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4 Cards in this Set
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Melatonin background |
Hormone that is produced in the pineal gland. Plays a vital role in the human sleep and wake cycle otherwise known as the circadian rhythm.
You can find in the grocery store as an over the counter sleeping aid. |
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Melatonin |
Synthesized and metabolized in the skin Regulates cutaneous pigmentation and barrier functions Is oncostatic (halts the spread of cancer) Photo protective Anti oxidant |
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Synthesis of melatonin |
Traditionally melatonin is synthesized via this mechanism. |
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Via methods of liquid chromatography and mass spectrometry |
Researchers were able to identify melatonin and its metabolites in hamster and human skin as well normal keratinocytes, melanocytes, and melanoma cells Concentrations dependent on race, gender, and age of the donors [36]. Interestingly, the highest melatonin concentration was found in the epidermis from African-American
Researchers documented that that melatonin is both produced endogenously and also posses all the biochemical elements required for synthesis of melatonin via the indolic pathway
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