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101 Cards in this Set

  • Front
  • Back
Renal cortex
A granular superficial region
• Renal medulla
• The cone-shaped medullary (renal) pyramids
separated by renal columns
• Lobe
• A medullary pyramid and its surrounding
cortical tissue
• Major calyces
• The branching channels of the renal pelvis that
• Collect urine from minor calyces
• Empty urine into the pelvis
kidneys lateral surface
convex lateral surface
renal hilum leads to
renal sinus
concave
medial
surface of kidneys
renal pelvis
funnel shaped tube within renal sinus
papila
the tip of pyramid, releases urine into calyx
2 main parts of nephron
Two main parts
1. Glomerulus: a tuft of capillaries
2. Renal tubule: begins as cup-shaped
glomerular (Bowman’s) capsule surrounding
the glomerulus
renal corpuscle =
glomerulus and its capsule
2 layers of renal tubule
-Parietal layer: simple squamous epithelium
• Visceral layer: branching epithelial podocytes
Parietal layer:
simple squamous epithelium
• Visceral layer
branching epithelial podocytes
podocytes
Extensions terminate in foot processes that
cling to basement membrane
Filtration slits in visceral layer
Filtration slits allow filtrate to pass into the
capsular space
Proximal convoluted tubule (PCT) made of
• Cuboidal cells with dense microvilli and large
mitochondria
• Functions in reabsorption and secretion
• Confined to the cortex
PCT
Renal Tubule
• Loop of Henle with descending and ascending
limbs
Thin segment of loop of Henle, usually in descending limb, Freely permeable to water, is made up of:
• Simple squamous epithelium
Thick segment of ascending limb of loop of henle is made up of:
• Cuboidal to columnar cells
DCT function:
• Function more in secretion than reabsorption
• Confined to the cortex
Distal Convoluted Tubule cell make up:
Cuboidal cells with very few microvilli
Collecting Ducts (function)
• Receive filtrate from many nephrons
• Fuse together to deliver urine through papillae
into minor calyces
Collecting Ducts (make up)
• Cell types
• Intercalated cells
• Cuboidal cells with microvilli
INTERCALATED CELLS IN collecting ducts
• Function in maintaining the acid-base balance of the body
GLOMERURAL BLOOD PRESSURE IS HIGH BECAUSE
• Afferent arterioles are smaller in diameter
than efferent arterioles
• Arterioles are high-resistance vessels
Peritubular capillaries arise from
• Arise from efferent arterioles
Peritubular capillaries empty into:
• Empty into venules
Peritubular capillaries are
• Low-pressure, porous capillaries adapted for
absorption
peritubular capillaries
• Cling to adjacent renal tubules in cortex
Nephron Capillary Beds
3. Vasa recta
• Long vessels parallel to long loops of Henle
• Arise from efferent arterioles of
juxtamedullary nephrons
Nephron Capillary Beds
3. Vasa recta
• Function information of concentrated urine
Juxtaglomerular Apparatus (JGA) how many?
• One per nephron
Juxtaglomerular Apparatus (JGA) function:
• Important in regulation of filtrate formation and
blood pressure
Juxtaglomerular Apparatus (JGA) location:
• Distal portion of the ascending limb of the loop
of Henle
Juxtaglomerular Apparatus (JGA) type of arteriole:
• AFFERENT (sometimes efferent) arteriole
Juxtaglomerular Apparatus (JGA) cells:
• Granular cells (juxtaglomerular, or JG cells)
• Enlarged, smooth muscle cells of arteriole
Juxtaglomerular Apparatus (JGA) act as:
• Act as mechanoreceptors that sense blood
pressure
Juxtaglomerular Apparatus (JGA) contain:
• Secretory granules contain renin
Filtration Membrane
• Porous membrane between the blood and the
capsular space
Filtration membrane consists of:
• Consists of
1. Fenestrated endothelium of the glomerular capillaries
2. Visceral membrane of the glomerular capsule
(podocytes with foot processes and filtration slits)
3. Gel-like basement membrane (fused basal laminae of
the two other layers)
Glomerular capillary
covered by
podocytecontaining
visceral
layer of glomerular
capsule
Filtration Membrane
• Negatively charged basement membrane
repels large anions such as plasma proteins
• Slit diaphragms also help to repel macromolecules
Filtration Membrane
• Allows passage of water and solutes smaller
than most plasma proteins
• Fenestrations prevent filtration of blood cells
hyperventilate
reduce CO2
reduce CO2 =
bring reaction toward reduction
acidosis
causes hyperventilation
hyperventilation
blows off CO2
holding breath, pulmonary restriction =
buildup CO2, reaction
RENAL ARTERY-
caries blood from aorta to kidneys
renal arteries are BEHIND the-
renal veins
renal artery to RIGHT kidney is -
LONGER than the renal artery to the left kidney
renal vein empties into the -
inferior vena cava
left kidney is higher than-
the right kidney because the liver crowds the right kidney
renaltosis is-
decent or drop of kidneys due to loss of fat pad
____ causes resistance to drainage of urine
renaltosis
kidney can perform-
autoregulation
kidney surrounded by -
outer layer that does not stretch
renal cortex-
nephrons are there
afferent arteriole-
feeds glomerulus
renal cortex-
outer side
renal columns =
projections of the cortex INTO THE MEDULLA
apex of PYRAMID
papilla
nephron =
functional unit
RENAL pyramid + its ancillary structures=
renal lobe
renal artery enters and becomes
segmental artery
interloba becomes
arctuate
arctuate becomes
cortical radiate
a portal system is
fed and drained by an arteriole
portal system connects 2 different
capillary beds
glomerulus leads to
efferent and then peritubular capillaries
peritubular capillaries
low pressure
glomerulus
high pressure
on the way out
no segmental veins
on way out interlobars flow into
renal veins
The afferent arteriole has a wider diameter
than the efferent arteriole.
membrane does not allow
proteins to pass, but does allow amino acids to pass
no proteins in the
urine ever because proteins cannot get past the filtration membrane
filtration membrane is selective on size and on
charge (electrical), and size of particles
simple osmosis.
only water travel through cells no solvent drag at all
transcellular water flow-
water returns to us by travelling between the cells
paracellular water flow-
water returns to us by travelling between the cells
solvent drag-
water when returning to body drags in some solvent materials
basal membrane
large numbers of sodium atpase pumps, which remove sodium and bring in potassium
potassium is the primary cation of the
intracellular fluid
sodium is the primary cation of the:
extracellular fluid
basolateral membrane of cell
inward facing surface of epithelial cell, surface facing away from lumen, responsible for waste removal and dumping into lumen of renal tubule
pumping Na into interstitial fluid makes it-
hypertonic
sodium =
water attractant
60-65% of water reabsorbed at:
PCT
SECONDARY ACTIVE TRANSPORT
Na out makes room for more... other things brought in too...no ATP used directly
symport
both in
antiport
one in one out
proximal tubular mechanism -
to secrete H+
convoluted tubule has:
intercalated cells
visceral layer of glomerular capsule:
in order:

fenestrated endothelium of the glomerulus, basement layer, podocyte
Hydrogen ion secretion in the collecting tubule is the process primarily responsible for acidification of the urine:
particularly during states of acidosis.
Proximal reabsorption of bicarbonate can be affected by many factors, in particular:
potassium balance, volume status and renin/angiotensin levels.
proximal convoluted tubule has:
microvilli and below that mitochondria
Na
most abundant cation in filtrate