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42 Cards in this Set
- Front
- Back
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what is the ratio of men to women with mycosis fungoides
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2:1
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what is the etiology of mycosis fungoides
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unknown
possibly genetics and viral |
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blacks are ____ as like to be affected than whites
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twice
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the incidence of mycosis fungoides _____ with age
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rises sharply
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what are the 3 phases of mycosis fungoides
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path or premycotic phase
infiltrated plaques or mycotic phase tumor or fungoid phase |
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what is the median survival after diagnosis
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5 years
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what are the sites of mycosis fungoides in decreasing order
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lymph nodes
spleen liver lungs bone marrow |
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what kind of biopsy is performed for MF
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several punch biopsies
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what are the 3 staging systems for MF
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stanford staging system
mycosis fungoides cooperative group TNM |
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what are the 3 prognostic factors for MF
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age
stage lab studies |
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what cell is involved with MF
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T cells (Sezary's)
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what is the survival of those with visceral involvement MF
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< 1 year
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what is the 3 year survival rate for those without nodal enlargement
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85%
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what is the 3 year survival rate for those with nodes in one region
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68%
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what is the 3 year survival rate for those with nodes in more than one region
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60%
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what may cure early stages of MF?
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intensive therapy to skin
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what is TSEB
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total skin electron beam therapy
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what are the 5 ways of managing MF
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TSEB
topically applied mechlorethamine photochemotherapy UVB phototherapy bone marrow transplant |
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what is the most effective treatment for MF
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ionizing radiation
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what energies are typically used for MF
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10-15MeV
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what is the dose fractionation and total dose typically used for MF
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20-30 Gy in 10-15 treatments
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what is the most common RT technique
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TSEB
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what is the energy for TSEB
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3-6MeV
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what are the typical fields for TSEB
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3 ant and 3 post stationary fields
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what is the fraction and total dose of TSEB
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1.5-2Gy each 2 day cycle
30-40Gy with a few weeks of a break at 18-20Gy |
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what type of shielding should be used with TSEB
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internal or external eye shields
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what are some short term side effects of MF
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erythema
desquamation swelling of hands edema alopecia |
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what are some long term side effects of MF
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wrinkling
xerosis uneven pigmentation permanent alopecia skin fragility |
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how does Kaposi's sarcoma present itself
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as one or more lesions on the hands, arms, legs, ankles, or soles of feet
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what are 3 AIDS defining conditions when they occur with HIV infections
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Kaposi's sarcoma
NHL carcinoma of cervix |
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what is the most common malignancy in aids patients
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Kaposi's sarcoma
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what kind of herpes is KS
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human herpes virus 8
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what cell does KS originate from
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mesenchymal
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histological diagnosis requires both...
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spindle cell and vascular elements
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what are the 3 treatment options for KS
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systemic approach
interferon chemo |
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KS local therapy for palliation of ____ _____ _____ can be used
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pain
bleeding edema |
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lesions of KS may take how long to respond
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3-4 months
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what is the fractionation and total dose of KS
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3000cGy in 10 fractions
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what % of KS completely respond
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70%
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for painful or swollen KS, should wrap in bolus and deliver a single dose of
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800cGy
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what is hidradenocarcinoma
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carcinoma of the sweat glands
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where is hidradenocarcinoma located
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on the face or scalp
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