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6 Cards in this Set

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What are the polyenes?
Amphotericin B
Nystatin
Name the Allylamines
Trbinafine, naftifine, terinafine
What is the mechanism of action of the polyenes antifungals?
Polyenes (amphtericin B, nystatin)

Bind irreversibly wiht ergosterol (prinicpal sterol in the fungal cell membrane) This causle altered membrane permealbility resulting in leakage and cell death.
What is the use, dose, side effects, and drug reactions for amphotericin B
Amphotericine B:

Use: IV for potentially life threatening dee mycotic/systemic fengemia

Dose: 0.25/kg/day infused slowly over 6 hours (monitor BUN/CR). With increase of Cr to > 3.0 switch to lipophilic Amphtericin B (Amphotec)

Side effects: GI distress, fever, chills, headaches, hypotension, hypokalemia, hypomagnesemia, anemia, thrombophlebitis, liver failure, renal failure

Drug reactions:
aminoglcosides & cyclosprin: synergistic nephrotoxicity
Corticosteroids & K+ depleting diuretic: may potentiate hypokalemia, hypomagnesemia
What is the mechanism of action of azoles?
inhibit gowth of fungi by interfering iwth cell membrane ergosterol bioshythesis
Who should avoid taking ketoconazole
Patients with sulfite sensitivity should avoid taking ketoconazole (nizoral).