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19 Cards in this Set
- Front
- Back
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Describe Catagory A in relation to pregnancy.
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Large number of women have taken with no proven increase in frequency of malformations or harmful defects
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Describe Catagory C in relation to pregnancy.
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Drugs which have caused/suspected of causeing harmfrul effects withOUT causing malformations. Effects may be reversible
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Examples of Catagory C
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Aspirin - can tak first half of preg but not second as it closes the Ductus Arteriosis
Anti-depressents increase breech babies |
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Describe Catagory B in relation to pregnancy.
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Drug without proof...
Taken by a small amount of women but have not yet shown an increase in the frequency of malformations or harmful effects |
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What are the subtypes of catagory B?
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B1: No evidence of damage to animal foetus
B2: Inadequate animal studies but so far no evidence of damage B3:Increased foetal damage in humans but significance uncertain |
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Describe Catagory D in relation to pregnancy.
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Drugs which have/are suspected of causing increased human foetal malformations or irreversible damage.
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Examples of Catagory D drugs
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Lithium (anti-depressent
Anti-epileptic drugs Vitamin A Chemo drugs |
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Describe Catagory X in relation to pregnancy.
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Drugs with a high risk of causing permanent damage to the foetus.
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Example of Catagory X
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Ribavirin for HepC
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What is the most critical time that drugs can cause malformation?
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Organogenesis - 18 to 55 days
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List some drugs that should not be taken in preg
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Sedatives
Ectasy (feotal death in high temp) Amphetamines (Sublingual OK) ICE - placental abruption COCAINE - placental abruption Laxative (SM contraction) Anti fungals Steroid creams (avoid 1st tri) Nasal sprays/decongestants |
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What is the function of hCG?
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maintains corpus luteum
may repel immune cells peaks at start of preg |
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Where does Relaxin come from? What is the function of Relaxin?
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Comes from the corups luteum and placenta.
Vasodillation leading to an increase in the RAA system Relase of Vasopressin Block Oxytoxin THus increase water retention and blood volume |
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What is the function of Progesterone?
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Convert uterine endometrium to secretory stage for implantation
Decreased immune response Decrease uterine contractility Increases water sorption and constipation |
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What is the function of Somatonammotropin? What is the significane?
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Increase insulin resistance - Gestational diabetes. Can lead to excessive growth of newborn.
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What hormone increases metabollic rate?
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Thyroxine
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How is pre-eclampsia discovered?
What is used to treat it? |
Proteuria (eg albumin)
Hypertension Oedema Vasodilator - Hydralazine |
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What is the significance of Bacterutia in pregnancy?
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5% of women have it asymptomatically
40% of this can lead to acute cytitis in pregnancy Relative risk of pre-term preg DOUBLES |
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What can be used to treat malaria safely in pregnancy?
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Cholorquine
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