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6 Cards in this Set
- Front
- Back
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What are the polyenes?
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Amphotericin B
Nystatin |
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Name the Allylamines
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Trbinafine, naftifine, terinafine
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What is the mechanism of action of the polyenes antifungals?
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Polyenes (amphtericin B, nystatin)
Bind irreversibly wiht ergosterol (prinicpal sterol in the fungal cell membrane) This causle altered membrane permealbility resulting in leakage and cell death. |
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What is the use, dose, side effects, and drug reactions for amphotericin B
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Amphotericine B:
Use: IV for potentially life threatening dee mycotic/systemic fengemia Dose: 0.25/kg/day infused slowly over 6 hours (monitor BUN/CR). With increase of Cr to > 3.0 switch to lipophilic Amphtericin B (Amphotec) Side effects: GI distress, fever, chills, headaches, hypotension, hypokalemia, hypomagnesemia, anemia, thrombophlebitis, liver failure, renal failure Drug reactions: aminoglcosides & cyclosprin: synergistic nephrotoxicity Corticosteroids & K+ depleting diuretic: may potentiate hypokalemia, hypomagnesemia |
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What is the mechanism of action of azoles?
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inhibit gowth of fungi by interfering iwth cell membrane ergosterol bioshythesis
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Who should avoid taking ketoconazole
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Patients with sulfite sensitivity should avoid taking ketoconazole (nizoral).
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