information of concentrated urine
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Juxtaglomerular Apparatus (JGA) how many?
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• One per nephron
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Juxtaglomerular Apparatus (JGA) function:
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• Important in regulation of filtrate formation and
blood pressure |
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Juxtaglomerular Apparatus (JGA) location:
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• Distal portion of the ascending limb of the loop
of Henle |
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Juxtaglomerular Apparatus (JGA) type of arteriole:
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• AFFERENT (sometimes efferent) arteriole
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Juxtaglomerular Apparatus (JGA) cells:
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• Granular cells (juxtaglomerular, or JG cells)
• Enlarged, smooth muscle cells of arteriole |
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Juxtaglomerular Apparatus (JGA) act as:
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• Act as mechanoreceptors that sense blood
pressure |
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Juxtaglomerular Apparatus (JGA) contain:
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• Secretory granules contain renin
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Filtration Membrane
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• Porous membrane between the blood and the
capsular space |
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Filtration membrane consists of:
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• Consists of
1. Fenestrated endothelium of the glomerular capillaries 2. Visceral membrane of the glomerular capsule (podocytes with foot processes and filtration slits) 3. Gel-like basement membrane (fused basal laminae of the two other layers) |
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Glomerular capillary
covered by |
podocytecontaining
visceral layer of glomerular capsule |
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Filtration Membrane
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• Negatively charged basement membrane
repels large anions such as plasma proteins • Slit diaphragms also help to repel macromolecules |
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Filtration Membrane
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• Allows passage of water and solutes smaller
than most plasma proteins • Fenestrations prevent filtration of blood cells |
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hyperventilate
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reduce CO2
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reduce CO2 =
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bring reaction toward reduction
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acidosis
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causes hyperventilation
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hyperventilation
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blows off CO2
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holding breath, pulmonary restriction =
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buildup CO2, reaction
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RENAL ARTERY-
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caries blood from aorta to kidneys
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renal arteries are BEHIND the-
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renal veins
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renal artery to RIGHT kidney is -
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LONGER than the renal artery to the left kidney
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renal vein empties into the -
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inferior vena cava
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left kidney is higher than-
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the right kidney because the liver crowds the right kidney
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renaltosis is-
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decent or drop of kidneys due to loss of fat pad
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____ causes resistance to drainage of urine
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renaltosis
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kidney can perform-
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autoregulation
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kidney surrounded by -
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outer layer that does not stretch
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renal cortex-
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nephrons are there
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afferent arteriole-
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feeds glomerulus
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renal cortex-
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outer side
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renal columns =
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projections of the cortex INTO THE MEDULLA
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apex of PYRAMID
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papilla
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nephron =
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functional unit
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RENAL pyramid + its ancillary structures=
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renal lobe
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renal artery enters and becomes
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segmental artery
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interloba becomes
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arctuate
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arctuate becomes
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cortical radiate
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a portal system is
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fed and drained by an arteriole
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portal system connects 2 different
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capillary beds
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glomerulus leads to
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efferent and then peritubular capillaries
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peritubular capillaries
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low pressure
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glomerulus
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high pressure
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on the way out
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no segmental veins
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on way out interlobars flow into
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renal veins
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The afferent arteriole has a wider diameter
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than the efferent arteriole.
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membrane does not allow
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proteins to pass, but does allow amino acids to pass
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no proteins in the
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urine ever because proteins cannot get past the filtration membrane
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filtration membrane is selective on size and on
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charge (electrical), and size of particles
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simple osmosis.
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only water travel through cells no solvent drag at all
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transcellular water flow-
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water returns to us by travelling between the cells
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paracellular water flow-
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water returns to us by travelling between the cells
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solvent drag-
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water when returning to body drags in some solvent materials
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basal membrane
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large numbers of sodium atpase pumps, which remove sodium and bring in potassium
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potassium is the primary cation of the
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intracellular fluid
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sodium is the primary cation of the:
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extracellular fluid
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basolateral membrane of cell
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inward facing surface of epithelial cell, surface facing away from lumen, responsible for waste removal and dumping into lumen of renal tubule
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pumping Na into interstitial fluid makes it-
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hypertonic
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sodium =
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water attractant
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60-65% of water reabsorbed at:
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PCT
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SECONDARY ACTIVE TRANSPORT
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Na out makes room for more... other things brought in too...no ATP used directly
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symport
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both in
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antiport
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one in one out
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proximal tubular mechanism -
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to secrete H+
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convoluted tubule has:
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intercalated cells
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visceral layer of glomerular capsule:
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in order:
fenestrated endothelium of the glomerulus, basement layer, podocyte |
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Hydrogen ion secretion in the collecting tubule is the process primarily responsible for acidification of the urine:
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particularly during states of acidosis.
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Proximal reabsorption of bicarbonate can be affected by many factors, in particular:
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potassium balance, volume status and renin/angiotensin levels.
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proximal convoluted tubule has:
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microvilli and below that mitochondria
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Na
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most abundant cation in filtrate
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