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11 Cards in this Set
- Front
- Back
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What is the risk of neuraxial anesthesia on patients on LMW heparin?
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SAB/Epidural hematoma
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What is the MOA of LMW heparin?
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Inhibition of Factor X by binding to antithrombin III and accellerating its activity
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Does LMW heparin prolong PTT?
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No
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Is LMW heparin reversed w/ protamine?
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Incompletely
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What is the pathology of sickle cell anemia?
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Modification of Beta chain of Hb -> polymerization and sickling w/ hypoxia, hypothermia, acidosis, dehydration
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What is the lifespan of a sickle cell RBC?
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12-18 days (nml 120 days)
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What is tx for sickle cell crisis?
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1oo% FiO2, Normalize CO, B/P, fluids (fix dehydration)
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Describe sickle cell trait in heterozygous individuals
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30% abnormal Hb, sickles at 20 mmHg
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Describe sickle cell trait in homozygous individuals
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90% abnormal Hb, sickles at 40 mmHg (appox equal to normal Pulmonary artery PaO2)
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What are the typical clinical manifestations of sickle cell anemia?
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Anemia (Hb=5-10) d/t hemolysis; Increased CO; Increased Bili (d/t hemolysis)
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What GI disease is associated w/ sickle cell?
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cholelithiasis d/t increased bili d/t hemolysis
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